4LAC

Crystal Structure of Protein Phosphatase 2A (PP2A) and PP2A phosphatase activator (PTPA) complex with ATPgammaS

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A [auth B]	d4lacb_	All alpha proteins	PTPA-like	PTPA-like	PTPA-like	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d4lacc_	Alpha and beta proteins (a+b)	Metallo-dependent phosphatases	Metallo-dependent phosphatases	Protein serine/threonine phosphatase	Protein phosphatase 2A catalytic subunit alpha isoform, PP2A-alpha	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth B]	SCOP2B Superfamily	PTPA-like	8042445	3001997	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Metallo-dependent phosphatases	8039778	3001067	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth B]	PTPA	e4lacB1	A: alpha arrays	X: PTPA-like (From Topology)	H: PTPA-like (From Topology)	T: PTPA-like	F: PTPA	ECOD (1.6)
B [auth A]	CLASP_N_1	e4lacA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: CLASP_N_1	ECOD (1.6)
C	Metallophos_2_1	e4lacC1	A: a+b four layers	X: Carbon-nitrogen hydrolase-like	H: Metallo-dependent phosphatases (From Topology)	T: Metallo-dependent phosphatases	F: Metallophos_2_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth B]	1.20.120.1150	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)	Phosphotyrosyl phosphate activator, C-terminal lid domain	CATH (4.3.0)
B [auth A]	1.25.10.10	Mainly Alpha	Alpha Horseshoe	Leucine-rich Repeat Variant	Leucine-rich Repeat Variant	CATH (4.3.0)
C	3.60.21.10	Alpha Beta	4-Layer Sandwich	Purple Acid Phosphatase	chain A, domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth B]	PF03095	Phosphotyrosyl phosphate activator (PTPA) protein (PTPA)	Phosphotyrosyl phosphate activator (PTPA) protein	-	Family
B [auth A]	PF02985	HEAT repeat (HEAT)	HEAT repeat	-	Repeat
C	PF00149	Calcineurin-like phosphoesterase (Metallophos)	Calcineurin-like phosphoesterase	This family includes a diverse range of phosphoesterases [1], including protein phosphoserine phosphatases, nucleotidases, sphingomyelin phosphodiesterases and 2'-3' cAMP phosphodiesterases as well as nucleases such as bacterial SbcD Swiss:P13457 or ...	This family includes a diverse range of phosphoesterases [1], including protein phosphoserine phosphatases, nucleotidases, sphingomyelin phosphodiesterases and 2'-3' cAMP phosphodiesterases as well as nucleases such as bacterial SbcD Swiss:P13457 or yeast MRE11 Swiss:P32829. The most conserved regions in this superfamily centre around the metal chelating residues.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B]	Serine/threonine-protein phosphatase 2A activator	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein binding signaling receptor binding isomerase activity catalytic activity, acting on a protein peptidyl-prolyl cis-trans isomerase activity catalytic activity cis-trans isomerase activity protein phosphatase binding phosphatase binding enzyme binding protein phosphatase 2A binding identical protein binding protein homodimerization activity protein dimerization activity enzyme regulator activity phosphatase regulator activity molecular function regulator activity protein phosphatase regulator activity protein phosphatase activator activity enzyme activator activity protein tyrosine phosphatase activator activity phosphatase activator activity molecular function activator activity	protein dephosphorylation regulation of cellular process regulation of phosphatase activity regulation of catalytic activity negative regulation of biological process negative regulation of catalytic activity negative regulation of cellular metabolic process regulation of primary metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process negative regulation of protein modification process negative regulation of dephosphorylation phosphorus metabolic process protein modification process protein dephosphorylation regulation of cellular process regulation of phosphatase activity regulation of catalytic activity negative regulation of biological process negative regulation of catalytic activity negative regulation of cellular metabolic process regulation of primary metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process negative regulation of protein modification process negative regulation of dephosphorylation phosphorus metabolic process protein modification process negative regulation of protein metabolic process regulation of biological process regulation of dephosphorylation cellular metabolic process negative regulation of metabolic process dephosphorylation regulation of protein metabolic process regulation of cellular metabolic process primary metabolic process regulation of molecular function regulation of hydrolase activity macromolecule modification regulation of phosphorus metabolic process metabolic process macromolecule metabolic process regulation of metabolic process negative regulation of hydrolase activity negative regulation of phosphoprotein phosphatase activity negative regulation of protein dephosphorylation regulation of protein modification process negative regulation of phosphate metabolic process regulation of phosphoprotein phosphatase activity organic substance metabolic process negative regulation of phosphatase activity negative regulation of cellular process protein metabolic process negative regulation of macromolecule metabolic process organonitrogen compound metabolic process regulation of protein dephosphorylation biological regulation negative regulation of molecular function regulation of macromolecule metabolic process negative regulation of phosphorus metabolic process cellular process positive regulation of phosphoprotein phosphatase activity positive regulation of phosphate metabolic process positive regulation of metabolic process positive regulation of phosphatase activity positive regulation of macromolecule metabolic process positive regulation of phosphorus metabolic process positive regulation of dephosphorylation positive regulation of protein metabolic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of molecular function positive regulation of protein modification process positive regulation of cellular process positive regulation of catalytic activity positive regulation of protein dephosphorylation positive regulation of hydrolase activity microtubule cytoskeleton organization mitotic cell cycle mitotic spindle organization cellular component organization organelle organization mitotic cell cycle process microtubule-based process cell cycle cellular component organization or biogenesis cytoskeleton organization microtubule cytoskeleton organization involved in mitosis spindle organization cell cycle process positive regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death positive regulation of apoptotic process apoptotic process programmed cell death	ATPase complex protein-containing complex catalytic complex phosphatase complex protein phosphatase type 2A complex protein serine/threonine phosphatase complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity ATPase complex protein-containing complex catalytic complex phosphatase complex protein phosphatase type 2A complex protein serine/threonine phosphatase complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm transmembrane transporter complex membrane membrane protein complex cation channel complex transporter complex calcium channel complex monoatomic ion channel complex nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen nuclear lumen
B [auth A]	PP2A Scaffold Subunit A, Truncated, an internal deletion of PP2A A	protein antigen binding protein binding binding antigen binding enzyme regulator activity phosphatase regulator activity molecular function regulator activity protein phosphatase regulator activity phosphoric ester hydrolase activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds phosphatase activity protein antigen binding protein binding binding antigen binding enzyme regulator activity phosphatase regulator activity molecular function regulator activity protein phosphatase regulator activity phosphoric ester hydrolase activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds phosphatase activity hydrolase activity catalytic activity protein heterodimerization activity protein dimerization activity	cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis regulation of biological process cell adhesion regulation of cellular process regulation of cell adhesion biological regulation meiotic spindle elongation meiotic chromosome segregation cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis regulation of biological process cell adhesion regulation of cellular process regulation of cell adhesion biological regulation meiotic spindle elongation meiotic chromosome segregation sexual reproduction spindle elongation reproductive process microtubule cytoskeleton organization meiotic cell cycle process meiotic nuclear division cell cycle chromosome segregation spindle organization cell cycle process meiotic cell cycle organelle fission meiotic spindle organization organelle organization nuclear division nuclear chromosome segregation microtubule-based process cytoskeleton organization mitotic nuclear division chromosome organization sister chromatid segregation mitotic cell cycle mitotic cell cycle process chromosome separation mitotic sister chromatid segregation mitotic sister chromatid separation sister chromatid cohesion meiotic sister chromatid cohesion, centromeric centromeric sister chromatid cohesion meiotic sister chromatid cohesion response to organic substance response to stimulus response to chemical cellular response to stimulus positive regulation of cell communication positive regulation of signal transduction signal transduction in absence of ligand signaling positive regulation of biological process regulation of signal transduction regulation of programmed cell death positive regulation of extrinsic apoptotic signaling pathway in absence of ligand extrinsic apoptotic signaling pathway cell communication positive regulation of apoptotic signaling pathway positive regulation of response to stimulus extrinsic apoptotic signaling pathway in absence of ligand signal transduction positive regulation of cellular process regulation of signaling positive regulation of programmed cell death cell surface receptor signaling pathway regulation of apoptotic process positive regulation of extrinsic apoptotic signaling pathway cell death positive regulation of apoptotic process regulation of extrinsic apoptotic signaling pathway apoptotic signaling pathway regulation of response to stimulus regulation of extrinsic apoptotic signaling pathway in absence of ligand regulation of cell communication apoptotic process programmed cell death regulation of apoptotic signaling pathway positive regulation of signaling protein dephosphorylation organonitrogen compound metabolic process dephosphorylation cellular metabolic process primary metabolic process organic substance metabolic process macromolecule modification phosphate-containing compound metabolic process metabolic process protein metabolic process macromolecule metabolic process protein modification process phosphorus metabolic process DNA metabolic process regulation of macromolecule metabolic process nucleic acid metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication regulation of nucleobase-containing compound metabolic process regulation of metabolic process regulation of DNA replication regulation of DNA metabolic process regulation of growth growth multicellular organismal process multicellular organismal-level homeostasis leukocyte homeostasis T cell homeostasis homeostatic process immune system process homeostasis of number of cells lymphocyte homeostasis multicellular organismal reproductive process female gamete generation gamete generation female meiotic nuclear division regulation of cellular component organization negative regulation of biological process negative regulation of cell growth regulation of cell growth cell growth negative regulation of growth negative regulation of cellular process RNA splicing cellular biosynthetic process RNA metabolic process gene expression macromolecule biosynthetic process biosynthetic process organic substance biosynthetic process RNA processing negative regulation of signaling negative regulation of intracellular signal transduction intracellular signal transduction negative regulation of cell communication regulation of intracellular signal transduction intracellular signaling cassette negative regulation of response to stimulus regulation of MAPK cascade negative regulation of signal transduction MAPK cascade negative regulation of MAPK cascade negative regulation of cellular metabolic process regulation of phosphate metabolic process peptidyl-amino acid modification negative regulation of protein modification process regulation of receptor signaling pathway via JAK-STAT negative regulation of protein metabolic process tyrosine phosphorylation of STAT protein negative regulation of receptor signaling pathway via JAK-STAT protein phosphorylation phosphorylation regulation of protein metabolic process negative regulation of metabolic process regulation of cellular metabolic process negative regulation of protein phosphorylation regulation of phosphorus metabolic process regulation of receptor signaling pathway via STAT cell surface receptor signaling pathway via STAT regulation of protein modification process regulation of protein phosphorylation negative regulation of phosphate metabolic process peptidyl-tyrosine modification negative regulation of macromolecule metabolic process negative regulation of peptidyl-tyrosine phosphorylation regulation of tyrosine phosphorylation of STAT protein regulation of peptidyl-tyrosine phosphorylation negative regulation of tyrosine phosphorylation of STAT protein negative regulation of phosphorus metabolic process regulation of phosphorylation negative regulation of phosphorylation peptidyl-tyrosine phosphorylation negative regulation of receptor signaling pathway via STAT cell surface receptor signaling pathway via JAK-STAT RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process nucleobase-containing compound biosynthetic process regulation of cellular biosynthetic process regulation of gene expression organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of Wnt signaling pathway Wnt signaling pathway regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction meiotic cell cycle process involved in oocyte maturation cellular developmental process regulation of reproductive process cell development cellular process involved in reproduction in multicellular organism developmental process involved in reproduction oocyte development cell differentiation anatomical structure development cell maturation regulation of cell cycle developmental process regulation of cell cycle process oogenesis regulation of meiotic cell cycle process involved in oocyte maturation developmental maturation anatomical structure maturation germ cell development oocyte maturation oocyte differentiation ceramide metabolic process membrane lipid metabolic process sphingolipid metabolic process cellular lipid metabolic process amide metabolic process lipid metabolic process regulation of developmental process regulation of cell differentiation	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle phosphatase complex protein-containing complex catalytic complex protein phosphatase type 2A complex protein serine/threonine phosphatase complex membrane membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle phosphatase complex protein-containing complex catalytic complex protein phosphatase type 2A complex protein serine/threonine phosphatase complex membrane extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytosol intracellular non-membrane-bounded organelle chromosome, centromeric region chromosome chromosomal region non-membrane-bounded organelle somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection synapse cell junction glutamatergic synapse cytoskeleton microtubule cytoskeleton cell body neuronal cell body cell periphery plasma membrane lateral plasma membrane nucleus
C	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	phosphoric ester hydrolase activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds phosphatase activity hydrolase activity catalytic activity myosin phosphatase activity cytoskeletal protein binding protein binding binding tau protein binding cation binding phosphoric ester hydrolase activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds phosphatase activity hydrolase activity catalytic activity myosin phosphatase activity cytoskeletal protein binding protein binding binding tau protein binding cation binding ion binding metal ion binding small molecule binding protein heterodimerization activity protein dimerization activity signaling receptor binding GABA receptor binding protein tyrosine phosphatase activity	regulation of biological process cell adhesion regulation of cellular process regulation of cell adhesion biological regulation cellular process response to organic substance response to stimulus response to chemical developmental process anatomical structure development tissue development mesoderm development protein dephosphorylation regulation of biological process cell adhesion regulation of cellular process regulation of cell adhesion biological regulation cellular process response to organic substance response to stimulus response to chemical developmental process anatomical structure development tissue development mesoderm development protein dephosphorylation organonitrogen compound metabolic process dephosphorylation cellular metabolic process primary metabolic process organic substance metabolic process macromolecule modification phosphate-containing compound metabolic process metabolic process protein metabolic process macromolecule metabolic process protein modification process phosphorus metabolic process DNA metabolic process regulation of macromolecule metabolic process nucleic acid metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication regulation of nucleobase-containing compound metabolic process regulation of metabolic process regulation of DNA replication regulation of DNA metabolic process regulation of growth growth apoptotic process cell death programmed cell death regulation of protein binding regulation of molecular function regulation of binding regulation of microtubule binding regulation of cellular component organization negative regulation of biological process negative regulation of cell growth regulation of cell growth cell growth cellular component organization negative regulation of growth negative regulation of cellular process cellular component organization or biogenesis RNA splicing cellular biosynthetic process RNA metabolic process gene expression macromolecule biosynthetic process biosynthetic process organic substance biosynthetic process RNA processing RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of cellular metabolic process nucleobase-containing compound biosynthetic process regulation of cellular biosynthetic process regulation of gene expression organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription cellular response to stimulus regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction signaling negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction regulation of signal transduction intracellular signal transduction negative regulation of cell communication cell communication regulation of intracellular signal transduction intracellular signaling cassette signal transduction regulation of signaling negative regulation of response to stimulus negative regulation of signal transduction regulation of response to stimulus regulation of cell communication phosphatidylinositol 3-kinase/protein kinase B signal transduction regulation of epithelial to mesenchymal transition multicellular organismal process regulation of developmental process cellular developmental process regulation of cell differentiation mesenchyme development cell differentiation negative regulation of cell differentiation regulation of multicellular organismal process negative regulation of developmental process animal organ development negative regulation of epithelial to mesenchymal transition epithelial to mesenchymal transition mesenchymal cell differentiation negative regulation of multicellular organismal process peptidyl-serine dephosphorylation positive regulation of phosphorylation regulation of catalytic activity regulation of transferase activity positive regulation of phosphate metabolic process positive regulation of protein serine/threonine kinase activity positive regulation of metabolic process regulation of phosphate metabolic process positive regulation of macromolecule metabolic process positive regulation of protein phosphorylation protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process positive regulation of kinase activity regulation of kinase activity regulation of protein serine/threonine kinase activity regulation of phosphorus metabolic process regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of molecular function positive regulation of protein modification process positive regulation of protein kinase activity positive regulation of cellular process positive regulation of transferase activity positive regulation of catalytic activity regulation of protein kinase activity regulation of phosphorylation positive regulation of protein binding positive regulation of microtubule binding positive regulation of binding ceramide metabolic process membrane lipid metabolic process sphingolipid metabolic process cellular lipid metabolic process amide metabolic process lipid metabolic process cell cycle mitotic cell cycle multicellular organismal-level homeostasis leukocyte homeostasis T cell homeostasis homeostatic process immune system process homeostasis of number of cells lymphocyte homeostasis negative regulation of cellular metabolic process peptidyl-amino acid modification negative regulation of protein modification process regulation of receptor signaling pathway via JAK-STAT negative regulation of protein metabolic process tyrosine phosphorylation of STAT protein negative regulation of receptor signaling pathway via JAK-STAT negative regulation of metabolic process negative regulation of protein phosphorylation regulation of receptor signaling pathway via STAT cell surface receptor signaling pathway via STAT negative regulation of phosphate metabolic process peptidyl-tyrosine modification negative regulation of macromolecule metabolic process negative regulation of peptidyl-tyrosine phosphorylation cell surface receptor signaling pathway regulation of tyrosine phosphorylation of STAT protein regulation of peptidyl-tyrosine phosphorylation negative regulation of tyrosine phosphorylation of STAT protein negative regulation of phosphorus metabolic process negative regulation of phosphorylation peptidyl-tyrosine phosphorylation negative regulation of receptor signaling pathway via STAT cell surface receptor signaling pathway via JAK-STAT positive regulation of cell communication positive regulation of response to biotic stimulus positive regulation of signal transduction pattern recognition receptor signaling pathway regulation of NLRP3 inflammasome complex assembly positive regulation of NLRP3 inflammasome complex assembly response to biotic stimulus cellular component biogenesis immune response-activating signaling pathway cellular component assembly inflammasome-mediated signaling pathway positive regulation of immune response canonical inflammasome complex assembly regulation of immune system process positive regulation of immune system process innate immune response-activating signaling pathway positive regulation of pattern recognition receptor signaling pathway immune response response to other organism regulation of innate immune response response to external stimulus positive regulation of inflammasome-mediated signaling pathway regulation of inflammasome-mediated signaling pathway defense response to other organism regulation of pattern recognition receptor signaling pathway NLRP3 inflammasome complex assembly positive regulation of defense response activation of innate immune response regulation of immune response inflammatory response activation of immune response cytoplasmic pattern recognition receptor signaling pathway regulation of defense response regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms positive regulation of cellular component organization regulation of response to external stimulus intracellular receptor signaling pathway regulation of cytoplasmic pattern recognition receptor signaling pathway positive regulation of response to stimulus regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly positive regulation of response to external stimulus immune response-regulating signaling pathway regulation of response to stress response to stress innate immune response protein-containing complex assembly response to external biotic stimulus positive regulation of innate immune response defense response protein-containing complex organization positive regulation of cellular component biogenesis defense response to symbiont regulation of cellular component biogenesis positive regulation of signaling regulation of Wnt signaling pathway Wnt signaling pathway response to metal ion response to lead ion response to inorganic substance pyridine nucleotide catabolic process oxoacid metabolic process carbohydrate catabolic process organophosphate catabolic process carbohydrate derivative metabolic process regulation of generation of precursor metabolites and energy nucleoside phosphate catabolic process organic acid metabolic process regulation of ATP metabolic process regulation of purine nucleotide catabolic process negative regulation of nucleotide metabolic process regulation of small molecule metabolic process regulation of nucleotide metabolic process small molecule metabolic process purine ribonucleotide catabolic process negative regulation of carbohydrate metabolic process nucleoside phosphate metabolic process organonitrogen compound catabolic process pyruvate metabolic process negative regulation of purine nucleotide catabolic process purine nucleoside diphosphate metabolic process purine-containing compound catabolic process regulation of purine nucleotide metabolic process nucleobase-containing compound catabolic process nucleoside diphosphate metabolic process monocarboxylic acid metabolic process pyridine-containing compound catabolic process ribose phosphate metabolic process ATP metabolic process negative regulation of purine nucleotide metabolic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process negative regulation of nucleotide catabolic process purine nucleotide catabolic process carbohydrate derivative catabolic process regulation of glycolytic process through fructose-6-phosphate organic cyclic compound catabolic process purine-containing compound metabolic process ADP metabolic process purine ribonucleoside diphosphate metabolic process organic substance catabolic process purine ribonucleoside diphosphate catabolic process negative regulation of glycolytic process through fructose-6-phosphate ribonucleotide catabolic process negative regulation of small molecule metabolic process negative regulation of glycolytic process negative regulation of ATP metabolic process glycolytic process pyridine-containing compound metabolic process negative regulation of nucleobase-containing compound metabolic process pyridine nucleotide metabolic process nicotinamide nucleotide metabolic process regulation of carbohydrate catabolic process nucleotide metabolic process purine nucleoside diphosphate catabolic process nucleoside diphosphate catabolic process regulation of nucleotide catabolic process nucleoside triphosphate metabolic process purine ribonucleotide metabolic process catabolic process purine nucleotide metabolic process ribonucleotide metabolic process ribonucleoside diphosphate metabolic process ribonucleoside diphosphate catabolic process regulation of carbohydrate metabolic process nucleotide catabolic process ribonucleoside triphosphate metabolic process negative regulation of catabolic process purine nucleoside triphosphate metabolic process carbohydrate metabolic process ADP catabolic process carboxylic acid metabolic process regulation of catabolic process generation of precursor metabolites and energy regulation of glycolytic process organophosphate metabolic process glycolytic process through fructose-6-phosphate regulation of cell cycle phase transition regulation of cell cycle process cell cycle phase transition regulation of cell cycle G1/S phase transition cell cycle G1/S phase transition regulation of mitotic cell cycle phase transition regulation of mitotic cell cycle regulation of G1/S transition of mitotic cell cycle mitotic cell cycle process regulation of cell cycle G1/S transition of mitotic cell cycle cell cycle process mitotic cell cycle phase transition sexual reproduction reproductive process meiotic cell cycle peptidyl-threonine dephosphorylation	intracellular organelle intracellular anatomical structure cytoskeleton spindle organelle intracellular non-membrane-bounded organelle spindle pole cellular anatomical entity microtubule cytoskeleton non-membrane-bounded organelle membrane extracellular exosome membrane-bounded organelle extracellular vesicle intracellular organelle intracellular anatomical structure cytoskeleton spindle organelle intracellular non-membrane-bounded organelle spindle pole cellular anatomical entity microtubule cytoskeleton non-membrane-bounded organelle membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytoplasm cytosol mitochondrion intracellular membrane-bounded organelle phosphatase complex protein-containing complex catalytic complex protein phosphatase type 2A complex protein serine/threonine phosphatase complex cell periphery plasma membrane chromosome, centromeric region chromosome chromosomal region membrane microdomain membrane raft synapse cell junction nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B]	IPR004327	Phosphotyrosyl phosphatase activator, PTPA	Family
A [auth B]	IPR043170	Phosphotyrosyl phosphatase activator, C-terminal lid domain	Homologous Superfamily
A [auth B]	IPR037218	PTPA superfamily	Homologous Superfamily
B [auth A]	IPR016024	Armadillo-type fold	Homologous Superfamily
B [auth A]	IPR021133	HEAT, type 2	Repeat
B [auth A]	IPR011989	Armadillo-like helical	Homologous Superfamily
B [auth A]	IPR000357	HEAT repeat	Repeat
C	IPR047129	Serine/Threonine protein phosphatase PP2A-like	Family
C	IPR004843	Calcineurin-like phosphoesterase domain, ApaH type	Domain
C	IPR029052	Metallo-dependent phosphatase-like	Homologous Superfamily
C	IPR006186	Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth B]	Pharos: Q15257	bipolar disorder gastric cancer major affective disorder 2 medulloblastoma Disease Exacerbation gastric neoplasm malignant ependymoma sleep-wake disorder hereditary diffuse gastric adenocarcinoma
B [auth A]	Pharos: P30153	microcephaly-corpus callosum hypoplasia-intellectual disability-facial dysmorphism syndrome intellectual disability Disease Exacerbation gastric neoplasm osteoarthritis hereditary diffuse gastric adenocarcinoma osteoarthritis susceptibility 1 rheumatoid arthritis gastric cancer
C	Pharos: P67775	asthma heart disease systemic lupus erythematosus adenoma astrocytic tumor coronary artery disease hereditary spastic paraplegia lymphoplasmacytic lymphoma osteosarcoma psoriasis tuberculosis allergic rhinitis atypical teratoid rhabdoid tumor glioblastoma large cell medulloblastoma asthma heart disease systemic lupus erythematosus adenoma astrocytic tumor coronary artery disease hereditary spastic paraplegia lymphoplasmacytic lymphoma osteosarcoma psoriasis tuberculosis allergic rhinitis atypical teratoid rhabdoid tumor glioblastoma large cell medulloblastoma malignant glioma ovarian cancer subependymal giant cell astrocytoma breast cancer lung adenocarcinoma myocardial ischemia plasma cell myeloma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.