4K34

Crystal structures of CusC review conformational changes accompanying folding and transmembrane channel formation

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4k34a1	Membrane and cell surface proteins and peptides	Outer membrane efflux proteins (OEP)	Outer membrane efflux proteins (OEP)	automated matches	automated matches	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)
A	d4k34a2	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)
B	d4k34b_	Membrane and cell surface proteins and peptides	Outer membrane efflux proteins (OEP)	Outer membrane efflux proteins (OEP)	automated matches	automated matches	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Outer membrane efflux proteins (OEP)	8085541	3000246	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Outer membrane efflux proteins (OEP)	8085541	3000246	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF02321	e4k34A1	A: a+b duplicates or obligate multimers	X: Outer membrane efflux proteins (OEP) (From Topology)	H: Outer membrane efflux proteins (OEP) (From Topology)	T: Outer membrane efflux proteins (OEP)	F: PF02321	ECOD (1.6)
B	PF02321	e4k34B1	A: a+b duplicates or obligate multimers	X: Outer membrane efflux proteins (OEP) (From Topology)	H: Outer membrane efflux proteins (OEP) (From Topology)	T: Outer membrane efflux proteins (OEP)	F: PF02321	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.1600.10	Mainly Alpha	Up-down Bundle	Outer membrane efflux proteins (OEP)	Outer membrane efflux proteins (OEP)	CATH (4.3.0)
B	1.20.1600.10	Mainly Alpha	Up-down Bundle	Outer membrane efflux proteins (OEP)	Outer membrane efflux proteins (OEP)	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF02321	Outer membrane efflux protein (OEP)	Outer membrane efflux protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Cation efflux system protein CusC	monoatomic cation transmembrane transporter activity inorganic molecular entity transmembrane transporter activity copper ion transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transition metal ion transmembrane transporter activity metal ion transmembrane transporter activity transmembrane transporter activity wide pore channel activity passive transmembrane transporter activity channel activity porin activity binding monoatomic cation transmembrane transporter activity inorganic molecular entity transmembrane transporter activity copper ion transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transition metal ion transmembrane transporter activity metal ion transmembrane transporter activity transmembrane transporter activity wide pore channel activity passive transmembrane transporter activity channel activity porin activity binding lipid binding diacylglycerol binding cation binding transition metal ion binding copper ion binding ion binding metal ion binding small molecule binding efflux transmembrane transporter activity identical protein binding protein binding	response to stimulus response to metal ion response to chemical response to silver ion response to inorganic substance response to copper ion transport monoatomic ion transmembrane transport inorganic ion transmembrane transport silver ion transport establishment of localization metal ion transport inorganic cation transmembrane transport transmembrane transport response to stimulus response to metal ion response to chemical response to silver ion response to inorganic substance response to copper ion transport monoatomic ion transmembrane transport inorganic ion transmembrane transport silver ion transport establishment of localization metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization silver ion transmembrane transport transition metal ion transport monoatomic ion transport cellular process monoatomic cation transport detoxification of inorganic compound detoxification of copper ion detoxification stress response to copper ion response to toxic substance response to stress stress response to metal ion organonitrogen compound metabolic process cellular biosynthetic process lipoprotein biosynthetic process cellular metabolic process lipoprotein metabolic process organonitrogen compound biosynthetic process primary metabolic process macromolecule biosynthetic process protein acylation protein lipidation organic substance metabolic process protein palmitoylation biosynthetic process macromolecule modification organic substance biosynthetic process metabolic process protein metabolic process macromolecule metabolic process protein modification process inorganic ion homeostasis homeostatic process intracellular copper ion homeostasis copper ion homeostasis cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis copper ion transmembrane transport copper ion transport copper ion export protein-containing complex organization protein trimerization cellular component organization cellular component biogenesis cellular component assembly protein homotrimerization protein complex oligomerization protein-containing complex assembly protein homooligomerization cellular component organization or biogenesis	membrane cellular anatomical entity protein-containing complex pore complex membrane protein complex cell periphery cell outer membrane external encapsulating structure cell envelope outer membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR010131	RND efflux system, outer membrane lipoprotein, NodT	Family
A, B	IPR003423	Outer membrane efflux protein	Family

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B	mpstruc	TRANSMEMBRANE PROTEINS: BETA-BARREL	Beta-Barrel Membrane Proteins: Monomeric/Dimeric	CusC heavy metal discharge outer membrane protein

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.