4LWC

Fragment-Based Discovery of a Potent Inhibitor of Replication Protein A Protein-Protein Interactions

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4lwca1	All beta proteins	OB-fold	Nucleic acid-binding proteins	Single strand DNA-binding domain, SSB	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d4lwca2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Nucleic acid-binding proteins	8037540	3000135	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Rep-A_N	e4lwcA1	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: Rep-A_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.40.50.140	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	Nucleic acid-binding proteins	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF04057	Replication factor-A protein 1, N-terminal domain (Rep-A_N)	Replication factor-A protein 1, N-terminal domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Replication protein A 70 kDa DNA-binding subunit	chromatin-protein adaptor activity protein-macromolecule adaptor activity molecular adaptor activity DNA binding binding organic cyclic compound binding damaged DNA binding nucleic acid binding sequence-specific DNA binding G-rich strand telomeric DNA binding sequence-specific single stranded DNA binding single-stranded telomeric DNA binding single-stranded DNA binding telomeric DNA binding chromatin-protein adaptor activity protein-macromolecule adaptor activity molecular adaptor activity DNA binding binding organic cyclic compound binding damaged DNA binding nucleic acid binding sequence-specific DNA binding G-rich strand telomeric DNA binding sequence-specific single stranded DNA binding single-stranded telomeric DNA binding single-stranded DNA binding telomeric DNA binding cation binding ion binding metal ion binding small molecule binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process protein localization localization cellular localization protein localization to chromosome protein localization to organelle cellular macromolecule localization macromolecule localization cellular biosynthetic process telomere organization RNA-templated DNA biosynthetic process telomere maintenance via telomere lengthening cellular component organization nucleic acid biosynthetic process organic substance biosynthetic process cellular component organization or biogenesis telomere maintenance via telomerase cellular metabolic process chromosome organization nucleobase-containing compound biosynthetic process macromolecule biosynthetic process telomere maintenance organelle organization biosynthetic process organic cyclic compound biosynthetic process DNA biosynthetic process mismatch repair DNA repair DNA-templated DNA replication protein localization to site of double-strand break DNA recombination double-strand break repair recombinational repair double-strand break repair via homologous recombination base-excision repair nucleotide-excision repair sexual reproduction reproductive process meiotic cell cycle cell cycle	membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular organelle lumen intracellular organelle nuclear replisome replication fork non-membrane-bounded organelle DNA replication factor A complex membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular organelle lumen intracellular organelle nuclear replisome replication fork non-membrane-bounded organelle DNA replication factor A complex protein-DNA complex nuclear replication fork intracellular membrane-bounded organelle cellular anatomical entity organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen replisome nucleoplasm site of double-strand break site of DNA damage chromosome, telomeric region chromosomal region nuclear body PML body

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR007199	Replication factor-A protein 1, N-terminal	Domain
A	IPR047192	Replication factor A, C-terminal, eukaryotes	Domain
A	IPR013955	Replication factor A, C-terminal	Domain
A	IPR031657	Replication protein A, OB domain	Domain
A	IPR004365	OB-fold nucleic acid binding domain, AA-tRNA synthetase-type	Domain
A	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
A	IPR004591	Replication factor A protein 1	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P27694	Chloracne astrocytic tumor breast cancer glioblastoma malignant ependymoma ovarian cancer atypical teratoid rhabdoid tumor Hodgkins lymphoma malignant mesothelioma psoriasis B-cell chronic lymphocytic leukemia dermatomyositis lymphoplasmacytic lymphoma medulloblastoma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.