4KHB

Structure of the Spt16D Pob3N heterodimer

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
F [auth E]	SCOP2B Superfamily	PH domain-like	8103649	3000134	SCOP2B (2022-06-29)
A	SCOP2 Family	SPT16-like	8051087	4007194	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	PH domain-like	8103649	3000134	SCOP2 (2022-06-29)
E [auth G]	SCOP2B Superfamily	PH domain-like	8103649	3000134	SCOP2B (2022-06-29)
G [auth C]	SCOP2B Superfamily	PH domain-like	8103649	3000134	SCOP2B (2022-06-29)
B [auth D]	SCOP2B Superfamily	PH domain-like	8103648	3000134	SCOP2B (2022-06-29)
B [auth D]	SCOP2B Superfamily	PH domain-like	8103647	3000134	SCOP2B (2022-06-29)
C [auth F]	SCOP2 Family	POB3 N-terminal domain-like	8046816	4005313	SCOP2 (2022-06-29)
C [auth F]	SCOP2 Family	SSRP1-like	8051653	4007454	SCOP2 (2022-06-29)
C [auth F]	SCOP2 Superfamily	PH domain-like	8103647	3000134	SCOP2 (2022-06-29)
C [auth F]	SCOP2 Superfamily	PH domain-like	8103648	3000134	SCOP2 (2022-06-29)
D [auth H]	SCOP2B Superfamily	PH domain-like	8103648	3000134	SCOP2B (2022-06-29)
D [auth H]	SCOP2B Superfamily	PH domain-like	8103647	3000134	SCOP2B (2022-06-29)
H [auth B]	SCOP2B Superfamily	PH domain-like	8103647	3000134	SCOP2B (2022-06-29)
H [auth B]	SCOP2B Superfamily	PH domain-like	8103648	3000134	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
F [auth E]	PF08644	e4khbE2	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: PF08644	ECOD (1.6)
A	PF08644	e4khbA1	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: PF08644	ECOD (1.6)
E [auth G]	PF08644	e4khbG2	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: PF08644	ECOD (1.6)
G [auth C]	PF08644	e4khbC2	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: PF08644	ECOD (1.6)
B [auth D]	PF03531	e4khbD2	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: PF03531	ECOD (1.6)
B [auth D]	PF17292	e4khbD1	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: PF17292	ECOD (1.6)
C [auth F]	PF03531	e4khbF2	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: PF03531	ECOD (1.6)
C [auth F]	PF17292	e4khbF1	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: PF17292	ECOD (1.6)
D [auth H]	PF03531	e4khbH2	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: PF03531	ECOD (1.6)
D [auth H]	PF17292	e4khbH1	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: PF17292	ECOD (1.6)
H [auth B]	PF03531	e4khbB2	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: PF03531	ECOD (1.6)
H [auth B]	PF17292	e4khbB1	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: PF17292	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
F [auth E]	2.30.29.210	Mainly Beta	Roll	PH-domain like	FACT complex subunit Spt16p/Cdc68p	CATH (4.3.0)
A	2.30.29.210	Mainly Beta	Roll	PH-domain like	FACT complex subunit Spt16p/Cdc68p	CATH (4.3.0)
E [auth G]	2.30.29.210	Mainly Beta	Roll	PH-domain like	FACT complex subunit Spt16p/Cdc68p	CATH (4.3.0)
G [auth C]	2.30.29.210	Mainly Beta	Roll	PH-domain like	FACT complex subunit Spt16p/Cdc68p	CATH (4.3.0)
B [auth D]	2.30.29.30	Mainly Beta	Roll	PH-domain like	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	CATH (4.3.0)
B [auth D]	2.30.29.220	Mainly Beta	Roll	PH-domain like	Structure-specific recognition protein (SSRP1)	CATH (4.3.0)
C [auth F]	2.30.29.30	Mainly Beta	Roll	PH-domain like	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	CATH (4.3.0)
C [auth F]	2.30.29.220	Mainly Beta	Roll	PH-domain like	Structure-specific recognition protein (SSRP1)	CATH (4.3.0)
D [auth H]	2.30.29.30	Mainly Beta	Roll	PH-domain like	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	CATH (4.3.0)
D [auth H]	2.30.29.220	Mainly Beta	Roll	PH-domain like	Structure-specific recognition protein (SSRP1)	CATH (4.3.0)
H [auth B]	2.30.29.30	Mainly Beta	Roll	PH-domain like	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	CATH (4.3.0)
H [auth B]	2.30.29.220	Mainly Beta	Roll	PH-domain like	Structure-specific recognition protein (SSRP1)	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, E [auth G], F [auth E], G [auth C]	PF08644	FACT complex subunit (SPT16/CDC68) (SPT16)	FACT complex subunit (SPT16/CDC68)	Proteins in this family are subunits the FACT complex. The FACT complex plays a role in transcription initiation and promotes binding of TATA-binding protein (TBP) to a TATA box in chromatin [2].	Domain
B [auth D], C [auth F], D [auth H], H [auth B]	PF03531	Structure-specific recognition protein (SSRP1) (SSrecog)	Structure-specific recognition protein (SSRP1)	SSRP1 has been implicated in transcriptional initiation and elongation and in DNA replication and repair [1]. This domain belongs to the Pleckstrin homology fold superfamily.	Domain
B [auth D], C [auth F], D [auth H], H [auth B]	PF17292	POB3-like N-terminal PH domain (POB3_N)	POB3-like N-terminal PH domain	This domain is found at the N-terminus of POB3 and related proteins.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, E [auth G], F [auth E], G [auth C]	Uncharacterized protein SPT16D	cation binding ion binding binding metal ion binding small molecule binding	nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process cellular response to stimulus response to stimulus cellular response to stress DNA damage response response to stress nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process cellular response to stimulus response to stimulus cellular response to stress DNA damage response response to stress cellular process DNA repair	membrane-bounded organelle protein-containing complex intracellular anatomical structure transcription elongation factor complex protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex chromatin chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle membrane-bounded organelle protein-containing complex intracellular anatomical structure transcription elongation factor complex protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex chromatin chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle FACT complex nucleoplasm organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle
B [auth D], C [auth F], D [auth H], H [auth B]	Uncharacterized protein POB3N	DNA binding binding organic cyclic compound binding nucleic acid binding	nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process cellular response to stimulus response to stimulus cellular response to stress DNA damage response response to stress nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process cellular response to stimulus response to stimulus cellular response to stress DNA damage response response to stress cellular process DNA repair	intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle chromosome cellular anatomical entity non-membrane-bounded organelle membrane-bounded organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, E [auth G], F [auth E], G [auth C]	IPR033825	FACT complex subunit Spt16, peptidase M24-like domain	Domain
A, E [auth G], F [auth E], G [auth C]	IPR048969	FACT complex subunit SPT16, C-terminal domain	Domain
A, E [auth G], F [auth E], G [auth C]	IPR029149	Creatinase/Aminopeptidase P/Spt16, N-terminal	Homologous Superfamily
A, E [auth G], F [auth E], G [auth C]	IPR011993	PH-like domain superfamily	Homologous Superfamily
A, E [auth G], F [auth E], G [auth C]	IPR013719	Histone chaperone RTT106/FACT complex subunit SPT16-like, middle domain	Domain
A, E [auth G], F [auth E], G [auth C]	IPR040258	FACT complex subunit Spt16	Family
A, E [auth G], F [auth E], G [auth C]	IPR029148	FACT complex subunit Spt16, N-terminal lobe domain	Domain
A, E [auth G], F [auth E], G [auth C]	IPR013953	FACT complex subunit Spt16 domain	Domain
A, E [auth G], F [auth E], G [auth C]	IPR036005	Creatinase/aminopeptidase-like	Homologous Superfamily
A, E [auth G], F [auth E], G [auth C]	IPR000994	Peptidase M24	Domain
B [auth D], C [auth F], D [auth H], H [auth B]	IPR038167	SSRP1 domain superfamily	Homologous Superfamily
B [auth D], C [auth F], D [auth H], H [auth B]	IPR011993	PH-like domain superfamily	Homologous Superfamily
B [auth D], C [auth F], D [auth H], H [auth B]	IPR013719	Histone chaperone RTT106/FACT complex subunit SPT16-like, middle domain	Domain
B [auth D], C [auth F], D [auth H], H [auth B]	IPR048993	FACT complex subunit SSRP1-like, first PH domain	Domain
B [auth D], C [auth F], D [auth H], H [auth B]	IPR035417	FACT complex subunit SSRP1/POB3, N-terminal PH domain	Domain
B [auth D], C [auth F], D [auth H], H [auth B]	IPR024954	SSRP1, dimerization domain	Domain
B [auth D], C [auth F], D [auth H], H [auth B]	IPR000969	FACT complex subunit SSRP1/POB3	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.