4LQQ

Crystal structure of the Cbk1(T743E)-Mob2 kinase-coactivator complex in crystal form B

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00069	e4lqqA1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: PF00069	ECOD (1.6)
C [auth D]	PF00069	e4lqqD1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: PF00069	ECOD (1.6)
B	PF03637	e4lqqB1	A: alpha bundles	X: Bromodomain-like	H: Mob1/phocein (From Topology)	T: Mob1/phocein	F: PF03637	ECOD (1.6)
D [auth E]	PF03637	e4lqqE1	A: alpha bundles	X: Bromodomain-like	H: Mob1/phocein (From Topology)	T: Mob1/phocein	F: PF03637	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.200.20	Alpha Beta	2-Layer Sandwich	Phosphorylase Kinase	domain 1	CATH (4.3.0)
A	1.10.510.10	Mainly Alpha	Orthogonal Bundle	Transferase(Phosphotransferase)	domain 1	CATH (4.3.0)
C [auth D]	3.30.200.20	Alpha Beta	2-Layer Sandwich	Phosphorylase Kinase	domain 1	CATH (4.3.0)
C [auth D]	1.10.510.10	Mainly Alpha	Orthogonal Bundle	Transferase(Phosphotransferase)	domain 1	CATH (4.3.0)
B	1.20.140.30	Mainly Alpha	Up-down Bundle	Butyryl-CoA Dehydrogenase, subunit A	domain 3	CATH (4.3.0)
D [auth E]	1.20.140.30	Mainly Alpha	Up-down Bundle	Butyryl-CoA Dehydrogenase, subunit A	domain 3	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C [auth D]	PF00069	Protein kinase domain (Pkinase)	Protein kinase domain	-	Domain
B, D [auth E]	PF03637	Mob1/phocein family (Mob1_phocein)	Mob1/phocein family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C [auth D]	Serine/threonine-protein kinase CBK1	catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity protein serine kinase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity protein serine kinase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein serine/threonine kinase activity identical protein binding protein binding	cellular component organization establishment or maintenance of actin cytoskeleton polarity organelle organization establishment or maintenance of cytoskeleton polarity actin cytoskeleton organization actin filament-based process cellular process cellular component organization or biogenesis establishment or maintenance of cell polarity cytoskeleton organization protein localization regulation of localization establishment of protein localization cellular localization cellular component organization establishment or maintenance of actin cytoskeleton polarity organelle organization establishment or maintenance of cytoskeleton polarity actin cytoskeleton organization actin filament-based process cellular process cellular component organization or biogenesis establishment or maintenance of cell polarity cytoskeleton organization protein localization regulation of localization establishment of protein localization cellular localization nitrogen compound transport regulation of cellular process regulation of protein localization transport protein localization to extracellular region localization regulation of secretion by cell secretion by cell cellular macromolecule localization regulation of biological process regulation of transport secretion organic substance transport biological regulation regulation of establishment of protein localization establishment of protein localization to extracellular region export from cell regulation of protein transport protein secretion establishment of localization regulation of protein secretion regulation of secretion protein transport regulation of cellular localization macromolecule localization regulation of fungal-type cell wall organization fungal-type cell wall organization regulation of cellular component organization regulation of cell wall organization or biogenesis cell wall organization or biogenesis cell wall organization fungal-type cell wall organization or biogenesis external encapsulating structure organization reproductive process in single-celled organism reproductive process budding cell bud growth growth cell division budding cell apical bud growth cell budding asexual reproduction septum digestion after cytokinesis phosphorylation cellular metabolic process phosphate-containing compound metabolic process metabolic process phosphorus metabolic process cellular response to stimulus response to stimulus signaling signal transduction intracellular signal transduction cell communication	intracellular anatomical structure cytoplasmic ribonucleoprotein granule cellular anatomical entity ribonucleoprotein granule intracellular organelle organelle intracellular non-membrane-bounded organelle cytoplasm supramolecular complex non-membrane-bounded organelle cytoplasmic stress granule incipient cellular bud site site of polarized growth cellular bud intracellular anatomical structure cytoplasmic ribonucleoprotein granule cellular anatomical entity ribonucleoprotein granule intracellular organelle organelle intracellular non-membrane-bounded organelle cytoplasm supramolecular complex non-membrane-bounded organelle cytoplasmic stress granule incipient cellular bud site site of polarized growth cellular bud cellular bud tip cell periphery cell cortex cell projection mating projection cell tip mating projection tip cell pole plasma membrane bounded cell projection protein kinase complex transferase complex, transferring phosphorus-containing groups protein-containing complex catalytic complex serine/threonine protein kinase complex transferase complex ascospore-type prospore membrane prospore membrane intracellular immature spore cellular bud neck membrane-bounded organelle nucleus intracellular membrane-bounded organelle
B, D [auth E]	CBK1 kinase activator protein MOB2	enzyme regulator activity kinase activator activity enzyme activator activity molecular function activator activity molecular function regulator activity protein kinase activator activity protein kinase regulator activity kinase regulator activity	cellular process cell cycle establishment or maintenance of cell polarity cell division septum digestion after cytokinesis regulation of cellular process positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of phosphate metabolic process regulation of primary metabolic process cellular process cell cycle establishment or maintenance of cell polarity cell division septum digestion after cytokinesis regulation of cellular process positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of phosphate metabolic process regulation of primary metabolic process positive regulation of metabolic process positive regulation of protein modification process organic substance metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process positive regulation of macromolecule metabolic process protein metabolic process positive regulation of protein phosphorylation phosphorus metabolic process protein modification process positive regulation of cellular process regulation of biological process organonitrogen compound metabolic process protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation cellular metabolic process regulation of protein metabolic process biological regulation regulation of cellular metabolic process primary metabolic process regulation of macromolecule metabolic process macromolecule modification regulation of phosphorus metabolic process metabolic process regulation of phosphorylation macromolecule metabolic process regulation of metabolic process cellular response to stimulus response to stimulus signaling signal transduction cell communication reproductive process in single-celled organism reproductive process budding cell bud growth growth budding cell apical bud growth cell budding asexual reproduction	cellular bud cellular anatomical entity cellular bud tip site of polarized growth protein kinase complex transferase complex, transferring phosphorus-containing groups protein-containing complex catalytic complex serine/threonine protein kinase complex transferase complex cell projection mating projection cell tip mating projection tip cellular bud cellular anatomical entity cellular bud tip site of polarized growth protein kinase complex transferase complex, transferring phosphorus-containing groups protein-containing complex catalytic complex serine/threonine protein kinase complex transferase complex cell projection mating projection cell tip mating projection tip cell pole plasma membrane bounded cell projection cellular bud neck intracellular anatomical structure cytoplasm membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C [auth D]	IPR017441	Protein kinase, ATP binding site	Binding Site
A, C [auth D]	IPR000719	Protein kinase domain	Domain
A, C [auth D]	IPR000961	AGC-kinase, C-terminal	Domain
A, C [auth D]	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A, C [auth D]	IPR008271	Serine/threonine-protein kinase, active site	Active Site
B, D [auth E]	IPR036703	MOB kinase activator superfamily	Homologous Superfamily
B, D [auth E]	IPR005301	MOB kinase activator family	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.