4NL8
PriA Helicase Bound to SSB C-terminal Tail Peptide
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
B [auth A] | PF18074 | e4nl8A3 | A: a+b two layers | X: Alpha-beta plaits | H: Ribosomal protein S10 (From Topology) | T: Ribosomal protein S10 | F: PF18074 | ECOD (1.6) |
B [auth A] | PF17764 | e4nl8A1 | A: a+b complex topology | X: Primosome assembly protein PriA 3' DNA-binding domain (From Topology) | H: Primosome assembly protein PriA 3' DNA-binding domain (From Topology) | T: Primosome assembly protein PriA 3' DNA-binding domain | F: PF17764 | ECOD (1.6) |
B [auth A] | PF00270 | e4nl8A4 | A: a/b three-layered sandwiches | X: P-loop domains-like | H: P-loop domains-related | T: P-loop containing nucleoside triphosphate hydrolases | F: PF00270 | ECOD (1.6) |
B [auth A] | PF18319 | e4nl8A2 | A: a/b three-layered sandwiches | X: P-loop domains-like | H: P-loop domains-related | T: P-loop containing nucleoside triphosphate hydrolases | F: PF18319 | ECOD (1.6) |
D [auth B] | PF18074 | e4nl8B4 | A: a+b two layers | X: Alpha-beta plaits | H: Ribosomal protein S10 (From Topology) | T: Ribosomal protein S10 | F: PF18074 | ECOD (1.6) |
D [auth B] | PF17764 | e4nl8B3 | A: a+b complex topology | X: Primosome assembly protein PriA 3' DNA-binding domain (From Topology) | H: Primosome assembly protein PriA 3' DNA-binding domain (From Topology) | T: Primosome assembly protein PriA 3' DNA-binding domain | F: PF17764 | ECOD (1.6) |
D [auth B] | PF00270 | e4nl8B1 | A: a/b three-layered sandwiches | X: P-loop domains-like | H: P-loop domains-related | T: P-loop containing nucleoside triphosphate hydrolases | F: PF00270 | ECOD (1.6) |
D [auth B] | PF00271,PF18319 | e4nl8B2 | A: a/b three-layered sandwiches | X: P-loop domains-like | H: P-loop domains-related | T: P-loop containing nucleoside triphosphate hydrolases | F: PF00271,PF18319 | ECOD (1.6) |
F [auth E] | PF18074 | e4nl8E4 | A: a+b two layers | X: Alpha-beta plaits | H: Ribosomal protein S10 (From Topology) | T: Ribosomal protein S10 | F: PF18074 | ECOD (1.6) |
F [auth E] | PF17764 | e4nl8E3 | A: a+b complex topology | X: Primosome assembly protein PriA 3' DNA-binding domain (From Topology) | H: Primosome assembly protein PriA 3' DNA-binding domain (From Topology) | T: Primosome assembly protein PriA 3' DNA-binding domain | F: PF17764 | ECOD (1.6) |
F [auth E] | PF00270 | e4nl8E1 | A: a/b three-layered sandwiches | X: P-loop domains-like | H: P-loop domains-related | T: P-loop containing nucleoside triphosphate hydrolases | F: PF00270 | ECOD (1.6) |
F [auth E] | PF00271 | e4nl8E2 | A: a/b three-layered sandwiches | X: P-loop domains-like | H: P-loop domains-related | T: P-loop containing nucleoside triphosphate hydrolases | F: PF00271 | ECOD (1.6) |
F [auth E] | PF18319 | e4nl8E5 | A: few secondary structure elements | X: Rubredoxin-like | H: Rubredoxin-related | T: Rubredoxin-related | F: PF18319 | ECOD (1.6) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
B [auth A], D [auth B], F [auth E] | PF18074 | Primosomal protein N C-terminal domain (PriA_C) | Primosomal protein N C-terminal domain | This is the C-terminal domain found in PriA DNA helicase, a multifunctional enzyme that mediates the process of restarting prematurely terminated DNA replication reactions in bacteria. The C-terminal domain (CTD) bears similarity to the S10 subunit w ... | Domain |
B [auth A], D [auth B], F [auth E] | PF00270 | DEAD/DEAH box helicase (DEAD) | DEAD/DEAH box helicase | Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome ... | Domain |
B [auth A], D [auth B], F [auth E] | PF17764 | 3'DNA-binding domain (3'BD) (PriA_3primeBD) | 3'DNA-binding domain (3'BD) | This domain represents the N-terminal DNA-binding domain found in the PriA protein. The 3'BD, which has been shown to bind the 3' end of the leading-strand arm of replication fork structures. | Domain |
B [auth A], D [auth B], F [auth E] | PF18319 | PriA DNA helicase Cys-rich region (CRR) domain (PriA_CRR) | PriA DNA helicase Cys-rich region (CRR) domain | This is a cys-rich region (CRR) domain found in PriA DNA helicases. In bacteria, the replication restart process is orchestrated by the PriA DNA helicase, which identifies replication forks via structure-specific DNA binding and interactions with for ... | Domain |