4MHJ

Crystal structure of Fab H5M9 in complex with influenza virus hemagglutinin from A/goose/Guangdong/1/96 (H5N1)

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
IMGT Antibody Annotation
SAbDab Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C	SCOP2B Superfamily	Influenza hemagglutinin domain-like	8087734	3001342	SCOP2B (2022-06-29)
E [auth G]	SCOP2B Superfamily	Influenza hemagglutinin domain-like	8087734	3001342	SCOP2B (2022-06-29)
F [auth M]	SCOP2B Superfamily	Influenza hemagglutinin domain-like	8087734	3001342	SCOP2B (2022-06-29)
H [auth O]	SCOP2B Superfamily	Influenza hemagglutinin domain-like	8087734	3001342	SCOP2B (2022-06-29)
J [auth S]	SCOP2B Superfamily	Influenza hemagglutinin domain-like	8087734	3001342	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Influenza hemagglutinin domain-like	8087734	3001342	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Influenza hemagglutinin (stalk)	8087952	3001616	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Influenza hemagglutinin (stalk)	8087952	3001616	SCOP2B (2022-06-29)
G [auth N]	SCOP2B Superfamily	Influenza hemagglutinin (stalk)	8087952	3001616	SCOP2B (2022-06-29)
I [auth P]	SCOP2B Superfamily	Influenza hemagglutinin (stalk)	8087952	3001616	SCOP2B (2022-06-29)
Q [auth I]	SCOP2B Superfamily	Influenza hemagglutinin (stalk)	8087952	3001616	SCOP2B (2022-06-29)
R [auth U]	SCOP2B Superfamily	Influenza hemagglutinin (stalk)	8087952	3001616	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C	Hemagglutinin_1st	e4mhjC1	A: beta sandwiches	X: jelly-roll	H: Viral protein domain (From Topology)	T: Viral protein domain	F: Hemagglutinin_1st	ECOD (1.6)
E [auth G]	Hemagglutinin_1st	e4mhjG1	A: beta sandwiches	X: jelly-roll	H: Viral protein domain (From Topology)	T: Viral protein domain	F: Hemagglutinin_1st	ECOD (1.6)
F [auth M]	Hemagglutinin_1st	e4mhjM1	A: beta sandwiches	X: jelly-roll	H: Viral protein domain (From Topology)	T: Viral protein domain	F: Hemagglutinin_1st	ECOD (1.6)
H [auth O]	Hemagglutinin_1st	e4mhjO1	A: beta sandwiches	X: jelly-roll	H: Viral protein domain (From Topology)	T: Viral protein domain	F: Hemagglutinin_1st	ECOD (1.6)
J [auth S]	Hemagglutinin_1st	e4mhjS1	A: beta sandwiches	X: jelly-roll	H: Viral protein domain (From Topology)	T: Viral protein domain	F: Hemagglutinin_1st	ECOD (1.6)
A	Hemagglutinin_1st	e4mhjA1	A: beta sandwiches	X: jelly-roll	H: Viral protein domain (From Topology)	T: Viral protein domain	F: Hemagglutinin_1st	ECOD (1.6)
K [auth L]	C1-set_4	e4mhjL1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_4	ECOD (1.6)
K [auth L]	V-set	e4mhjL2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)
L [auth E]	C1-set_4	e4mhjE1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_4	ECOD (1.6)
L [auth E]	V-set	e4mhjE2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)
M [auth J]	C1-set_4	e4mhjJ1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_4	ECOD (1.6)
M [auth J]	V-set	e4mhjJ2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)
N [auth X]	C1-set_4	e4mhjX1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_4	ECOD (1.6)
N [auth X]	V-set	e4mhjX2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)
O [auth Q]	C1-set_4	e4mhjQ1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_4	ECOD (1.6)
O [auth Q]	V-set	e4mhjQ2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)
P [auth V]	C1-set_4	e4mhjV1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_4	ECOD (1.6)
P [auth V]	V-set	e4mhjV2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)
S [auth H]	V-set_8	e4mhjH2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_8	ECOD (1.6)
S [auth H]	C1-set_1	e4mhjH1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_1	ECOD (1.6)
T [auth F]	V-set_8	e4mhjF2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_8	ECOD (1.6)
T [auth F]	C1-set_1	e4mhjF1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_1	ECOD (1.6)
U [auth K]	V-set_8	e4mhjK2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_8	ECOD (1.6)
U [auth K]	C1-set_1	e4mhjK1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_1	ECOD (1.6)
V [auth T]	V-set_8	e4mhjT2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_8	ECOD (1.6)
V [auth T]	C1-set_1	e4mhjT1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_1	ECOD (1.6)
W [auth R]	V-set_8	e4mhjR2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_8	ECOD (1.6)
W [auth R]	C1-set_1	e4mhjR1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_1	ECOD (1.6)
X [auth W]	V-set_8	e4mhjW2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_8	ECOD (1.6)
X [auth W]	C1-set_1	e4mhjW1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_1	ECOD (1.6)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
K [auth L], L [auth E], M [auth J], N [auth X], O [auth Q], K [auth L], L [auth E], M [auth J], N [auth X], O [auth Q], P [auth V]	H5M9 Fab	L-KAPPA	Mus musculus (house mouse)	IGKV3-501, IGKJ101, IGKJ102, IGKJ201, IGKC01, IGKC02	V-DOMAIN V-KAPPA, C-DOMAIN C-KAPPA	IG	FAB-GAMMA-1_KAPPA	IMGT (202415-0)
S [auth H], T [auth F], U [auth K], V [auth T], W [auth R], S [auth H], T [auth F], U [auth K], V [auth T], W [auth R], X [auth W]	H5M9 Fab	VH-CH1	Mus musculus (house mouse)	IGHV1-2201, IGHJ101, IGHJ102, IGHG102	V-DOMAIN VH, C-DOMAIN CH1	IG	FAB-GAMMA-1_KAPPA	IMGT (202415-0)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
K [auth L], L [auth E], M [auth J], N [auth X], O [auth Q], K [auth L], L [auth E], M [auth J], N [auth X], O [auth Q], P [auth V]	Light Chain	IGKV3	Kappa	hemagglutinin ha1 chain	SAbDab (2024-04-19)
S [auth H], T [auth F], U [auth K], V [auth T], W [auth R], S [auth H], T [auth F], U [auth K], V [auth T], W [auth R], X [auth W]	Heavy Chain	IGHV1	-	hemagglutinin ha1 chain	SAbDab (2024-04-19)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C, E [auth G], F [auth M], H [auth O], A, C, E [auth G], F [auth M], H [auth O], J [auth S]	PF00509	Haemagglutinin (Hemagglutinin)	Haemagglutinin	-	Family
B, D, G [auth N], I [auth P], Q [auth I], B, D, G [auth N], I [auth P], Q [auth I], R [auth U]	PF00509	Haemagglutinin (Hemagglutinin)	Haemagglutinin	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C, E [auth G], F [auth M], H [auth O], A, C, E [auth G], F [auth M], H [auth O], J [auth S]	Hemagglutinin HA1 chain	host cell surface binding binding host cell surface receptor binding	viral process fusion of virus membrane with host endosome membrane membrane fusion involved in viral entry into host cell membrane organization cellular component organization membrane fusion fusion of virus membrane with host plasma membrane cellular process cellular component organization or biogenesis virion attachment to host cell biological process involved in interspecies interaction between organisms adhesion of symbiont to host cell viral life cycle adhesion of symbiont to host viral process fusion of virus membrane with host endosome membrane membrane fusion involved in viral entry into host cell membrane organization cellular component organization membrane fusion fusion of virus membrane with host plasma membrane cellular process cellular component organization or biogenesis virion attachment to host cell biological process involved in interspecies interaction between organisms adhesion of symbiont to host cell viral life cycle adhesion of symbiont to host biological process involved in interaction with host biological process involved in symbiotic interaction non-lytic viral release viral budding virion assembly exit from host cell viral budding from plasma membrane viral release from host cell import into cell receptor-mediated endocytosis of virus by host cell transport establishment of localization vesicle-mediated transport localization symbiont entry into host cell clathrin-dependent endocytosis symbiont entry into host clathrin-dependent endocytosis of virus by host cell receptor-mediated endocytosis endocytosis endocytosis involved in viral entry into host cell transport of virus	membrane cellular anatomical entity virion component virion membrane viral membrane viral envelope host cell plasma membrane host cellular component host cell part host cell membrane
B, D, G [auth N], I [auth P], Q [auth I], B, D, G [auth N], I [auth P], Q [auth I], R [auth U]	Hemagglutinin HA2 chain	host cell surface binding binding host cell surface receptor binding	viral process fusion of virus membrane with host endosome membrane membrane fusion involved in viral entry into host cell membrane organization cellular component organization membrane fusion fusion of virus membrane with host plasma membrane cellular process cellular component organization or biogenesis virion attachment to host cell biological process involved in interspecies interaction between organisms adhesion of symbiont to host cell viral life cycle adhesion of symbiont to host viral process fusion of virus membrane with host endosome membrane membrane fusion involved in viral entry into host cell membrane organization cellular component organization membrane fusion fusion of virus membrane with host plasma membrane cellular process cellular component organization or biogenesis virion attachment to host cell biological process involved in interspecies interaction between organisms adhesion of symbiont to host cell viral life cycle adhesion of symbiont to host biological process involved in interaction with host biological process involved in symbiotic interaction non-lytic viral release viral budding virion assembly exit from host cell viral budding from plasma membrane viral release from host cell import into cell receptor-mediated endocytosis of virus by host cell transport establishment of localization vesicle-mediated transport localization symbiont entry into host cell clathrin-dependent endocytosis symbiont entry into host clathrin-dependent endocytosis of virus by host cell receptor-mediated endocytosis endocytosis endocytosis involved in viral entry into host cell transport of virus	membrane cellular anatomical entity virion component virion membrane viral membrane viral envelope host cell plasma membrane host cellular component host cell part host cell membrane
K [auth L], L [auth E], M [auth J], N [auth X], O [auth Q], K [auth L], L [auth E], M [auth J], N [auth X], O [auth Q], P [auth V]	H5M9 antibody, light chain (kappa)	-	-	-
S [auth H], T [auth F], U [auth K], V [auth T], W [auth R], S [auth H], T [auth F], U [auth K], V [auth T], W [auth R], X [auth W]	H5M9 antibody, heavy chain (IgG1)	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C, E [auth G], F [auth M], H [auth O], A, C, E [auth G], F [auth M], H [auth O], J [auth S]	IPR001364	Haemagglutinin, influenzavirus A/B	Family
A, C, E [auth G], F [auth M], H [auth O], A, C, E [auth G], F [auth M], H [auth O], J [auth S]	IPR008980	Viral capsid/haemagglutinin protein	Homologous Superfamily
A, C, E [auth G], F [auth M], H [auth O], A, C, E [auth G], F [auth M], H [auth O], J [auth S]	IPR000149	Haemagglutinin, influenzavirus A	Family
A, C, E [auth G], F [auth M], H [auth O], A, C, E [auth G], F [auth M], H [auth O], J [auth S]	IPR013828	Haemagglutinin, HA1 chain, alpha/beta domain superfamily	Homologous Superfamily
B, D, G [auth N], I [auth P], Q [auth I], B, D, G [auth N], I [auth P], Q [auth I], R [auth U]	IPR001364	Haemagglutinin, influenzavirus A/B	Family
B, D, G [auth N], I [auth P], Q [auth I], B, D, G [auth N], I [auth P], Q [auth I], R [auth U]	IPR008980	Viral capsid/haemagglutinin protein	Homologous Superfamily
B, D, G [auth N], I [auth P], Q [auth I], B, D, G [auth N], I [auth P], Q [auth I], R [auth U]	IPR000149	Haemagglutinin, influenzavirus A	Family
B, D, G [auth N], I [auth P], Q [auth I], B, D, G [auth N], I [auth P], Q [auth I], R [auth U]	IPR013828	Haemagglutinin, HA1 chain, alpha/beta domain superfamily	Homologous Superfamily

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4MHJ

Crystal structure of Fab H5M9 in complex with influenza virus hemagglutinin from A/goose/Guangdong/1/96 (H5N1)

External Resource: Annotation

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Domain Annotation: ECOD Classification ECOD Database Homepage

IMGT Antibody Annotation IMGT Database Homepage

SAbDab Antibody Annotation SAbDab Database Homepage

Protein Family Annotation Pfam Database Homepage

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

InterPro: Protein Family Classification InterPro Database Homepage