Annotations: 4K6J

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF07814	e4k6jA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF07814	ECOD (1.6)
B	PF07814	e4k6jB2	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF07814	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.25.10.10	Mainly Alpha	Alpha Horseshoe	Leucine-rich Repeat Variant	Leucine-rich Repeat Variant	CATH (4.3.0)
B	1.25.10.10	Mainly Alpha	Alpha Horseshoe	Leucine-rich Repeat Variant	Leucine-rich Repeat Variant	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF07814	Wings apart-like protein regulation of heterochromatin (WAPL)	Wings apart-like protein regulation of heterochromatin	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Wings apart-like protein homolog	ATP-dependent activity, acting on DNA catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid ATP-dependent protein-DNA unloader activity catalytic activity ATP-dependent activity	cellular process cell division negative regulation of chromatin binding regulation of molecular function regulation of binding negative regulation of binding biological regulation negative regulation of molecular function regulation of chromatin binding protein localization localization protein localization to chromatin cellular localization protein localization to chromosome cellular process cell division negative regulation of chromatin binding regulation of molecular function regulation of binding negative regulation of binding biological regulation negative regulation of molecular function regulation of chromatin binding protein localization localization protein localization to chromatin cellular localization protein localization to chromosome protein localization to organelle cellular macromolecule localization macromolecule localization regulation of localization regulation of cellular component organization regulation of cellular process regulation of protein localization cellular component organization cohesin loading cellular component organization or biogenesis cell cycle regulation of protein localization to chromatin regulation of cell cycle cell cycle process regulation of cohesin loading regulation of biological process regulation of cell cycle process chromosome organization sister chromatid cohesion regulation of chromosome organization regulation of organelle organization organelle organization regulation of cellular localization regulation of sister chromatid cohesion establishment of sister chromatid cohesion mitotic nuclear division organelle fission sister chromatid segregation mitotic cell cycle nuclear division mitotic cell cycle process mitotic sister chromatid segregation nuclear chromosome segregation chromosome segregation negative regulation of biological process regulation of primary metabolic process nucleobase-containing compound metabolic process organic substance metabolic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process negative regulation of DNA replication negative regulation of metabolic process primary metabolic process regulation of macromolecule metabolic process DNA metabolic process nucleic acid metabolic process organic cyclic compound metabolic process DNA replication negative regulation of DNA metabolic process metabolic process macromolecule metabolic process regulation of metabolic process regulation of DNA metabolic process regulation of DNA replication negative regulation of cell cycle negative regulation of sister chromatid cohesion negative regulation of chromosome organization negative regulation of cellular process negative regulation of cellular component organization negative regulation of cell cycle process negative regulation of organelle organization	intercellular bridge cellular anatomical entity intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle chromosome non-membrane-bounded organelle cytoplasm cytosol membrane-bounded organelle intracellular membrane-bounded organelle chromosome, centromeric region chromosomal region intercellular bridge cellular anatomical entity intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle chromosome non-membrane-bounded organelle cytoplasm cytosol membrane-bounded organelle intracellular membrane-bounded organelle chromosome, centromeric region chromosomal region mitotic spindle cytoskeleton spindle microtubule cytoskeleton nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen protein-containing complex protein-DNA complex chromatin

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR039874	Wings apart-like protein	Family
A, B	IPR016024	Armadillo-type fold	Homologous Superfamily
A, B	IPR011989	Armadillo-like helical	Homologous Superfamily
A, B	IPR022771	Wings apart-like protein, C-terminal	Domain
A, B	IPR012502	WAPL domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q7Z5K2	breast cancer malignant mesothelioma psoriasis large cell medulloblastoma myopathy lymphoplasmacytic lymphoma ovarian cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.