4LLE

The crystal structure of R60L mutant of the histidine kinase (KinB) sensor domain from Pseudomonas aeruginosa PA01

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Histidine-containing phosphotransfer domain HPT domain	8091059	3001634	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Histidine-containing phosphotransfer domain HPT domain	8091059	3001634	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Histidine-containing phosphotransfer domain HPT domain	8091059	3001634	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Histidine-containing phosphotransfer domain HPT domain	8091059	3001634	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	KinB_sensor	e4lleA1	A: alpha bundles	X: STAT-like	H: t-snare proteins (From Topology)	T: t-snare proteins	F: KinB_sensor	ECOD (1.6)
B	KinB_sensor	e4lleB1	A: alpha bundles	X: STAT-like	H: t-snare proteins (From Topology)	T: t-snare proteins	F: KinB_sensor	ECOD (1.6)
C	KinB_sensor	e4lleC1	A: alpha bundles	X: STAT-like	H: t-snare proteins (From Topology)	T: t-snare proteins	F: KinB_sensor	ECOD (1.6)
D	KinB_sensor	e4lleD1	A: alpha bundles	X: STAT-like	H: t-snare proteins (From Topology)	T: t-snare proteins	F: KinB_sensor	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.120.880	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)	Histidine kinase (KinB), sensor domain	CATH (4.3.0)
B	1.20.120.880	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)	Histidine kinase (KinB), sensor domain	CATH (4.3.0)
C	1.20.120.880	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)	Histidine kinase (KinB), sensor domain	CATH (4.3.0)
D	1.20.120.880	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)	Histidine kinase (KinB), sensor domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF16767	Sensor domain of alginate biosynthesis sensor protein KinB (KinB_sensor)	Sensor domain of alginate biosynthesis sensor protein KinB	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Probable two-component sensor	catalytic activity, acting on a protein small molecule sensor activity kinase activity protein kinase activity transferase activity phosphotransferase activity, nitrogenous group as acceptor phosphotransferase activity, alcohol group as acceptor protein histidine kinase activity transferase activity, transferring phosphorus-containing groups phosphorelay sensor kinase activity catalytic activity phosphoric ester hydrolase activity hydrolase activity, acting on ester bonds phosphatase activity catalytic activity, acting on a protein small molecule sensor activity kinase activity protein kinase activity transferase activity phosphotransferase activity, nitrogenous group as acceptor phosphotransferase activity, alcohol group as acceptor protein histidine kinase activity transferase activity, transferring phosphorus-containing groups phosphorelay sensor kinase activity catalytic activity phosphoric ester hydrolase activity hydrolase activity, acting on ester bonds phosphatase activity hydrolase activity	-	membrane cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR000014	PAS domain	Domain
A, B, C, D	IPR038320	KinB, N-terminal domain superfamily	Homologous Superfamily
A, B, C, D	IPR004358	Signal transduction histidine kinase-related protein, C-terminal	Domain
A, B, C, D	IPR013656	PAS fold-4	Domain
A, B, C, D	IPR003594	Histidine kinase/HSP90-like ATPase	Domain
A, B, C, D	IPR036097	Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily	Homologous Superfamily
A, B, C, D	IPR003660	HAMP domain	Domain
A, B, C, D	IPR036890	Histidine kinase/HSP90-like ATPase superfamily	Homologous Superfamily
A, B, C, D	IPR003661	Signal transduction histidine kinase, dimerisation/phosphoacceptor domain	Domain
A, B, C, D	IPR035965	PAS domain superfamily	Homologous Superfamily
A, B, C, D	IPR031909	Alginate biosynthesis sensor protein KinB, sensor domain	Domain
A, B, C, D	IPR005467	Histidine kinase domain	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.