Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2 FamilyLegumain-like8049300 4006439 SCOP2 (2022-06-29)
ASCOP2 SuperfamilyCaspase-like8104074 3001096 SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AKOG1348e4nomA1 A: alpha arraysX: Legumain prodomain (From Topology)H: Legumain prodomain (From Topology)T: Legumain prodomainF: KOG1348ECOD (1.6)
APeptidase_C13e4nomA2 A: a/b three-layered sandwichesX: Caspase-like (From Topology)H: Caspase-like (From Topology)T: Caspase-likeF: Peptidase_C13ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.40.50.1460 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold CATH (4.3.0)
A1.10.132.130 Mainly Alpha Orthogonal Bundle Topoisomerase I Chain A, domain 4CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF01650Peptidase C13 family (Peptidase_C13)Peptidase C13 family- Family
PF20985Legumain, prodomain (Legum_prodom)Legumain, prodomainThis domain is found in the proenzyme form of Vacuolar-processing enzyme (VPE), known as legumain. VPE is an asparagine-specific endopeptidase that plays important roles in many physiological processes, including the maturation of toll-like receptors ...This domain is found in the proenzyme form of Vacuolar-processing enzyme (VPE), known as legumain. VPE is an asparagine-specific endopeptidase that plays important roles in many physiological processes, including the maturation of toll-like receptors 3/7/9. The mature active form of VPE is generated by autoproteolytic maturation at acidic pH. In the three-dimensional structure of the proenzyme, this prodomain is located on top of the protease domain, blocking access to the active site. It shows an entirely alpha-helical fold, with an activation peptide and a region that assemblies into a death domain-like fold at its C-terminal end [1-5].
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
Legumain