4LSD

Myokine structure

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Fibronectin type III	8088116	4007555	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Fibronectin type III	8088117	3002063	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Fibronectin type III	8088117	3002063	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Fibronectin type III	8088117	3002063	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Fibronectin type III	8088117	3002063	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Fibronectin type III	8088117	3002063	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Fibronectin type III	8088117	3002063	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Fibronectin type III	8088117	3002063	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Fibronectin type III	8088117	3002063	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00041	e4lsdA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF00041	ECOD (1.6)
B	PF00041	e4lsdB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF00041	ECOD (1.6)
C	PF00041	e4lsdC1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF00041	ECOD (1.6)
D	PF00041	e4lsdD1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF00041	ECOD (1.6)
E	PF00041	e4lsdE1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF00041	ECOD (1.6)
F	PF00041	e4lsdF1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF00041	ECOD (1.6)
G	PF00041	e4lsdG1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF00041	ECOD (1.6)
H	PF00041	e4lsdH1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF00041	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
B	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
C	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
D	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
E	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
F	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
G	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
H	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H	PF00041	Fibronectin type III domain (fn3)	Fibronectin type III domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H	Fibronectin type III domain-containing protein 5	hormone activity protein binding binding molecular function activator activity signaling receptor binding molecular function regulator activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity	response to stimulus response to activity response to muscle activity developmental process fat cell differentiation positive regulation of brown fat cell differentiation regulation of biological process regulation of cellular process positive regulation of fat cell differentiation cellular developmental process regulation of developmental process biological regulation positive regulation of biological process regulation of cell differentiation response to stimulus response to activity response to muscle activity developmental process fat cell differentiation positive regulation of brown fat cell differentiation regulation of biological process regulation of cellular process positive regulation of fat cell differentiation cellular developmental process regulation of developmental process biological regulation positive regulation of biological process regulation of cell differentiation regulation of brown fat cell differentiation positive regulation of developmental process positive regulation of cell differentiation brown fat cell differentiation cell differentiation cellular process regulation of fat cell differentiation positive regulation of cellular process	membrane-bounded organelle intracellular anatomical structure membrane peroxisome cellular anatomical entity intracellular membrane-bounded organelle microbody membrane intracellular organelle bounding membrane of organelle organelle peroxisomal membrane microbody cytoplasm organelle membrane membrane-bounded organelle intracellular anatomical structure membrane peroxisome cellular anatomical entity intracellular membrane-bounded organelle microbody membrane intracellular organelle bounding membrane of organelle organelle peroxisomal membrane microbody cytoplasm organelle membrane cell periphery plasma membrane extracellular region endoplasmic reticulum endomembrane system

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR003961	Fibronectin type III	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR036116	Fibronectin type III superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E A, B, C, D, E, F, G, H	Pharos: Q8NAU1	pilocytic astrocytoma psoriasis Ventricular Dysfunction, Left adrenal cortex carcinoma atypical teratoid rhabdoid tumor ductal breast carcinoma in situ glioblastoma lung carcinoma medulloblastoma oligodendroglioma pituitary cancer subependymal giant cell astrocytoma amyotrophic lateral sclerosis endomyocardial fibrosis inborn carbohydrate metabolic disorder pilocytic astrocytoma psoriasis Ventricular Dysfunction, Left adrenal cortex carcinoma atypical teratoid rhabdoid tumor ductal breast carcinoma in situ glioblastoma lung carcinoma medulloblastoma oligodendroglioma pituitary cancer subependymal giant cell astrocytoma amyotrophic lateral sclerosis endomyocardial fibrosis inborn carbohydrate metabolic disorder malignant ependymoma myopathy osteosarcoma primitive neuroectodermal tumor type 2 diabetes mellitus astrocytic tumor gastric carcinoma invasive ductal breast carcinoma malignant glioma obesity disorder

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.