4KWF

Crystal Structure Analysis of ALDH2+ALDiB33

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4kwfa_	Alpha and beta proteins (a/b)	ALDH-like	ALDH-like	ALDH-like	Aldehyde reductase (dehydrogenase), ALDH	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d4kwfb_	Alpha and beta proteins (a/b)	ALDH-like	ALDH-like	ALDH-like	Aldehyde reductase (dehydrogenase), ALDH	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d4kwfc_	Alpha and beta proteins (a/b)	ALDH-like	ALDH-like	ALDH-like	Aldehyde reductase (dehydrogenase), ALDH	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d4kwfd_	Alpha and beta proteins (a/b)	ALDH-like	ALDH-like	ALDH-like	Aldehyde reductase (dehydrogenase), ALDH	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E	d4kwfe_	Alpha and beta proteins (a/b)	ALDH-like	ALDH-like	ALDH-like	Aldehyde reductase (dehydrogenase), ALDH	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F	d4kwff_	Alpha and beta proteins (a/b)	ALDH-like	ALDH-like	ALDH-like	Aldehyde reductase (dehydrogenase), ALDH	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
G	d4kwfg_	Alpha and beta proteins (a/b)	ALDH-like	ALDH-like	ALDH-like	Aldehyde reductase (dehydrogenase), ALDH	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
H	d4kwfh_	Alpha and beta proteins (a/b)	ALDH-like	ALDH-like	ALDH-like	Aldehyde reductase (dehydrogenase), ALDH	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	ALDH-like	8033787	3001479	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	ALDH-like	8033787	3001479	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	ALDH-like	8033787	3001479	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	ALDH-like	8033787	3001479	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	ALDH-like	8033787	3001479	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	ALDH-like	8033787	3001479	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	ALDH-like	8033787	3001479	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	ALDH-like	8033787	3001479	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00171	e4kwfA2	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: PF00171	ECOD (1.6)
B	PF00171	e4kwfB2	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: PF00171	ECOD (1.6)
C	PF00171	e4kwfC1	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: PF00171	ECOD (1.6)
D	PF00171	e4kwfD1	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: PF00171	ECOD (1.6)
E	PF00171	e4kwfE2	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: PF00171	ECOD (1.6)
F	PF00171	e4kwfF2	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: PF00171	ECOD (1.6)
G	PF00171	e4kwfG2	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: PF00171	ECOD (1.6)
H	PF00171	e4kwfH1	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: PF00171	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.605.10	Alpha Beta	3-Layer(aba) Sandwich	Aldehyde Dehydrogenase	Chain A, domain 1	CATH (4.3.0)
A	3.40.309.10	Alpha Beta	3-Layer(aba) Sandwich	Aldehyde Dehydrogenase	Chain A, domain 2	CATH (4.3.0)
B	3.40.605.10	Alpha Beta	3-Layer(aba) Sandwich	Aldehyde Dehydrogenase	Chain A, domain 1	CATH (4.3.0)
B	3.40.309.10	Alpha Beta	3-Layer(aba) Sandwich	Aldehyde Dehydrogenase	Chain A, domain 2	CATH (4.3.0)
C	3.40.605.10	Alpha Beta	3-Layer(aba) Sandwich	Aldehyde Dehydrogenase	Chain A, domain 1	CATH (4.3.0)
C	3.40.309.10	Alpha Beta	3-Layer(aba) Sandwich	Aldehyde Dehydrogenase	Chain A, domain 2	CATH (4.3.0)
D	3.40.605.10	Alpha Beta	3-Layer(aba) Sandwich	Aldehyde Dehydrogenase	Chain A, domain 1	CATH (4.3.0)
D	3.40.309.10	Alpha Beta	3-Layer(aba) Sandwich	Aldehyde Dehydrogenase	Chain A, domain 2	CATH (4.3.0)
E	3.40.605.10	Alpha Beta	3-Layer(aba) Sandwich	Aldehyde Dehydrogenase	Chain A, domain 1	CATH (4.3.0)
E	3.40.309.10	Alpha Beta	3-Layer(aba) Sandwich	Aldehyde Dehydrogenase	Chain A, domain 2	CATH (4.3.0)
F	3.40.605.10	Alpha Beta	3-Layer(aba) Sandwich	Aldehyde Dehydrogenase	Chain A, domain 1	CATH (4.3.0)
F	3.40.309.10	Alpha Beta	3-Layer(aba) Sandwich	Aldehyde Dehydrogenase	Chain A, domain 2	CATH (4.3.0)
G	3.40.605.10	Alpha Beta	3-Layer(aba) Sandwich	Aldehyde Dehydrogenase	Chain A, domain 1	CATH (4.3.0)
G	3.40.309.10	Alpha Beta	3-Layer(aba) Sandwich	Aldehyde Dehydrogenase	Chain A, domain 2	CATH (4.3.0)
H	3.40.605.10	Alpha Beta	3-Layer(aba) Sandwich	Aldehyde Dehydrogenase	Chain A, domain 1	CATH (4.3.0)
H	3.40.309.10	Alpha Beta	3-Layer(aba) Sandwich	Aldehyde Dehydrogenase	Chain A, domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H	PF00171	Aldehyde dehydrogenase family (Aldedh)	Aldehyde dehydrogenase family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H	Aldehyde dehydrogenase, mitochondrial	oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors catalytic activity aldehyde dehydrogenase [NAD(P)+] activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor aldehyde dehydrogenase (NAD+) activity phenylacetaldehyde dehydrogenase activity hydrolase activity, acting on ester bonds carboxylesterase activity carboxylic ester hydrolase activity hydrolase activity nitroglycerin reductase activity oxidoreductase activity, acting on other nitrogenous compounds as donors oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors catalytic activity aldehyde dehydrogenase [NAD(P)+] activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor aldehyde dehydrogenase (NAD+) activity phenylacetaldehyde dehydrogenase activity hydrolase activity, acting on ester bonds carboxylesterase activity carboxylic ester hydrolase activity hydrolase activity nitroglycerin reductase activity oxidoreductase activity, acting on other nitrogenous compounds as donors oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity NAD binding binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding adenyl nucleotide binding nucleotide binding heterocyclic compound binding small molecule binding electron transfer activity	organic hydroxy compound metabolic process organonitrogen compound biosynthetic process dopamine metabolic process catechol-containing compound metabolic process regulation of primary metabolic process biogenic amine biosynthetic process organic substance metabolic process catecholamine metabolic process dopamine biosynthetic process catecholamine biosynthetic process organic substance biosynthetic process catechol-containing compound biosynthetic process regulation of dopamine metabolic process regulation of biosynthetic process organic hydroxy compound metabolic process organonitrogen compound biosynthetic process dopamine metabolic process catechol-containing compound metabolic process regulation of primary metabolic process biogenic amine biosynthetic process organic substance metabolic process catecholamine metabolic process dopamine biosynthetic process catecholamine biosynthetic process organic substance biosynthetic process catechol-containing compound biosynthetic process regulation of dopamine metabolic process regulation of biosynthetic process regulation of biological process organonitrogen compound metabolic process regulation of amine metabolic process biological regulation primary metabolic process regulation of dopamine biosynthetic process organic cyclic compound metabolic process amine metabolic process biosynthetic process amine biosynthetic process phenol-containing compound metabolic process organic hydroxy compound biosynthetic process organic cyclic compound biosynthetic process phenol-containing compound biosynthetic process metabolic process regulation of catecholamine metabolic process regulation of metabolic process biogenic amine metabolic process carbohydrate metabolic process cellular catabolic process catabolic process cellular aldehyde metabolic process cellular metabolic process cellular process aldehyde catabolic process organic substance catabolic process alcohol catabolic process primary alcohol catabolic process alcohol metabolic process ethanol metabolic process organic hydroxy compound catabolic process ethanol catabolic process small molecule metabolic process small molecule catabolic process primary alcohol metabolic process serotonin metabolic process indole-containing compound metabolic process primary amino compound metabolic process ammonium ion metabolic process indole-containing compound biosynthetic process serotonin biosynthetic process primary amino compound biosynthetic process regulation of serotonin biosynthetic process	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle membrane-enclosed lumen mitochondrial matrix intracellular organelle lumen organelle lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H	IPR015590	Aldehyde dehydrogenase domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR016161	Aldehyde/histidinol dehydrogenase	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR016162	Aldehyde dehydrogenase, N-terminal	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR029510	Aldehyde dehydrogenase, glutamic acid active site	Conserved Site
A, B, C, D, E A, B, C, D, E, F, G, H	IPR016163	Aldehyde dehydrogenase, C-terminal	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR016160	Aldehyde dehydrogenase, cysteine active site	Conserved Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E A, B, C, D, E, F, G, H	Pharos: P05091	alcohol abuse esophageal squamous cell carcinoma vascular disease alcohol sensitivity, acute occupational dermatitis Liver Cirrhosis, Experimental male infertility colorectal cancer psoriasis asthma esophageal cancer perinatal necrotizing enterocolitis alcohol-induced disorders neoplasm of esophagus pancreatic intraductal papillary-mucinous neoplasm alcohol abuse esophageal squamous cell carcinoma vascular disease alcohol sensitivity, acute occupational dermatitis Liver Cirrhosis, Experimental male infertility colorectal cancer psoriasis asthma esophageal cancer perinatal necrotizing enterocolitis alcohol-induced disorders neoplasm of esophagus pancreatic intraductal papillary-mucinous neoplasm gout pituitary cancer heart disease primitive neuroectodermal tumor age-related macular degeneration invasive ductal breast carcinoma wet macular degeneration alcohol-related disorders B-cell chronic lymphocytic leukemia medulloblastoma breast fibroadenoma myocardial infarction non-alcoholic fatty liver disease ovarian cancer ductal breast carcinoma in situ pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia precancerous condition large cell medulloblastoma lung adenocarcinoma bipolar disorder carcinoma of esophagus necrotizing enterocolitis colorectal carcinoma non-small cell lung carcinoma pancreatic ductal adenocarcinoma glioblastoma alcohol dependence inherited disease susceptibility Wernicke-Korsakoff syndrome limb-girdle muscular dystrophy lung cancer atypical teratoid rhabdoid tumor malignant glioma breast carcinoma metabolic syndrome X chronic obstructive pulmonary disease

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.