4M81

The structure of E292S glycosynthase variant of exo-1,3-beta-glucanase from Candida albicans complexed with 1-fluoro-alpha-D-glucopyranoside (donor) and p-nitrophenyl beta-D-glucopyranoside (acceptor) at 1.86A resolution

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4m81a_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	(Trans)glycosidases	beta-glycanases	automated matches	yeast (Candida albicans SC5314 ) [TaxId: 237561 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	(Trans)glycosidases	8043855	3000313	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Cellulase	e4m81A1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Cellulase	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.20.20.80	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Glycosidases	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00150	Cellulase (glycosyl hydrolase family 5) (Cellulase)	Cellulase (glycosyl hydrolase family 5)	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	EXO-1,3-BETA-GLUCANASE	glucan exo-1,3-beta-glucosidase activity hydrolase activity, acting on glycosyl bonds glucosidase activity hydrolase activity, hydrolyzing O-glycosyl compounds hydrolase activity beta-glucosidase activity catalytic activity cell adhesion molecule binding protein binding binding transferase activity	carbohydrate metabolic process glucan metabolic process polysaccharide metabolic process organic substance metabolic process metabolic process primary metabolic process macromolecule metabolic process catabolic process glucan catabolic process carbohydrate catabolic process macromolecule catabolic process polysaccharide catabolic process organic substance catabolic process fungal-type cell wall organization carbohydrate metabolic process glucan metabolic process polysaccharide metabolic process organic substance metabolic process metabolic process primary metabolic process macromolecule metabolic process catabolic process glucan catabolic process carbohydrate catabolic process macromolecule catabolic process polysaccharide catabolic process organic substance catabolic process fungal-type cell wall organization cellular component organization fungal-type cell wall organization or biogenesis cell wall organization or biogenesis cell wall organization cellular process cellular component organization or biogenesis external encapsulating structure organization cell adhesion cell-substrate adhesion cell aggregation biological process involved in interspecies interaction between organisms biofilm formation biological process involved in intraspecies interaction between organisms single-species biofilm formation in or on host organism single-species biofilm formation adhesion of symbiont to host biological process involved in interaction with host aggregation of unicellular organisms biological process involved in symbiotic interaction single-species biofilm formation on inanimate substrate single-species submerged biofilm formation submerged biofilm formation	extracellular region cellular anatomical entity membrane-bounded organelle extracellular vesicle extracellular organelle organelle vesicle extracellular membrane-bounded organelle cell surface

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR017853	Glycoside hydrolase superfamily	Homologous Superfamily
A	IPR001547	Glycoside hydrolase, family 5	Domain
A	IPR018087	Glycoside hydrolase, family 5, conserved site	Conserved Site

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.