4MZO

Mouse cathepsin s with covalent ligand (3S,4S)-N-[(2E)-2-IMINOETHYL]-4-(MORPHOLIN-4-YLCARBONYL)-1-(PHENYLSULFONYL)PYRROLIDINE-3-CARBOXAMIDE

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4mzoa_	Alpha and beta proteins (a+b)	Cysteine proteinases	Cysteine proteinases	Papain-like	automated matches	mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
B	d4mzob_	Alpha and beta proteins (a+b)	Cysteine proteinases	Cysteine proteinases	Papain-like	automated matches	mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
C	d4mzoc_	Alpha and beta proteins (a+b)	Cysteine proteinases	Cysteine proteinases	Papain-like	automated matches	mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
D	d4mzod_	Alpha and beta proteins (a+b)	Cysteine proteinases	Cysteine proteinases	Papain-like	automated matches	mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
E	d4mzoe_	Alpha and beta proteins (a+b)	Cysteine proteinases	Cysteine proteinases	Papain-like	automated matches	mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
F	d4mzof_	Alpha and beta proteins (a+b)	Cysteine proteinases	Cysteine proteinases	Papain-like	automated matches	mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
G	d4mzog_	Alpha and beta proteins (a+b)	Cysteine proteinases	Cysteine proteinases	Papain-like	automated matches	mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
H	d4mzoh_	Alpha and beta proteins (a+b)	Cysteine proteinases	Cysteine proteinases	Papain-like	automated matches	mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Cysteine proteinases	8066295	3001808	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Cysteine proteinases	8066295	3001808	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Cysteine proteinases	8066295	3001808	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Cysteine proteinases	8066295	3001808	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Cysteine proteinases	8066295	3001808	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Cysteine proteinases	8066295	3001808	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Cysteine proteinases	8066295	3001808	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Cysteine proteinases	8066295	3001808	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00112	e4mzoA1	A: a+b complex topology	X: Cysteine proteinases-like	H: Cysteine proteinases (From Topology)	T: Cysteine proteinases	F: PF00112	ECOD (1.6)
B	PF00112	e4mzoB1	A: a+b complex topology	X: Cysteine proteinases-like	H: Cysteine proteinases (From Topology)	T: Cysteine proteinases	F: PF00112	ECOD (1.6)
C	PF00112	e4mzoC1	A: a+b complex topology	X: Cysteine proteinases-like	H: Cysteine proteinases (From Topology)	T: Cysteine proteinases	F: PF00112	ECOD (1.6)
D	PF00112	e4mzoD1	A: a+b complex topology	X: Cysteine proteinases-like	H: Cysteine proteinases (From Topology)	T: Cysteine proteinases	F: PF00112	ECOD (1.6)
E	PF00112	e4mzoE1	A: a+b complex topology	X: Cysteine proteinases-like	H: Cysteine proteinases (From Topology)	T: Cysteine proteinases	F: PF00112	ECOD (1.6)
F	PF00112	e4mzoF1	A: a+b complex topology	X: Cysteine proteinases-like	H: Cysteine proteinases (From Topology)	T: Cysteine proteinases	F: PF00112	ECOD (1.6)
G	PF00112	e4mzoG1	A: a+b complex topology	X: Cysteine proteinases-like	H: Cysteine proteinases (From Topology)	T: Cysteine proteinases	F: PF00112	ECOD (1.6)
H	PF00112	e4mzoH1	A: a+b complex topology	X: Cysteine proteinases-like	H: Cysteine proteinases (From Topology)	T: Cysteine proteinases	F: PF00112	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.90.70.10	Alpha Beta	Alpha-Beta Complex	Cathepsin B	Chain A	CATH (4.3.0)
B	3.90.70.10	Alpha Beta	Alpha-Beta Complex	Cathepsin B	Chain A	CATH (4.3.0)
C	3.90.70.10	Alpha Beta	Alpha-Beta Complex	Cathepsin B	Chain A	CATH (4.3.0)
D	3.90.70.10	Alpha Beta	Alpha-Beta Complex	Cathepsin B	Chain A	CATH (4.3.0)
E	3.90.70.10	Alpha Beta	Alpha-Beta Complex	Cathepsin B	Chain A	CATH (4.3.0)
F	3.90.70.10	Alpha Beta	Alpha-Beta Complex	Cathepsin B	Chain A	CATH (4.3.0)
G	3.90.70.10	Alpha Beta	Alpha-Beta Complex	Cathepsin B	Chain A	CATH (4.3.0)
H	3.90.70.10	Alpha Beta	Alpha-Beta Complex	Cathepsin B	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H	PF00112	Papain family cysteine protease (Peptidase_C1)	Papain family cysteine protease	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H	Cathepsin S	peptidase activity catalytic activity, acting on a protein hydrolase activity catalytic activity cysteine-type peptidase activity cysteine-type endopeptidase activity endopeptidase activity collagen binding protein-containing complex binding binding extracellular matrix binding protein binding laminin binding enzyme regulator activity peptidase activity catalytic activity, acting on a protein hydrolase activity catalytic activity cysteine-type peptidase activity cysteine-type endopeptidase activity endopeptidase activity collagen binding protein-containing complex binding binding extracellular matrix binding protein binding laminin binding enzyme regulator activity enzyme activator activity peptidase regulator activity molecular function activator activity cysteine-type endopeptidase activator activity involved in apoptotic process molecular function regulator activity cysteine-type endopeptidase regulator activity involved in apoptotic process peptidase activator activity peptidase activator activity involved in apoptotic process fibronectin binding proteoglycan binding carbohydrate derivative binding	collagen catabolic process catabolic process metabolic process collagen metabolic process regulation of localization positive regulation of cation transmembrane transport regulation of cellular process transport monoatomic ion transmembrane transport positive regulation of biological process regulation of transmembrane transporter activity regulation of monoatomic ion transmembrane transport regulation of transporter activity monoatomic cation transmembrane transport collagen catabolic process catabolic process metabolic process collagen metabolic process regulation of localization positive regulation of cation transmembrane transport regulation of cellular process transport monoatomic ion transmembrane transport positive regulation of biological process regulation of transmembrane transporter activity regulation of monoatomic ion transmembrane transport regulation of transporter activity monoatomic cation transmembrane transport localization positive regulation of molecular function positive regulation of monoatomic ion transport positive regulation of transmembrane transport monoatomic ion transport positive regulation of monoatomic ion transmembrane transport monoatomic cation transport positive regulation of cellular process regulation of monoatomic ion transmembrane transporter activity regulation of biological process regulation of transport regulation of monoatomic ion transport biological regulation positive regulation of cation channel activity establishment of localization regulation of cation channel activity transmembrane transport regulation of molecular function regulation of transmembrane transport positive regulation of transport positive regulation of transporter activity positive regulation of ion transmembrane transporter activity cellular process regulation of monoatomic cation transmembrane transport cellular response to stimulus positive regulation of cell communication positive regulation of signal transduction response to stimulus signaling regulation of signal transduction regulation of programmed cell death positive regulation of apoptotic signaling pathway cell communication positive regulation of response to stimulus signal transduction regulation of signaling positive regulation of programmed cell death regulation of apoptotic process cell death positive regulation of apoptotic process apoptotic signaling pathway regulation of response to stimulus regulation of cell communication apoptotic process programmed cell death positive regulation of signaling regulation of apoptotic signaling pathway regulation of defense response regulation of response to external stimulus defense response response to external stimulus regulation of inflammatory response positive regulation of response to external stimulus positive regulation of inflammatory response regulation of response to stress response to stress positive regulation of defense response inflammatory response immune response immune system process organonitrogen compound catabolic process organonitrogen compound metabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis protein metabolic process macromolecule metabolic process organic substance catabolic process antigen processing and presentation of exogenous peptide antigen via MHC class II antigen processing and presentation antigen processing and presentation of peptide or polysaccharide antigen via MHC class II antigen processing and presentation of peptide antigen via MHC class II antigen processing and presentation of exogenous peptide antigen antigen processing and presentation of peptide antigen antigen processing and presentation of exogenous antigen cellular component organization cellular component disassembly extracellular matrix disassembly basement membrane disassembly extracellular matrix organization cellular component organization or biogenesis extracellular structure organization external encapsulating structure organization basement membrane organization cellular biosynthetic process cellular metabolic process gene expression macromolecule biosynthetic process protein maturation biosynthetic process organic substance biosynthetic process protein processing response to pH response to abiotic stimulus response to acidic pH multicellular organismal process multicellular organismal-level homeostasis homeostatic process tissue remodeling bone remodeling anatomical structure homeostasis tissue homeostasis bone resorption	membrane cellular anatomical entity cell surface membrane-bounded organelle intracellular anatomical structure intracellular vesicle phagocytic vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle organelle cytoplasm vesicle endocytic vesicle membrane cellular anatomical entity cell surface membrane-bounded organelle intracellular anatomical structure intracellular vesicle phagocytic vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle organelle cytoplasm vesicle endocytic vesicle early endosome endosome membrane-enclosed lumen endomembrane system intracellular organelle lumen organelle lumen endosome lumen early endosome lumen lytic vacuole vacuole lysosome late endosome extracellular region extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H	IPR025661	Cysteine peptidase, asparagine active site	Active Site
A, B, C, D, E A, B, C, D, E, F, G, H	IPR000169	Cysteine peptidase, cysteine active site	Active Site
A, B, C, D, E A, B, C, D, E, F, G, H	IPR038765	Papain-like cysteine peptidase superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR013128	Peptidase C1A	Family
A, B, C, D, E A, B, C, D, E, F, G, H	IPR000668	Peptidase C1A, papain C-terminal	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR013201	Cathepsin propeptide inhibitor domain (I29)	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR025660	Cysteine peptidase, histidine active site	Active Site
A, B, C, D, E A, B, C, D, E, F, G, H	IPR039417	Papain-like cysteine endopeptidase	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.