4L0R

Crystal structure of FGF2-interacting protein from Homo sapiens. Northeast Structural Genomics Consortium Target HR9027A.

External Resource: Annotation

Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.58.90	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
B	1.20.58.90	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF06657	Centrosome microtubule-binding domain of Cep57 (Cep57_MT_bd)	Centrosome microtubule-binding domain of Cep57	This C-terminal region of Cep57 binds, nucleates and bundles microtubules. The N-terminal part, family Cep57_CLD, Pfam:PF14073, is the centrosome localisation domain Cep57 [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Centrosomal protein of 57 kDa	fibroblast growth factor binding protein binding binding growth factor binding cytoskeletal protein binding gamma-tubulin binding tubulin binding microtubule binding identical protein binding protein homodimerization activity protein dimerization activity	developmental process spermatid development spermatid differentiation sexual reproduction cellular developmental process spermatogenesis reproductive process multicellular organismal reproductive process cell development cellular process involved in reproduction in multicellular organism developmental process involved in reproduction gamete generation male gamete generation cell differentiation anatomical structure development developmental process spermatid development spermatid differentiation sexual reproduction cellular developmental process spermatogenesis reproductive process multicellular organismal reproductive process cell development cellular process involved in reproduction in multicellular organism developmental process involved in reproduction gamete generation male gamete generation cell differentiation anatomical structure development germ cell development cellular process response to fibroblast growth factor cellular response to stimulus regulation of biological process cellular response to growth factor stimulus regulation of cellular process response to stimulus cell surface receptor signaling pathway signaling response to endogenous stimulus biological regulation cell surface receptor protein tyrosine kinase signaling pathway cell communication cellular response to endogenous stimulus fibroblast growth factor receptor signaling pathway response to growth factor signal transduction cellular response to fibroblast growth factor stimulus enzyme-linked receptor protein signaling pathway cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein complex oligomerization protein-containing complex assembly protein homooligomerization cellular component organization or biogenesis	membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle endomembrane system centrosome microtubule organizing center cytoskeleton intracellular non-membrane-bounded organelle microtubule cytoskeleton membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle endomembrane system centrosome microtubule organizing center cytoskeleton intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle centriolar satellite cytosol polymeric cytoskeletal fiber supramolecular fiber microtubule supramolecular polymer supramolecular complex nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR025913	Cep57 centrosome localisation domain	Domain
A, B	IPR024957	Cep57 centrosome microtubule-binding domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q86XR8	mosaic variegated aneuploidy syndrome mosaic variegated aneuploidy syndrome 2 mosaic variegated aneuploidy syndrome 1 Warburton Anyane Yeboa syndrome allergic rhinitis intellectual disability lymphoplasmacytic lymphoma malignant mesothelioma ovarian cancer psoriasis atypical teratoid rhabdoid tumor large cell medulloblastoma malignant ependymoma medulloblastoma primitive neuroectodermal tumor mosaic variegated aneuploidy syndrome mosaic variegated aneuploidy syndrome 2 mosaic variegated aneuploidy syndrome 1 Warburton Anyane Yeboa syndrome allergic rhinitis intellectual disability lymphoplasmacytic lymphoma malignant mesothelioma ovarian cancer psoriasis atypical teratoid rhabdoid tumor large cell medulloblastoma malignant ependymoma medulloblastoma primitive neuroectodermal tumor tuberculosis lung cancer malignant glioma osteosarcoma progressive supranuclear palsy

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.