4MXW
Structure of heterotrimeric lymphotoxin LTa1b2 bound to lymphotoxin beta receptor LTbR and anti-LTa Fab
External Resource: Annotation
- Domain Annotation: SCOP2 Classification
- Domain Annotation: ECOD Classification
- Domain Annotation: CATH
- IMGT Antibody Annotation
- SAbDab Antibody Annotation
- Thera-SAbDab Antibody Annotation
- Protein Family Annotation
- Gene Ontology: Gene Product Annotation
- InterPro: Protein Family Classification
- Pharos: Disease Associations
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
B [auth X] | SCOP2B Superfamily | TNF-like | 8064727 | 3000061 | SCOP2B (2022-06-29) |
E [auth A] | SCOP2B Superfamily | TNF-like | 8064727 | 3000061 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
H [auth R] | F_UNCLASSIFIED | e4mxwR1 | A: few secondary structure elements | X: EGF-like | H: EGF-related | T: TNF receptor-like | F: F_UNCLASSIFIED | ECOD (1.6) |
H [auth R] | PF00020 | e4mxwR2 | A: few secondary structure elements | X: EGF-like | H: EGF-related | T: TNF receptor-like | F: PF00020 | ECOD (1.6) |
A [auth S] | F_UNCLASSIFIED | e4mxwS2 | A: few secondary structure elements | X: EGF-like | H: EGF-related | T: TNF receptor-like | F: F_UNCLASSIFIED | ECOD (1.6) |
A [auth S] | PF00020 | e4mxwS1 | A: few secondary structure elements | X: EGF-like | H: EGF-related | T: TNF receptor-like | F: PF00020 | ECOD (1.6) |
B [auth X] | PF00229 | e4mxwX1 | A: beta sandwiches | X: jelly-roll | H: TNF-like (From Topology) | T: TNF-like | F: PF00229 | ECOD (1.6) |
E [auth A] | PF00229 | e4mxwA1 | A: beta sandwiches | X: jelly-roll | H: TNF-like (From Topology) | T: TNF-like | F: PF00229 | ECOD (1.6) |
C [auth Y] | PF00229 | e4mxwY1 | A: beta sandwiches | X: jelly-roll | H: TNF-like (From Topology) | T: TNF-like | F: PF00229 | ECOD (1.6) |
G [auth D] | PF00229 | e4mxwD1 | A: beta sandwiches | X: jelly-roll | H: TNF-like (From Topology) | T: TNF-like | F: PF00229 | ECOD (1.6) |
D [auth Z] | PF00229 | e4mxwZ1 | A: beta sandwiches | X: jelly-roll | H: TNF-like (From Topology) | T: TNF-like | F: PF00229 | ECOD (1.6) |
F [auth B] | PF00229 | e4mxwB1 | A: beta sandwiches | X: jelly-roll | H: TNF-like (From Topology) | T: TNF-like | F: PF00229 | ECOD (1.6) |
J [auth H] | PF07654 | e4mxwH1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07654 | ECOD (1.6) |
J [auth H] | PF07686 | e4mxwH2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07686 | ECOD (1.6) |
I [auth W] | PF07654 | e4mxwW1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07654 | ECOD (1.6) |
I [auth W] | PF07686 | e4mxwW2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07686 | ECOD (1.6) |
L | PF07654 | e4mxwL1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07654 | ECOD (1.6) |
L | PF07686 | e4mxwL2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07686 | ECOD (1.6) |
K [auth V] | PF07654 | e4mxwV1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07654 | ECOD (1.6) |
K [auth V] | PF07686 | e4mxwV2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07686 | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
IMGT Antibody Annotation IMGT Database Homepage
Chain | Protein Name | Description | Organism Name | Gene Allele Name(s) | Domain Name(s) | Receptor Type | Receptor Description | Provenance Source |
---|---|---|---|---|---|---|---|---|
A [auth S], H [auth R] | TNFRSF3 (Tumor necrosis factor receptor superfamily member) | LTBR | Homo sapiens (human) | LTBR*01 | R-LIKE-DOMAIN TNFR-CYS | RPI | LTBR | IMGT (202417-0) |
I [auth W], J [auth H] | anti-Lymphotoxin alpha antibody | VH-CH1 | Homo sapiens (human) | IGHV3-74*01, IGHV3-74*02, IGHV3-74*03, IGHJ6*01, IGHJ6*02, IGHG1*01, IGHG1*02, IGHG1*04, IGHG1*05 | V-DOMAIN VH, C-DOMAIN CH1 | IG | FAB-GAMMA-1_KAPPA | IMGT (202417-0) |
K [auth V], L | anti-Lymphotoxin alpha antibody | L-KAPPA | Homo sapiens (human) | IGKV1-39*01, IGKV1D-39*01, IGKJ1*01, IGKC*01 | V-DOMAIN V-KAPPA, C-DOMAIN C-KAPPA | IG | FAB-GAMMA-1_KAPPA | IMGT (202417-0) |
SAbDab Antibody Annotation SAbDab Database Homepage
Chain | Chain Class | Chain Subclass | Chain Type | Antigen Name(s) | Provenance Source |
---|---|---|---|---|---|
I [auth W], J [auth H] | Heavy Chain | IGHV3 | - | lymphotoxin-alpha | SAbDab (2024-05-03) |
K [auth V], L | Light Chain | IGKV1 | Kappa | lymphotoxin-alpha | SAbDab (2024-05-03) |
Thera-SAbDab Antibody Annotation Thera-SAbDab Database Homepage
Chain | Name | Target | Provenance Source |
---|---|---|---|
I [auth W], J [auth H] | Pateclizumab | LTA | Therapeutic SAbDab (2024-05-03) |
K [auth V], L | Pateclizumab | LTA | Therapeutic SAbDab (2024-05-03) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
A [auth S], H [auth R] | PF00020 | TNFR/NGFR cysteine-rich region (TNFR_c6) | TNFR/NGFR cysteine-rich region | - | Domain |
B [auth X], E [auth A] | PF00229 | TNF(Tumour Necrosis Factor) family (TNF) | TNF(Tumour Necrosis Factor) family | - | Domain |
C [auth Y], D [auth Z], F [auth B], G [auth D] | PF00229 | TNF(Tumour Necrosis Factor) family (TNF) | TNF(Tumour Necrosis Factor) family | - | Domain |