Annotations: 4M8G

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Thioredoxin-like	8095961	3000031	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Thioredoxin-like	8095961	3000031	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF04756	e4m8gA1	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: PF04756	ECOD (1.6)
B	PF04756	e4m8gB1	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: PF04756	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF04756	OST3 / OST6 family, transporter family (OST3_OST6)	OST3 / OST6 family, transporter family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Tumor suppressor candidate 3	monoatomic cation transmembrane transporter activity magnesium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity	localization transport magnesium ion transport monoatomic ion transport monoatomic cation transport establishment of localization metal ion transport cellular biosynthetic process organonitrogen compound biosynthetic process carbohydrate derivative metabolic process organic substance metabolic process organic substance biosynthetic process protein metabolic process protein modification process localization transport magnesium ion transport monoatomic ion transport monoatomic cation transport establishment of localization metal ion transport cellular biosynthetic process organonitrogen compound biosynthetic process carbohydrate derivative metabolic process organic substance metabolic process organic substance biosynthetic process protein metabolic process protein modification process carbohydrate derivative biosynthetic process organonitrogen compound metabolic process cellular metabolic process glycoprotein biosynthetic process primary metabolic process glycoprotein metabolic process protein N-linked glycosylation protein glycosylation macromolecule biosynthetic process biosynthetic process glycosylation macromolecule modification macromolecule glycosylation metabolic process cellular process macromolecule metabolic process multicellular organismal process system process nervous system process cognition protein N-linked glycosylation via asparagine transmembrane transport	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle protein-containing complex catalytic complex organelle subcompartment oligosaccharyltransferase complex membrane membrane protein complex membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle protein-containing complex catalytic complex organelle subcompartment oligosaccharyltransferase complex membrane membrane protein complex transferase complex endomembrane system endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum organelle membrane endoplasmic reticulum protein-containing complex endoplasmic reticulum membrane cell periphery plasma membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR021149	Oligosaccharyl transferase complex, subunit OST3/OST6	Family
A, B	IPR036249	Thioredoxin-like superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q13454	intellectual disability, autosomal recessive 7 intellectual disability Liver Cirrhosis, Experimental subependymal giant cell astrocytoma adenoma breast cancer glioblastoma interstitial cystitis lung carcinoma osteosarcoma Pick disease ulcerative colitis astrocytic tumor congenital disorder of glycosylation malignant glioma intellectual disability, autosomal recessive 7 intellectual disability Liver Cirrhosis, Experimental subependymal giant cell astrocytoma adenoma breast cancer glioblastoma interstitial cystitis lung carcinoma osteosarcoma Pick disease ulcerative colitis astrocytic tumor congenital disorder of glycosylation malignant glioma ovarian cancer psoriasis atypical teratoid rhabdoid tumor Duchenne muscular dystrophy lung cancer oligodendroglioma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.