4MWA

1.85 Angstrom Crystal Structure of GCPE Protein from Bacillus anthracis

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	GcpE N-terminal domain-like	8053958	3002254	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	GcpE N-terminal domain-like	8053958	3002254	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	GcpE N-terminal domain-like	8053958	3002254	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	GcpE N-terminal domain-like	8053958	3002254	SCOP2B (2022-06-29)
A	SCOP2 Family	GcpE-like	8046113	4004884	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	GcpE N-terminal domain-like	8053958	3002254	SCOP2 (2022-06-29)
G	SCOP2B Superfamily	GcpE N-terminal domain-like	8053958	3002254	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	GcpE N-terminal domain-like	8053958	3002254	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	GcpE N-terminal domain-like	8053958	3002254	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	PF04551	e4mwaB1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PF04551	ECOD (1.6)
D	PF04551	e4mwaD1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PF04551	ECOD (1.6)
F	PF04551	e4mwaF1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PF04551	ECOD (1.6)
H	PF04551	e4mwaH1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PF04551	ECOD (1.6)
A	PF04551	e4mwaA1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PF04551	ECOD (1.6)
G	PF04551	e4mwaG1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PF04551	ECOD (1.6)
C	PF04551	e4mwaC1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PF04551	ECOD (1.6)
E	PF04551	e4mwaE1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PF04551	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.20.20.20	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Dihydropteroate synthase-like	CATH (4.3.0)
D	3.20.20.20	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Dihydropteroate synthase-like	CATH (4.3.0)
F	3.20.20.20	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Dihydropteroate synthase-like	CATH (4.3.0)
H	3.20.20.20	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Dihydropteroate synthase-like	CATH (4.3.0)
A	3.20.20.20	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Dihydropteroate synthase-like	CATH (4.3.0)
G	3.20.20.20	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Dihydropteroate synthase-like	CATH (4.3.0)
C	3.20.20.20	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Dihydropteroate synthase-like	CATH (4.3.0)
E	3.20.20.20	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Dihydropteroate synthase-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B	PF04551	GcpE protein (GcpE)	GcpE protein	-	Family
D, F, H	PF04551	GcpE protein (GcpE)	GcpE protein	-	Family
A, G	PF04551	GcpE protein (GcpE)	GcpE protein	-	Family
C	PF04551	GcpE protein (GcpE)	GcpE protein	-	Family
E	PF04551	GcpE protein (GcpE)	GcpE protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase	oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulfur protein as acceptor 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity oxidoreductase activity oxidoreductase activity, acting on CH or CH2 groups catalytic activity iron-sulfur cluster binding binding 4 iron, 4 sulfur cluster binding metal cluster binding small molecule binding cation binding transition metal ion binding iron ion binding ion binding oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulfur protein as acceptor 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity oxidoreductase activity oxidoreductase activity, acting on CH or CH2 groups catalytic activity iron-sulfur cluster binding binding 4 iron, 4 sulfur cluster binding metal cluster binding small molecule binding cation binding transition metal ion binding iron ion binding ion binding metal ion binding	cellular biosynthetic process isopentenyl diphosphate biosynthetic process lipid biosynthetic process carbohydrate derivative metabolic process glyceraldehyde-3-phosphate metabolic process phospholipid metabolic process organic substance metabolic process cellular aldehyde metabolic process organic substance biosynthetic process phosphate-containing compound metabolic process phosphorus metabolic process isoprenoid biosynthetic process isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway cellular metabolic process cellular biosynthetic process isopentenyl diphosphate biosynthetic process lipid biosynthetic process carbohydrate derivative metabolic process glyceraldehyde-3-phosphate metabolic process phospholipid metabolic process organic substance metabolic process cellular aldehyde metabolic process organic substance biosynthetic process phosphate-containing compound metabolic process phosphorus metabolic process isoprenoid biosynthetic process isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway cellular metabolic process primary metabolic process phospholipid biosynthetic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process cellular lipid metabolic process metabolic process cellular process lipid metabolic process isoprenoid metabolic process isopentenyl diphosphate metabolic process terpenoid biosynthetic process terpenoid metabolic process	-
D, F, H	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase	oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulfur protein as acceptor 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity oxidoreductase activity oxidoreductase activity, acting on CH or CH2 groups catalytic activity iron-sulfur cluster binding binding 4 iron, 4 sulfur cluster binding metal cluster binding small molecule binding cation binding transition metal ion binding iron ion binding ion binding oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulfur protein as acceptor 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity oxidoreductase activity oxidoreductase activity, acting on CH or CH2 groups catalytic activity iron-sulfur cluster binding binding 4 iron, 4 sulfur cluster binding metal cluster binding small molecule binding cation binding transition metal ion binding iron ion binding ion binding metal ion binding	cellular biosynthetic process isopentenyl diphosphate biosynthetic process lipid biosynthetic process carbohydrate derivative metabolic process glyceraldehyde-3-phosphate metabolic process phospholipid metabolic process organic substance metabolic process cellular aldehyde metabolic process organic substance biosynthetic process phosphate-containing compound metabolic process phosphorus metabolic process isoprenoid biosynthetic process isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway cellular metabolic process cellular biosynthetic process isopentenyl diphosphate biosynthetic process lipid biosynthetic process carbohydrate derivative metabolic process glyceraldehyde-3-phosphate metabolic process phospholipid metabolic process organic substance metabolic process cellular aldehyde metabolic process organic substance biosynthetic process phosphate-containing compound metabolic process phosphorus metabolic process isoprenoid biosynthetic process isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway cellular metabolic process primary metabolic process phospholipid biosynthetic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process cellular lipid metabolic process metabolic process cellular process lipid metabolic process isoprenoid metabolic process isopentenyl diphosphate metabolic process terpenoid biosynthetic process terpenoid metabolic process	-
A, G	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase	oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulfur protein as acceptor 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity oxidoreductase activity oxidoreductase activity, acting on CH or CH2 groups catalytic activity iron-sulfur cluster binding binding 4 iron, 4 sulfur cluster binding metal cluster binding small molecule binding cation binding transition metal ion binding iron ion binding ion binding oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulfur protein as acceptor 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity oxidoreductase activity oxidoreductase activity, acting on CH or CH2 groups catalytic activity iron-sulfur cluster binding binding 4 iron, 4 sulfur cluster binding metal cluster binding small molecule binding cation binding transition metal ion binding iron ion binding ion binding metal ion binding	cellular biosynthetic process isopentenyl diphosphate biosynthetic process lipid biosynthetic process carbohydrate derivative metabolic process glyceraldehyde-3-phosphate metabolic process phospholipid metabolic process organic substance metabolic process cellular aldehyde metabolic process organic substance biosynthetic process phosphate-containing compound metabolic process phosphorus metabolic process isoprenoid biosynthetic process isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway cellular metabolic process cellular biosynthetic process isopentenyl diphosphate biosynthetic process lipid biosynthetic process carbohydrate derivative metabolic process glyceraldehyde-3-phosphate metabolic process phospholipid metabolic process organic substance metabolic process cellular aldehyde metabolic process organic substance biosynthetic process phosphate-containing compound metabolic process phosphorus metabolic process isoprenoid biosynthetic process isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway cellular metabolic process primary metabolic process phospholipid biosynthetic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process cellular lipid metabolic process metabolic process cellular process lipid metabolic process isoprenoid metabolic process isopentenyl diphosphate metabolic process terpenoid biosynthetic process terpenoid metabolic process	-
C	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase	oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulfur protein as acceptor 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity oxidoreductase activity oxidoreductase activity, acting on CH or CH2 groups catalytic activity iron-sulfur cluster binding binding 4 iron, 4 sulfur cluster binding metal cluster binding small molecule binding cation binding transition metal ion binding iron ion binding ion binding oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulfur protein as acceptor 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity oxidoreductase activity oxidoreductase activity, acting on CH or CH2 groups catalytic activity iron-sulfur cluster binding binding 4 iron, 4 sulfur cluster binding metal cluster binding small molecule binding cation binding transition metal ion binding iron ion binding ion binding metal ion binding	cellular biosynthetic process isopentenyl diphosphate biosynthetic process lipid biosynthetic process carbohydrate derivative metabolic process glyceraldehyde-3-phosphate metabolic process phospholipid metabolic process organic substance metabolic process cellular aldehyde metabolic process organic substance biosynthetic process phosphate-containing compound metabolic process phosphorus metabolic process isoprenoid biosynthetic process isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway cellular metabolic process cellular biosynthetic process isopentenyl diphosphate biosynthetic process lipid biosynthetic process carbohydrate derivative metabolic process glyceraldehyde-3-phosphate metabolic process phospholipid metabolic process organic substance metabolic process cellular aldehyde metabolic process organic substance biosynthetic process phosphate-containing compound metabolic process phosphorus metabolic process isoprenoid biosynthetic process isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway cellular metabolic process primary metabolic process phospholipid biosynthetic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process cellular lipid metabolic process metabolic process cellular process lipid metabolic process isoprenoid metabolic process isopentenyl diphosphate metabolic process terpenoid biosynthetic process terpenoid metabolic process	-
E	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase	oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulfur protein as acceptor 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity oxidoreductase activity oxidoreductase activity, acting on CH or CH2 groups catalytic activity iron-sulfur cluster binding binding 4 iron, 4 sulfur cluster binding metal cluster binding small molecule binding cation binding transition metal ion binding iron ion binding ion binding oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulfur protein as acceptor 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity oxidoreductase activity oxidoreductase activity, acting on CH or CH2 groups catalytic activity iron-sulfur cluster binding binding 4 iron, 4 sulfur cluster binding metal cluster binding small molecule binding cation binding transition metal ion binding iron ion binding ion binding metal ion binding	cellular biosynthetic process isopentenyl diphosphate biosynthetic process lipid biosynthetic process carbohydrate derivative metabolic process glyceraldehyde-3-phosphate metabolic process phospholipid metabolic process organic substance metabolic process cellular aldehyde metabolic process organic substance biosynthetic process phosphate-containing compound metabolic process phosphorus metabolic process isoprenoid biosynthetic process isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway cellular metabolic process cellular biosynthetic process isopentenyl diphosphate biosynthetic process lipid biosynthetic process carbohydrate derivative metabolic process glyceraldehyde-3-phosphate metabolic process phospholipid metabolic process organic substance metabolic process cellular aldehyde metabolic process organic substance biosynthetic process phosphate-containing compound metabolic process phosphorus metabolic process isoprenoid biosynthetic process isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway cellular metabolic process primary metabolic process phospholipid biosynthetic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process cellular lipid metabolic process metabolic process cellular process lipid metabolic process isoprenoid metabolic process isopentenyl diphosphate metabolic process terpenoid biosynthetic process terpenoid metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B	IPR016425	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, bacterial	Family
B	IPR011005	Dihydropteroate synthase-like superfamily	Homologous Superfamily
B	IPR045854	Nitrite and sulphite reductase 4Fe-4S domain-like superfamily	Homologous Superfamily
B	IPR004588	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, bacterial-type	Family
D, F, H	IPR016425	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, bacterial	Family
D, F, H	IPR011005	Dihydropteroate synthase-like superfamily	Homologous Superfamily
D, F, H	IPR045854	Nitrite and sulphite reductase 4Fe-4S domain-like superfamily	Homologous Superfamily
D, F, H	IPR004588	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, bacterial-type	Family
A, G	IPR016425	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, bacterial	Family
A, G	IPR011005	Dihydropteroate synthase-like superfamily	Homologous Superfamily
A, G	IPR045854	Nitrite and sulphite reductase 4Fe-4S domain-like superfamily	Homologous Superfamily
A, G	IPR004588	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, bacterial-type	Family
C	IPR016425	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, bacterial	Family
C	IPR011005	Dihydropteroate synthase-like superfamily	Homologous Superfamily
C	IPR045854	Nitrite and sulphite reductase 4Fe-4S domain-like superfamily	Homologous Superfamily
C	IPR004588	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, bacterial-type	Family
E	IPR016425	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, bacterial	Family
E	IPR011005	Dihydropteroate synthase-like superfamily	Homologous Superfamily
E	IPR045854	Nitrite and sulphite reductase 4Fe-4S domain-like superfamily	Homologous Superfamily
E	IPR004588	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, bacterial-type	Family