Annotations: 4K0V

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8053442	3000071	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8053441	3000071	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	EGF/Laminin-like	8053444	3000412	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	EGF/Laminin-like	8053443	3000412	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8053440	3000071	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Fibrinogen C-terminal domain-like	8070778	3001395	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e4k0vA3	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: F_UNCLASSIFIED	ECOD (1.6)
A	PF00041	e4k0vA7	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF00041	ECOD (1.6)
A	PF10430	e4k0vA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF10430	ECOD (1.6)
A	F_UNCLASSIFIED	e4k0vA4	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: EGF/Laminin	F: F_UNCLASSIFIED	ECOD (1.6)
A	PF07974	e4k0vA5	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: EGF/Laminin	F: PF07974	ECOD (1.6)
B	PF00147	e4k0vB1	A: a+b complex topology	X: Fibrinogen C-terminal domain-like (From Topology)	H: Fibrinogen C-terminal domain-like (From Topology)	T: Fibrinogen C-terminal domain-like	F: PF00147	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF10430	Tie-2 Ig-like domain 1 (Ig_Tie2_1)	Tie-2 Ig-like domain 1	-	Domain
A	PF00041	Fibronectin type III domain (fn3)	Fibronectin type III domain	-	Domain
B	PF00147	Fibrinogen beta and gamma chains, C-terminal globular domain (Fibrinogen_C)	Fibrinogen beta and gamma chains, C-terminal globular domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	TEK tyrosine kinase variant	molecular transducer activity catalytic activity, acting on a protein kinase activity protein kinase activity signaling receptor activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity transmembrane receptor protein kinase activity transmembrane signaling receptor activity catalytic activity binding molecular transducer activity catalytic activity, acting on a protein kinase activity protein kinase activity signaling receptor activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity transmembrane receptor protein kinase activity transmembrane signaling receptor activity catalytic activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding identical protein binding protein binding growth factor binding	developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development circulatory system development system development cell adhesion substrate adhesion-dependent cell spreading cell-substrate adhesion cellular process renal system development vasculature development developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development circulatory system development system development cell adhesion substrate adhesion-dependent cell spreading cell-substrate adhesion cellular process renal system development vasculature development kidney vasculature development glomerulus development renal system vasculature development glomerulus vasculature development nephron development kidney development blood vessel development regulation of vascular permeability system process circulatory system process biological regulation vascular process in circulatory system regulation of biological quality blood circulation regulation of biological process signaling cell-cell signaling cell communication endochondral ossification replacement ossification endochondral bone morphogenesis anatomical structure morphogenesis skeletal system development ossification skeletal system morphogenesis animal organ morphogenesis bone morphogenesis bone development cellular response to stimulus regulation of cellular process cell surface receptor signaling pathway response to stimulus Tie signaling pathway cell surface receptor protein tyrosine kinase signaling pathway signal transduction enzyme-linked receptor protein signaling pathway blood vessel morphogenesis tube development angiogenesis sprouting angiogenesis tube morphogenesis anatomical structure formation involved in morphogenesis regulation of cellular component organization positive regulation of cellular component organization cell-substrate junction assembly positive regulation of cell-substrate junction organization positive regulation of biological process cellular component organization cellular component biogenesis cellular component assembly cell junction assembly positive regulation of cell-substrate adhesion regulation of cell-substrate junction organization cellular component organization or biogenesis positive regulation of cellular process focal adhesion assembly positive regulation of focal adhesion assembly positive regulation of cellular component biogenesis regulation of cell-substrate adhesion positive regulation of cell adhesion regulation of cell adhesion positive regulation of cell-matrix adhesion regulation of cellular component biogenesis regulation of cell junction assembly positive regulation of cell junction assembly cell junction organization cell-matrix adhesion regulation of cell-matrix adhesion cell-substrate junction organization regulation of focal adhesion assembly regulation of cell-substrate junction assembly positive regulation of cell communication regulation of signaling positive regulation of signal transduction positive regulation of intracellular signal transduction regulation of signal transduction intracellular signal transduction positive regulation of response to stimulus regulation of intracellular signal transduction regulation of response to stimulus regulation of cell communication positive regulation of signaling response to decreased oxygen levels response to hypoxia response to stress response to oxygen levels response to abiotic stimulus phosphorylation cellular metabolic process phosphate-containing compound metabolic process metabolic process phosphorus metabolic process definitive hemopoiesis cellular developmental process hemopoiesis cell differentiation cell development response to organic substance response to chemical response to organonitrogen compound response to organophosphorus response to oxygen-containing compound response to nitrogen compound response to purine-containing compound response to cAMP response to organic cyclic compound small GTPase-mediated signal transduction regulation of small GTPase mediated signal transduction intracellular signaling cassette Rac protein signal transduction regulation of Rac protein signal transduction positive regulation of Rac protein signal transduction positive regulation of small GTPase mediated signal transduction cell population proliferation endothelial cell proliferation epithelial cell proliferation regulation of epithelial cell apoptotic process regulation of apoptotic process regulation of programmed cell death cell death epithelial cell apoptotic process endothelial cell apoptotic process apoptotic process programmed cell death regulation of endothelial cell apoptotic process response to hormone response to endogenous stimulus response to peptide hormone positive regulation of locomotion regulation of cell motility endothelial cell migration positive regulation of cell migration positive regulation of epithelial cell migration tissue migration ameboidal-type cell migration positive regulation of cell motility regulation of cell migration regulation of endothelial cell migration cell migration regulation of multicellular organismal process epithelial cell migration cell motility regulation of epithelial cell migration locomotion epithelium migration regulation of locomotion positive regulation of endothelial cell migration response to estrogen positive regulation of ERK1 and ERK2 cascade positive regulation of MAPK cascade regulation of MAPK cascade MAPK cascade ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade negative regulation of programmed cell death negative regulation of biological process negative regulation of apoptotic process negative regulation of cellular process regulation of establishment or maintenance of cell polarity establishment or maintenance of cell polarity regulation of defense response regulation of response to external stimulus negative regulation of inflammatory response defense response negative regulation of response to stimulus response to external stimulus regulation of inflammatory response negative regulation of response to external stimulus regulation of response to stress negative regulation of defense response inflammatory response Rho protein signal transduction regulation of Rho protein signal transduction positive regulation of Rho protein signal transduction regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction cardiac chamber morphogenesis heart trabecula formation heart morphogenesis cardiac chamber development heart trabecula morphogenesis trabecula formation trabecula morphogenesis regulation of developmental process regulation of vasculature development positive regulation of developmental process regulation of anatomical structure morphogenesis regulation of multicellular organismal development positive regulation of angiogenesis positive regulation of vasculature development regulation of angiogenesis positive regulation of multicellular organismal process positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of cellular metabolic process positive regulation of phosphate metabolic process regulation of primary metabolic process positive regulation of metabolic process positive regulation of protein modification process organic substance metabolic process regulation of phosphate metabolic process positive regulation of macromolecule metabolic process protein metabolic process positive regulation of protein phosphorylation protein modification process organonitrogen compound metabolic process protein phosphorylation positive regulation of phosphorus metabolic process regulation of protein metabolic process regulation of cellular metabolic process primary metabolic process regulation of macromolecule metabolic process macromolecule modification regulation of phosphorus metabolic process regulation of phosphorylation macromolecule metabolic process regulation of metabolic process negative regulation of blood vessel morphogenesis negative regulation of developmental process negative regulation of angiogenesis negative regulation of vasculature development negative regulation of multicellular organismal process negative regulation of endothelial cell apoptotic process negative regulation of epithelial cell apoptotic process positive regulation of cell population proliferation positive regulation of epithelial cell proliferation regulation of endothelial cell proliferation regulation of cell population proliferation positive regulation of endothelial cell proliferation regulation of epithelial cell proliferation	cell-cell junction anchoring junction cell junction cellular anatomical entity cell periphery basal part of cell membrane plasma membrane basal plasma membrane plasma membrane region basolateral plasma membrane intracellular anatomical structure cytoplasm protein-containing complex cell-cell junction anchoring junction cell junction cellular anatomical entity cell periphery basal part of cell membrane plasma membrane basal plasma membrane plasma membrane region basolateral plasma membrane intracellular anatomical structure cytoplasm protein-containing complex receptor complex cell projection actin-based cell projection microvillus plasma membrane bounded cell projection focal adhesion cell-substrate junction apical part of cell apical plasma membrane intracellular organelle centrosome microtubule organizing center cytoskeleton centriolar satellite organelle intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle cell surface membrane microdomain membrane raft extracellular region
B	Angiopoietin-1	protein tyrosine kinase binding protein binding binding kinase binding signaling receptor binding receptor tyrosine kinase binding enzyme binding protein kinase binding identical protein binding	protein localization negative regulation of protein transport regulation of localization establishment of protein localization negative regulation of nucleocytoplasmic transport nitrogen compound transport regulation of cellular process nucleocytoplasmic transport nuclear transport negative regulation of biological process negative regulation of intracellular protein transport negative regulation of transport localization import into nucleus cellular macromolecule localization protein localization negative regulation of protein transport regulation of localization establishment of protein localization negative regulation of nucleocytoplasmic transport nitrogen compound transport regulation of cellular process nucleocytoplasmic transport nuclear transport negative regulation of biological process negative regulation of intracellular protein transport negative regulation of transport localization import into nucleus cellular macromolecule localization establishment of localization in cell regulation of intracellular transport regulation of biological process organic substance transport negative regulation of establishment of protein localization intracellular transport regulation of nucleocytoplasmic transport protein localization to nucleus establishment of localization establishment of protein localization to organelle regulation of intracellular protein transport intracellular protein transport cellular localization regulation of protein localization transport regulation of protein localization to nucleus negative regulation of protein import into nucleus regulation of protein import into nucleus protein import into nucleus negative regulation of cellular process negative regulation of protein localization negative regulation of intracellular transport regulation of transport biological regulation regulation of establishment of protein localization regulation of protein transport negative regulation of protein localization to nucleus protein transport regulation of cellular localization macromolecule localization protein localization to organelle cellular process carbohydrate derivative biosynthetic process mucopolysaccharide metabolic process organonitrogen compound metabolic process heparin metabolic process cellular biosynthetic process cellular metabolic process glycosaminoglycan metabolic process organonitrogen compound biosynthetic process carbohydrate derivative metabolic process heparin biosynthetic process macromolecule biosynthetic process sulfur compound biosynthetic process organic substance metabolic process biosynthetic process aminoglycan metabolic process organic substance biosynthetic process aminoglycan biosynthetic process sulfur compound metabolic process metabolic process glycosaminoglycan biosynthetic process macromolecule metabolic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of biosynthetic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression regulation of cellular biosynthetic process regulation of gene expression positive regulation of gene expression regulation of macromolecule biosynthetic process regulation of metabolic process positive regulation of cellular biosynthetic process developmental process multicellular organismal process animal organ development renal system development vasculature development kidney vasculature development circulatory system development glomerulus development multicellular organism development renal system vasculature development anatomical structure development glomerulus vasculature development nephron development kidney development system development blood vessel development regulation of protein modification process regulation of protein phosphorylation negative regulation of phosphate metabolic process negative regulation of cellular metabolic process regulation of primary metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process negative regulation of protein modification process protein metabolic process protein modification process phosphorus metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process protein phosphorylation phosphorylation regulation of protein metabolic process negative regulation of metabolic process primary metabolic process negative regulation of protein phosphorylation macromolecule modification negative regulation of phosphorus metabolic process regulation of phosphorylation regulation of phosphorus metabolic process negative regulation of phosphorylation positive chemotaxis chemotaxis response to stimulus taxis response to chemical response to external stimulus locomotion positive regulation of phosphorylation positive regulation of protein metabolic process regulation of peptidyl-serine phosphorylation positive regulation of phosphate metabolic process peptidyl-serine modification positive regulation of protein modification process peptidyl-serine phosphorylation peptidyl-amino acid modification positive regulation of protein phosphorylation positive regulation of phosphorus metabolic process positive regulation of peptidyl-serine phosphorylation cellular developmental process hemopoiesis cell differentiation cell development regulation of immune effector process cytokine production regulation of immune system process negative regulation of cytokine production involved in immune response regulation of cytokine production involved in immune response immune response negative regulation of immune effector process negative regulation of cellular biosynthetic process immune effector process negative regulation of production of molecular mediator of immune response negative regulation of gene expression negative regulation of macromolecule biosynthetic process regulation of production of molecular mediator of immune response negative regulation of multicellular organismal process regulation of cytokine production regulation of multicellular organismal process cytokine production involved in immune response production of molecular mediator of immune response negative regulation of cytokine production negative regulation of immune system process negative regulation of biosynthetic process immune system process cellular response to stimulus cell surface receptor signaling pathway signaling Tie signaling pathway cell surface receptor protein tyrosine kinase signaling pathway cell communication signal transduction enzyme-linked receptor protein signaling pathway blood vessel morphogenesis tube development angiogenesis sprouting angiogenesis anatomical structure morphogenesis tube morphogenesis anatomical structure formation involved in morphogenesis negative regulation of vascular permeability regulation of vascular permeability system process circulatory system process vascular process in circulatory system regulation of biological quality blood circulation embryo development ending in birth or egg hatching chordate embryonic development embryo development in utero embryonic development regulation of catalytic activity regulation of transferase activity cellular component biogenesis cellular component assembly activation of transmembrane receptor protein tyrosine kinase activity regulation of molecular function positive regulation of kinase activity regulation of kinase activity activation of protein kinase activity cellular component organization positive regulation of molecular function protein-containing complex assembly cellular component organization or biogenesis positive regulation of protein kinase activity positive regulation of transferase activity protein-containing complex organization positive regulation of catalytic activity regulation of protein kinase activity cell adhesion regulation of cell adhesion negative regulation of cell adhesion positive regulation of locomotion regulation of cell motility endothelial cell migration positive regulation of cell migration positive regulation of epithelial cell migration tissue migration ameboidal-type cell migration positive regulation of cell motility regulation of cell migration regulation of endothelial cell migration cell migration epithelial cell migration cell motility regulation of epithelial cell migration epithelium migration regulation of locomotion positive regulation of endothelial cell migration positive regulation of cell communication positive regulation of signal transduction regulation of signal transduction intracellular signal transduction positive regulation of response to stimulus positive regulation of ERK1 and ERK2 cascade regulation of intracellular signal transduction intracellular signaling cassette regulation of signaling positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade regulation of response to stimulus MAPK cascade regulation of cell communication ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade positive regulation of signaling negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death negative regulation of apoptotic process apoptotic process programmed cell death protein localization to cell surface import into cell regulation of cellular component organization positive regulation of cellular component organization receptor internalization regulation of receptor internalization vesicle-mediated transport positive regulation of endocytosis positive regulation of receptor-mediated endocytosis regulation of endocytosis regulation of receptor-mediated endocytosis regulation of vesicle-mediated transport positive regulation of receptor internalization positive regulation of transport endocytosis receptor-mediated endocytosis regulation of protein ubiquitination positive regulation of post-translational protein modification protein ubiquitination regulation of protein modification by small protein conjugation or removal positive regulation of protein modification by small protein conjugation or removal positive regulation of protein ubiquitination regulation of post-translational protein modification post-translational protein modification protein modification by small protein conjugation protein modification by small protein conjugation or removal regulation of tumor necrosis factor production tumor necrosis factor superfamily cytokine production tumor necrosis factor production regulation of tumor necrosis factor superfamily cytokine production regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction neuron apoptotic process negative regulation of neuron apoptotic process regulation of neuron apoptotic process positive regulation of cell adhesion regulation of blood vessel endothelial cell migration blood vessel endothelial cell migration positive regulation of blood vessel endothelial cell migration cell population proliferation skeletal muscle satellite cell proliferation regulation of cell population proliferation muscle cell proliferation regulation of skeletal muscle satellite cell proliferation skeletal muscle cell proliferation regulation of skeletal muscle cell proliferation striated muscle cell proliferation regulation of blood-brain barrier permeability maintenance of blood-brain barrier homeostatic process positive regulation of vascular permeability positive regulation of blood-brain barrier permeability tissue homeostasis multicellular organismal-level homeostasis anatomical structure homeostasis negative regulation of endothelial cell apoptotic process regulation of epithelial cell apoptotic process epithelial cell apoptotic process negative regulation of epithelial cell apoptotic process endothelial cell apoptotic process regulation of endothelial cell apoptotic process cell-substrate adhesion peptidyl-tyrosine modification positive regulation of peptidyl-tyrosine phosphorylation regulation of peptidyl-tyrosine phosphorylation peptidyl-tyrosine phosphorylation canonical NF-kappaB signal transduction regulation of canonical NF-kappaB signal transduction response to organic substance response to cytokine cytokine-mediated signaling pathway macrophage migration inhibitory factor signaling pathway cellular response to cytokine stimulus cellular response to organic substance regulation of macrophage migration inhibitory factor signaling pathway regulation of cytokine-mediated signaling pathway cellular response to chemical stimulus regulation of response to cytokine stimulus	extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix cell projection actin-based cell projection microvillus plasma membrane bounded cell projection plasma membrane membrane membrane microdomain membrane raft

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A	IPR008266	Tyrosine-protein kinase, active site	Active Site
A	IPR020635	Tyrosine-protein kinase, catalytic domain	Domain
A	IPR000719	Protein kinase domain	Domain
A	IPR002049	Laminin-type EGF domain	Domain
A	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A	IPR007110	Immunoglobulin-like domain	Domain
A	IPR017441	Protein kinase, ATP binding site	Binding Site
A	IPR018941	Tyrosine-protein kinase, receptor Tie-2, Ig-like domain 1, N-terminal	Domain
A	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain	Domain
A	IPR000742	EGF-like domain	Domain
A	IPR003961	Fibronectin type III	Domain
A	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A	IPR036116	Fibronectin type III superfamily	Homologous Superfamily
B	IPR014716	Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1	Homologous Superfamily
B	IPR020837	Fibrinogen, conserved site	Conserved Site
B	IPR002181	Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain	Domain
B	IPR036056	Fibrinogen-like, C-terminal	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q02763	multiple cutaneous and mucosal venous malformations glaucoma 3, primary congenital, E angiosarcoma blue rubber bleb nevus Liver Neoplasms, Experimental temporal lobe epilepsy glaucoma 3, primary infantile, B intellectual disability large cell medulloblastoma lung cancer adrenal cortex carcinoma oligodendroglioma ovarian serous adenocarcinoma renal cell carcinoma hepatocellular carcinoma multiple cutaneous and mucosal venous malformations glaucoma 3, primary congenital, E angiosarcoma blue rubber bleb nevus Liver Neoplasms, Experimental temporal lobe epilepsy glaucoma 3, primary infantile, B intellectual disability large cell medulloblastoma lung cancer adrenal cortex carcinoma oligodendroglioma ovarian serous adenocarcinoma renal cell carcinoma hepatocellular carcinoma hereditary hemorrhagic telangiectasia interstitial cystitis lung carcinoma medullary thyroid gland carcinoma osteosarcoma cancer pancreatic intraductal papillary-mucinous carcinoma cystic fibrosis primary congenital glaucoma hydrophthalmos invasive ductal breast carcinoma lung adenocarcinoma malignant ependymoma non-small cell lung carcinoma astrocytic tumor ovarian cancer cerebrovascular disorder pancreatic intraductal papillary-mucinous neoplasm psoriasis glaucoma ulcerative colitis glioblastoma
B	Pharos: Q15389	Hypertrophy ovarian cancer pituitary cancer breast cancer cystic fibrosis glioblastoma invasive ductal breast carcinoma lung carcinoma malignant glioma open-angle glaucoma pancreatic intraductal papillary-mucinous carcinoma breast carcinoma ductal breast carcinoma in situ lung adenocarcinoma malignant colon neoplasm Hypertrophy ovarian cancer pituitary cancer breast cancer cystic fibrosis glioblastoma invasive ductal breast carcinoma lung carcinoma malignant glioma open-angle glaucoma pancreatic intraductal papillary-mucinous carcinoma breast carcinoma ductal breast carcinoma in situ lung adenocarcinoma malignant colon neoplasm malignant mesothelioma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm lung cancer malignant ependymoma non-small cell lung carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.