Annotations: 4KSO

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A [auth C]	d4ksoc_	Alpha and beta proteins (a/b)	Thioredoxin fold	Thioredoxin-like	KaiB-like	Circadian oscillation regulator KaiB	(Synechococcus elongatus PCC 7942 = FACHB-805 ) [TaxId: 1140 ],	SCOPe (2.08)
B [auth D]	d4ksod_	Alpha and beta proteins (a/b)	Thioredoxin fold	Thioredoxin-like	KaiB-like	Circadian oscillation regulator KaiB	(Synechococcus elongatus PCC 7942 = FACHB-805 ) [TaxId: 1140 ],	SCOPe (2.08)
C [auth A]	d4ksoa_	Alpha and beta proteins (a/b)	Thioredoxin fold	Thioredoxin-like	KaiB-like	Circadian oscillation regulator KaiB	(Synechococcus elongatus PCC 7942 = FACHB-805 ) [TaxId: 1140 ],	SCOPe (2.08)
D [auth B]	d4ksob_	Alpha and beta proteins (a/b)	Thioredoxin fold	Thioredoxin-like	KaiB-like	Circadian oscillation regulator KaiB	(Synechococcus elongatus PCC 7942 = FACHB-805 ) [TaxId: 1140 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth C]	SCOP2B Superfamily	Thioredoxin-like	8084495	3000031	SCOP2B (2022-06-29)
B [auth D]	SCOP2B Superfamily	Thioredoxin-like	8084495	3000031	SCOP2B (2022-06-29)
C [auth A]	SCOP2 Family	KaiB-like	8084494	4001101	SCOP2 (2022-06-29)
C [auth A]	SCOP2 Superfamily	Thioredoxin-like	8084495	3000031	SCOP2 (2022-06-29)
D [auth B]	SCOP2B Superfamily	Thioredoxin-like	8084495	3000031	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth C]	KaiB	e4ksoC1	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: KaiB	ECOD (1.6)
B [auth D]	KaiB	e4ksoD1	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: KaiB	ECOD (1.6)
C [auth A]	KaiB	e4ksoA1	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: KaiB	ECOD (1.6)
D [auth B]	KaiB	e4ksoB1	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: KaiB	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth C]	3.40.30.10	Alpha Beta	3-Layer(aba) Sandwich	Glutaredoxin	Glutaredoxin	CATH (4.3.0)
B [auth D]	3.40.30.10	Alpha Beta	3-Layer(aba) Sandwich	Glutaredoxin	Glutaredoxin	CATH (4.3.0)
C [auth A]	3.40.30.10	Alpha Beta	3-Layer(aba) Sandwich	Glutaredoxin	Glutaredoxin	CATH (4.3.0)
D [auth B]	3.40.30.10	Alpha Beta	3-Layer(aba) Sandwich	Glutaredoxin	Glutaredoxin	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth C], B [auth D], C [auth A], D [auth B]	PF07689	KaiB domain (KaiB)	KaiB domain	The cyanobacterial clock proteins KaiA and KaiB are proposed as regulators of the circadian rhythm in cyanobacteria. Mutations in both proteins have been reported to alter or abolish circadian rhythmicity. KaiB adopts an alpha-beta meander motif and ...	The cyanobacterial clock proteins KaiA and KaiB are proposed as regulators of the circadian rhythm in cyanobacteria. Mutations in both proteins have been reported to alter or abolish circadian rhythmicity. KaiB adopts an alpha-beta meander motif and is found to be a dimer [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth C], B [auth D], C [auth A], D [auth B]	Circadian clock protein KaiB	identical protein binding protein binding binding	regulation of biological process regulation of cellular process phosphorylation cellular metabolic process negative regulation of metabolic process biological regulation negative regulation of biological process negative regulation of phosphate metabolic process regulation of cellular metabolic process negative regulation of cellular metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process negative regulation of phosphorus metabolic process negative regulation of cellular process regulation of biological process regulation of cellular process phosphorylation cellular metabolic process negative regulation of metabolic process biological regulation negative regulation of biological process negative regulation of phosphate metabolic process regulation of cellular metabolic process negative regulation of cellular metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process negative regulation of phosphorus metabolic process negative regulation of cellular process regulation of phosphorus metabolic process metabolic process cellular process regulation of phosphorylation negative regulation of phosphorylation phosphorus metabolic process regulation of metabolic process rhythmic process circadian rhythm entrainment of circadian clock response to stimulus response to external stimulus regulation of circadian rhythm	cell periphery plasma membrane membrane cellular anatomical entity intracellular anatomical structure cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth C], B [auth D], C [auth A], D [auth B]	IPR039022	Circadian clock protein KaiB-like	Family
A [auth C], B [auth D], C [auth A], D [auth B]	IPR036249	Thioredoxin-like superfamily	Homologous Superfamily
A [auth C], B [auth D], C [auth A], D [auth B]	IPR011649	KaiB domain	Domain
A [auth C], B [auth D], C [auth A], D [auth B]	IPR013474	Circadian clock protein KaiB	Family

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.