4MZZ

Crystal structure of Bovine 3 Glu-Osteocalcin.

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d4mzzb_	Small proteins	GLA-domain	GLA-domain	GLA-domain	automated matches	bovine,cow,domestic cattle,domestic cow (Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
A	d4mzza_	Small proteins	GLA-domain	GLA-domain	GLA-domain	automated matches	bovine,cow,domestic cattle,domestic cow (Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	GLA-domain	8039632	3001028	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	GLA-domain	8039632	3001028	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	F_UNCLASSIFIED	e4mzzB1	A: few secondary structure elements	X: GLA-domain (From Topology)	H: GLA-domain (From Topology)	T: GLA-domain	F: F_UNCLASSIFIED	ECOD (1.6)
A	F_UNCLASSIFIED	e4mzzA1	A: few secondary structure elements	X: GLA-domain (From Topology)	H: GLA-domain (From Topology)	T: GLA-domain	F: F_UNCLASSIFIED	ECOD (1.6)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Osteocalcin	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding structural molecule activity structural constituent of bone hormone activity protein binding molecular function activator activity signaling receptor binding molecular function regulator activity signaling receptor regulator activity cation binding ion binding binding calcium ion binding metal ion binding small molecule binding structural molecule activity structural constituent of bone hormone activity protein binding molecular function activator activity signaling receptor binding molecular function regulator activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity hydroxyapatite binding	developmental process multicellular organism development multicellular organismal process head development central nervous system development anatomical structure development animal organ development brain development nervous system development system development cellular developmental process ossification cell differentiation cellular process developmental process multicellular organism development multicellular organismal process head development central nervous system development anatomical structure development animal organ development brain development nervous system development system development cellular developmental process ossification cell differentiation cellular process osteoblast differentiation skeletal system development bone development regulation of multicellular organismal development regulation of biological process negative regulation of bone development regulation of developmental process negative regulation of developmental process biological regulation negative regulation of biological process regulation of bone development regulation of multicellular organismal process negative regulation of multicellular organismal process system process nervous system process cognition bone mineralization regulation of biomineral tissue development regulation of bone mineralization tissue development biomineral tissue development regulation of ossification cell population proliferation type B pancreatic cell proliferation epithelial cell proliferation behavior learning or memory positive regulation of cell communication regulation of localization cellular localization regulation of cellular process transport modulation of chemical synaptic transmission signaling positive regulation of neurotransmitter secretion positive regulation of biological process positive regulation of secretion by cell cell communication localization synaptic signaling regulation of secretion by cell secretion by cell positive regulation of secretion signal release establishment of localization in cell positive regulation of cellular process trans-synaptic signaling regulation of signaling positive regulation of neurotransmitter transport neurotransmitter secretion regulation of transport secretion regulation of neurotransmitter transport export from cell cell-cell signaling positive regulation of synaptic transmission neurotransmitter transport establishment of localization regulation of secretion chemical synaptic transmission signal release from synapse regulation of trans-synaptic signaling positive regulation of transport regulation of neurotransmitter secretion anterograde trans-synaptic signaling regulation of cell communication positive regulation of signaling cellular response to stimulus cellular response to nitrogen compound response to organic substance response to stimulus response to endogenous stimulus response to organonitrogen compound response to peptide hormone response to oxygen-containing compound cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound cellular response to endogenous stimulus cellular response to chemical stimulus cellular response to organonitrogen compound response to hormone response to chemical response to insulin cellular response to organic substance cellular response to insulin stimulus cellular response to hormone stimulus regulation of cellular response to insulin stimulus regulation of response to stimulus response to nutrient levels response to ketone response to nutrient response to vitamin K response to vitamin regulation of steroid biosynthetic process cellular biosynthetic process organic hydroxy compound metabolic process steroid metabolic process regulation of lipid metabolic process lipid biosynthetic process regulation of primary metabolic process cellular ketone metabolic process organic substance metabolic process regulation of small molecule metabolic process regulation of testosterone biosynthetic process organic substance biosynthetic process small molecule metabolic process steroid biosynthetic process regulation of biosynthetic process regulation of cellular ketone metabolic process small molecule biosynthetic process olefinic compound biosynthetic process regulation of ketone biosynthetic process cellular metabolic process regulation of steroid metabolic process regulation of cellular metabolic process primary metabolic process regulation of cellular biosynthetic process testosterone biosynthetic process organic cyclic compound metabolic process biosynthetic process organic hydroxy compound biosynthetic process organic cyclic compound biosynthetic process metabolic process olefinic compound metabolic process regulation of lipid biosynthetic process regulation of metabolic process ketone biosynthetic process lipid metabolic process chemical homeostasis homeostatic process glucose homeostasis carbohydrate homeostasis	intracellular anatomical structure cytoplasm cellular anatomical entity extracellular region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR000294	Gamma-carboxyglutamic acid-rich (GLA) domain	Domain
A, B	IPR039176	Osteocalcin	Family
A, B	IPR035972	Gamma-carboxyglutamic acid-rich (GLA) domain superfamily	Homologous Superfamily
A, B	IPR002384	Osteocalcin/matrix Gla protein	Family

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B	OPM				GLA-domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.