Annotations: 4MT6

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	DBL homology domain (DH-domain)	8032815	3000793	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	PH domain-like	8032816	3000134	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF22697	e4mt6A2	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: PF22697	ECOD (1.6)
A	PF07653	e4mt6A3	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF07653	ECOD (1.6)
A	PF00621	e4mt6A1	A: alpha bundles	X: DH domain-like	H: DBL homology domain (DH-domain) (From Topology)	T: DBL homology domain (DH-domain)	F: PF00621	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF07653	Variant SH3 domain (SH3_2)	Variant SH3 domain	SH3 (Src homology 3) domains are often indicative of a protein involved in signal transduction related to cytoskeletal organisation. First described in the Src cytoplasmic tyrosine kinase Swiss:P12931. The structure is a partly opened beta barrel.	Domain
A	PF00169	PH domain (PH)	PH domain	PH stands for pleckstrin homology.	Domain
A	PF00621	RhoGEF domain (RhoGEF)	RhoGEF domain	Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that Pfam:PF00169 domains invariably occur C-terminal to RhoGEF/DH domains.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Rho guanine nucleotide exchange factor 9	GTPase regulator activity enzyme regulator activity guanyl-nucleotide exchange factor activity nucleoside-triphosphatase regulator activity molecular function regulator activity	protein localization localization cellular localization receptor clustering cellular macromolecule localization macromolecule localization cellular process localization within membrane protein localization to membrane multicellular organismal process regulation of cellular process regulation of cellular component organization regulation of postsynaptic specialization assembly cellular component organization protein localization localization cellular localization receptor clustering cellular macromolecule localization macromolecule localization cellular process localization within membrane protein localization to membrane multicellular organismal process regulation of cellular process regulation of cellular component organization regulation of postsynaptic specialization assembly cellular component organization cellular component biogenesis multicellular organism development cellular component assembly cell junction assembly anatomical structure development synapse organization cellular component organization or biogenesis system development developmental process regulation of biological process postsynapse organization organelle assembly postsynaptic specialization assembly postsynapse assembly biological regulation nervous system development regulation of cellular component biogenesis regulation of organelle organization organelle organization cell junction organization regulation of organelle assembly postsynaptic specialization organization synapse assembly	cell periphery cell cortex intracellular anatomical structure cytoplasm cellular anatomical entity cytosol postsynaptic density postsynapse neuron to neuron synapse postsynaptic specialization organelle synapse cell junction asymmetric synapse cell periphery cell cortex intracellular anatomical structure cytoplasm cellular anatomical entity cytosol postsynaptic density postsynapse neuron to neuron synapse postsynaptic specialization organelle synapse cell junction asymmetric synapse glycinergic synapse plasma membrane membrane GABA-ergic synapse

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001849	Pleckstrin homology domain	Domain
A	IPR000219	Dbl homology (DH) domain	Domain
A	IPR035728	Rho guanine nucleotide exchange factor 9, SH3 domain	Domain
A	IPR001452	SH3 domain	Domain
A	IPR036028	SH3-like domain superfamily	Homologous Superfamily
A	IPR035899	Dbl homology (DH) domain superfamily	Homologous Superfamily
A	IPR011993	PH-like domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.