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The X-ray crystal structure of Mannose-binding lectin-associated serine proteinase-3 reveals the structural basis for enzyme inactivity associated with the 3MC syndrome External Resource: Annotation Chains Family Name Domain Identifier Architecture Possible Homology Homology Topology Family Provenance Source (Version) A PF00089 e4kkdA6 A: beta barrels X: cradle loop barrel H: RIFT-related T: FMN-binding split barrel 2 F: PF00089 ECOD (1.6) A PF00084 e4kkdA3 A: few secondary structure elements X: EGF-like H: EGF-related T: Complement control module/SCR domain F: PF00084 ECOD (1.6) B PF00089 e4kkdB1 A: beta barrels X: cradle loop barrel H: RIFT-related T: FMN-binding split barrel 2 F: PF00089 ECOD (1.6) B PF00084 e4kkdB2 A: few secondary structure elements X: EGF-like H: EGF-related T: Complement control module/SCR domain F: PF00084 ECOD (1.6)
Chains Polymer Molecular Function Biological Process Cellular Component Mannan-binding lectin serine protease 1
Chains Accession Name Type IPR018097 EGF-like calcium-binding, conserved site Conserved Site IPR035914 Spermadhesin, CUB domain superfamily Homologous Superfamily IPR000436 Sushi/SCR/CCP domain Domain IPR000859 CUB domain Domain IPR000742 EGF-like domain Domain IPR018114 Serine proteases, trypsin family, histidine active site Active Site IPR035976 Sushi/SCR/CCP superfamily Homologous Superfamily IPR009003 Peptidase S1, PA clan Homologous Superfamily IPR001314 Peptidase S1A, chymotrypsin family Family IPR033116 Serine proteases, trypsin family, serine active site Active Site IPR001254 Serine proteases, trypsin domain Domain IPR001881 EGF-like calcium-binding domain Domain IPR043504 Peptidase S1, PA clan, chymotrypsin-like fold Homologous Superfamily IPR024175 Peptidase S1A, complement C1r/C1S/mannan-binding Family
Chains Drug Target   Associated Disease Pharos :  P48740