4M0G

The crystal structure of an adenylosuccinate synthetase from Bacillus anthracis str. Ames Ancestor.

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4m0ga1	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	automated matches	automated matches	anthrax,anthrax bacterium (Bacillus anthracis str. 'Ames Ancestor ) [TaxId: 261594 ],	SCOPe (2.08)
A	d4m0ga2	Artifacts	Tags	Tags	Tags	N-terminal Tags	anthrax,anthrax bacterium (Bacillus anthracis str. 'Ames Ancestor ) [TaxId: 261594 ],	SCOPe (2.08)
B	d4m0gb_	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	automated matches	automated matches	anthrax,anthrax bacterium (Bacillus anthracis str. 'Ames Ancestor ) [TaxId: 261594 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00709	e4m0gA1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00709	ECOD (1.6)
B	PF00709	e4m0gB1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00709	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.440.10	Alpha Beta	3-Layer(aba) Sandwich	Adenylosuccinate Synthetase	Chain A, domain 1	CATH (4.3.0)
A	1.10.300.10	Mainly Alpha	Orthogonal Bundle	Adenylosuccinate Synthetase, subunit A	domain 2	CATH (4.3.0)
A	3.90.170.10	Alpha Beta	Alpha-Beta Complex	Adenylosuccinate Synthetase	Chain A, domain 3	CATH (4.3.0)
B	3.40.440.10	Alpha Beta	3-Layer(aba) Sandwich	Adenylosuccinate Synthetase	Chain A, domain 1	CATH (4.3.0)
B	1.10.300.10	Mainly Alpha	Orthogonal Bundle	Adenylosuccinate Synthetase, subunit A	domain 2	CATH (4.3.0)
B	3.90.170.10	Alpha Beta	Alpha-Beta Complex	Adenylosuccinate Synthetase	Chain A, domain 3	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00709	Adenylosuccinate synthetase (Adenylsucc_synt)	Adenylosuccinate synthetase	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Adenylosuccinate synthetase	cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding organic cyclic compound binding cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding organic cyclic compound binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding adenylosuccinate synthase activity catalytic activity ligase activity, forming carbon-nitrogen bonds ligase activity	ribose phosphate metabolic process 'de novo' AMP biosynthetic process purine ribonucleoside monophosphate biosynthetic process nucleotide biosynthetic process organonitrogen compound biosynthetic process carbohydrate derivative metabolic process purine ribonucleotide biosynthetic process AMP metabolic process nucleobase-containing compound metabolic process ribonucleotide biosynthetic process purine nucleoside monophosphate biosynthetic process purine ribonucleoside monophosphate metabolic process purine nucleotide metabolic process organic substance metabolic process ribonucleotide metabolic process ribose phosphate metabolic process 'de novo' AMP biosynthetic process purine ribonucleoside monophosphate biosynthetic process nucleotide biosynthetic process organonitrogen compound biosynthetic process carbohydrate derivative metabolic process purine ribonucleotide biosynthetic process AMP metabolic process nucleobase-containing compound metabolic process ribonucleotide biosynthetic process purine nucleoside monophosphate biosynthetic process purine ribonucleoside monophosphate metabolic process purine nucleotide metabolic process organic substance metabolic process ribonucleotide metabolic process ribonucleoside monophosphate metabolic process nucleobase-containing small molecule metabolic process purine-containing compound biosynthetic process purine nucleoside monophosphate metabolic process phosphate-containing compound metabolic process organic substance biosynthetic process small molecule metabolic process phosphorus metabolic process ribose phosphate biosynthetic process nucleoside monophosphate metabolic process nucleoside phosphate metabolic process carbohydrate derivative biosynthetic process organonitrogen compound metabolic process cellular metabolic process primary metabolic process nucleotide metabolic process nucleobase-containing compound biosynthetic process nucleoside monophosphate biosynthetic process purine-containing compound metabolic process organic cyclic compound metabolic process biosynthetic process organophosphate metabolic process AMP biosynthetic process organophosphate biosynthetic process organic cyclic compound biosynthetic process nucleoside phosphate biosynthetic process metabolic process cellular process purine ribonucleotide metabolic process ribonucleoside monophosphate biosynthetic process purine nucleotide biosynthetic process	intracellular anatomical structure cytoplasm cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR001114	Adenylosuccinate synthetase	Family
A, B	IPR033128	Adenylosuccinate synthase, active site	Active Site
A, B	IPR042110	Adenylosuccinate synthetase, domain 2	Homologous Superfamily
A, B	IPR018220	Adenylosuccinate synthase, GTP-binding site	Binding Site
A, B	IPR042111	Adenylosuccinate synthetase, domain 3	Homologous Superfamily
A, B	IPR042109	Adenylosuccinate synthetase, domain 1	Homologous Superfamily
A, B	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.