Annotations: 4LSZ

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00656	e4lszA1	A: a/b three-layered sandwiches	X: Caspase-like (From Topology)	H: Caspase-like (From Topology)	T: Caspase-like	F: PF00656	ECOD (1.6)
C	PF00656	e4lszC1	A: a/b three-layered sandwiches	X: Caspase-like (From Topology)	H: Caspase-like (From Topology)	T: Caspase-like	F: PF00656	ECOD (1.6)
B	PF00656	e4lszB1	A: a/b three-layered sandwiches	X: Caspase-like (From Topology)	H: Caspase-like (From Topology)	T: Caspase-like	F: PF00656	ECOD (1.6)
D	PF00656	e4lszD1	A: a/b three-layered sandwiches	X: Caspase-like (From Topology)	H: Caspase-like (From Topology)	T: Caspase-like	F: PF00656	ECOD (1.6)
E	PF00023	e4lszE1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Ankyrin repeat (From Topology)	T: Ankyrin repeat	F: PF00023	ECOD (1.6)
F	PF00023	e4lszF1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Ankyrin repeat (From Topology)	T: Ankyrin repeat	F: PF00023	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.1460	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
C	3.40.50.1460	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
B	3.30.70.1470	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	Caspase-like	CATH (4.3.0)
D	3.30.70.1470	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	Caspase-like	CATH (4.3.0)
E	1.25.40.20	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat	Ankyrin repeat-containing domain	CATH (4.3.0)
F	1.25.40.20	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat	Ankyrin repeat-containing domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C	PF00656	Caspase domain (Peptidase_C14)	Caspase domain	-	Domain
B, D	PF00656	Caspase domain (Peptidase_C14)	Caspase domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	Caspase-7 subunit p20	peptidase activity catalytic activity, acting on a protein hydrolase activity catalytic activity cysteine-type peptidase activity cysteine-type endopeptidase activity endopeptidase activity cysteine-type endopeptidase activity involved in execution phase of apoptosis cysteine-type endopeptidase activity involved in apoptotic process RNA binding binding organic cyclic compound binding nucleic acid binding aspartic-type peptidase activity peptidase activity catalytic activity, acting on a protein hydrolase activity catalytic activity cysteine-type peptidase activity cysteine-type endopeptidase activity endopeptidase activity cysteine-type endopeptidase activity involved in execution phase of apoptosis cysteine-type endopeptidase activity involved in apoptotic process RNA binding binding organic cyclic compound binding nucleic acid binding aspartic-type peptidase activity aspartic-type endopeptidase activity	developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development circulatory system development system development cellular process apoptotic process cell death programmed cell death organonitrogen compound catabolic process organonitrogen compound metabolic process developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development circulatory system development system development cellular process apoptotic process cell death programmed cell death organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process cellular response to stimulus response to organic substance biological process involved in interspecies interaction between organisms response to stimulus response to lipid response to other organism cellular response to lipopolysaccharide response to oxygen-containing compound response to external stimulus cellular response to molecule of bacterial origin response to lipopolysaccharide cellular response to oxygen-containing compound response to biotic stimulus cellular response to biotic stimulus cellular response to chemical stimulus response to chemical response to bacterium cellular response to lipid cellular response to organic substance response to external biotic stimulus response to molecule of bacterial origin lymphocyte apoptotic process leukocyte apoptotic process execution phase of apoptosis cellular biosynthetic process cellular metabolic process gene expression macromolecule biosynthetic process protein maturation biosynthetic process proteolysis organic substance biosynthetic process protein processing defense response defense response to bacterium defense response to other organism response to stress fibroblast apoptotic process cellular response to nitrogen compound cellular response to staurosporine response to organonitrogen compound response to endogenous stimulus cellular response to organic cyclic compound response to staurosporine response to nitrogen compound response to alkaloid cellular response to endogenous stimulus cellular response to organonitrogen compound cellular response to alkaloid response to organic cyclic compound membrane organization regulation of biological process wound healing regulation of cellular component organization regulation of cellular process positive regulation of cellular component organization plasma membrane repair biological regulation positive regulation of biological process cellular component organization regulation of plasma membrane organization plasma membrane organization regulation of plasma membrane repair cellular component organization or biogenesis positive regulation of plasma membrane repair response to wounding endomembrane system organization positive regulation of cellular process neuron apoptotic process response to light stimulus response to radiation response to abiotic stimulus response to UV muscle structure development cellular developmental process cell differentiation striated muscle cell differentiation muscle cell differentiation	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen extracellular region extracellular space
B, D	Caspase-7 subunit p10	peptidase activity catalytic activity, acting on a protein hydrolase activity catalytic activity cysteine-type peptidase activity cysteine-type endopeptidase activity endopeptidase activity cysteine-type endopeptidase activity involved in execution phase of apoptosis cysteine-type endopeptidase activity involved in apoptotic process RNA binding binding organic cyclic compound binding nucleic acid binding aspartic-type peptidase activity peptidase activity catalytic activity, acting on a protein hydrolase activity catalytic activity cysteine-type peptidase activity cysteine-type endopeptidase activity endopeptidase activity cysteine-type endopeptidase activity involved in execution phase of apoptosis cysteine-type endopeptidase activity involved in apoptotic process RNA binding binding organic cyclic compound binding nucleic acid binding aspartic-type peptidase activity aspartic-type endopeptidase activity	developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development circulatory system development system development cellular process apoptotic process cell death programmed cell death organonitrogen compound catabolic process organonitrogen compound metabolic process developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development circulatory system development system development cellular process apoptotic process cell death programmed cell death organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process cellular response to stimulus response to organic substance biological process involved in interspecies interaction between organisms response to stimulus response to lipid response to other organism cellular response to lipopolysaccharide response to oxygen-containing compound response to external stimulus cellular response to molecule of bacterial origin response to lipopolysaccharide cellular response to oxygen-containing compound response to biotic stimulus cellular response to biotic stimulus cellular response to chemical stimulus response to chemical response to bacterium cellular response to lipid cellular response to organic substance response to external biotic stimulus response to molecule of bacterial origin lymphocyte apoptotic process leukocyte apoptotic process execution phase of apoptosis cellular biosynthetic process cellular metabolic process gene expression macromolecule biosynthetic process protein maturation biosynthetic process proteolysis organic substance biosynthetic process protein processing defense response defense response to bacterium defense response to other organism response to stress fibroblast apoptotic process cellular response to nitrogen compound cellular response to staurosporine response to organonitrogen compound response to endogenous stimulus cellular response to organic cyclic compound response to staurosporine response to nitrogen compound response to alkaloid cellular response to endogenous stimulus cellular response to organonitrogen compound cellular response to alkaloid response to organic cyclic compound membrane organization regulation of biological process wound healing regulation of cellular component organization regulation of cellular process positive regulation of cellular component organization plasma membrane repair biological regulation positive regulation of biological process cellular component organization regulation of plasma membrane organization plasma membrane organization regulation of plasma membrane repair cellular component organization or biogenesis positive regulation of plasma membrane repair response to wounding endomembrane system organization positive regulation of cellular process neuron apoptotic process response to light stimulus response to radiation response to abiotic stimulus response to UV muscle structure development cellular developmental process cell differentiation striated muscle cell differentiation muscle cell differentiation	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen extracellular region extracellular space
E, F	DARPin D7.18	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C	IPR001309	Peptidase C14, p20 domain	Domain
A, C	IPR011600	Peptidase C14, caspase domain	Domain
A, C	IPR016129	Peptidase family C14A, His active site	Active Site
A, C	IPR015917	Peptidase C14A, caspase catalytic domain	Domain
A, C	IPR029030	Caspase-like domain superfamily	Homologous Superfamily
A, C	IPR033139	Peptidase family C14A, cysteine active site	Active Site
A, C	IPR002138	Peptidase C14, caspase non-catalytic subunit p10	Domain
B, D	IPR001309	Peptidase C14, p20 domain	Domain
B, D	IPR011600	Peptidase C14, caspase domain	Domain
B, D	IPR016129	Peptidase family C14A, His active site	Active Site
B, D	IPR015917	Peptidase C14A, caspase catalytic domain	Domain
B, D	IPR029030	Caspase-like domain superfamily	Homologous Superfamily
B, D	IPR033139	Peptidase family C14A, cysteine active site	Active Site
B, D	IPR002138	Peptidase C14, caspase non-catalytic subunit p10	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, C	Pharos: P55210	vitiligo acute myeloid leukemia breast carcinoma Myocardial Reperfusion Injury pancreatic intraductal papillary-mucinous carcinoma attention deficit hyperactivity disorder, inattentive type juvenile dermatomyositis lung carcinoma medulloblastoma pancreatic intraductal papillary-mucinous neoplasm Barrett esophagus cancer large cell medulloblastoma malignant colon neoplasm psoriasis vitiligo acute myeloid leukemia breast carcinoma Myocardial Reperfusion Injury pancreatic intraductal papillary-mucinous carcinoma attention deficit hyperactivity disorder, inattentive type juvenile dermatomyositis lung carcinoma medulloblastoma pancreatic intraductal papillary-mucinous neoplasm Barrett esophagus cancer large cell medulloblastoma malignant colon neoplasm psoriasis breast cancer esophageal adenocarcinoma malignant glioma
B, D	Pharos: P55210	vitiligo acute myeloid leukemia breast carcinoma Myocardial Reperfusion Injury pancreatic intraductal papillary-mucinous carcinoma attention deficit hyperactivity disorder, inattentive type juvenile dermatomyositis lung carcinoma medulloblastoma pancreatic intraductal papillary-mucinous neoplasm Barrett esophagus cancer large cell medulloblastoma malignant colon neoplasm psoriasis vitiligo acute myeloid leukemia breast carcinoma Myocardial Reperfusion Injury pancreatic intraductal papillary-mucinous carcinoma attention deficit hyperactivity disorder, inattentive type juvenile dermatomyositis lung carcinoma medulloblastoma pancreatic intraductal papillary-mucinous neoplasm Barrett esophagus cancer large cell medulloblastoma malignant colon neoplasm psoriasis breast cancer esophageal adenocarcinoma malignant glioma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.