Annotations: 4K0D

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Chemoreceptors ligand-binding domain	8018648	3001511	SCOP2B (2022-06-29)
B	SCOP2 Family	Histidine kinase HK9 sensory domain - like	8018647	4004020	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	Chemoreceptors ligand-binding domain	8018648	3001511	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	EUF08104	e4k0dA1	A: alpha bundles	X: Four-helical up-and-down bundle	H: Histidine kinase associated sensor domains (From Topology)	T: Histidine kinase associated sensor domains	F: EUF08104	ECOD (1.6)
B	EUF08104	e4k0dB1	A: alpha bundles	X: Four-helical up-and-down bundle	H: Histidine kinase associated sensor domains (From Topology)	T: Histidine kinase associated sensor domains	F: EUF08104	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.120.1730	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)		CATH (4.3.0)
B	1.20.120.1730	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)		CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Periplasmic sensor hybrid histidine kinase	catalytic activity, acting on a protein small molecule sensor activity kinase activity protein kinase activity transferase activity phosphotransferase activity, nitrogenous group as acceptor phosphotransferase activity, alcohol group as acceptor protein histidine kinase activity transferase activity, transferring phosphorus-containing groups phosphorelay sensor kinase activity catalytic activity cation binding ion binding binding catalytic activity, acting on a protein small molecule sensor activity kinase activity protein kinase activity transferase activity phosphotransferase activity, nitrogenous group as acceptor phosphotransferase activity, alcohol group as acceptor protein histidine kinase activity transferase activity, transferring phosphorus-containing groups phosphorelay sensor kinase activity catalytic activity cation binding ion binding binding metal ion binding small molecule binding	-	membrane cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR005467	Histidine kinase domain	Domain
A, B	IPR011006	CheY-like superfamily	Homologous Superfamily
A, B	IPR004358	Signal transduction histidine kinase-related protein, C-terminal	Domain
A, B	IPR001789	Signal transduction response regulator, receiver domain	Domain
A, B	IPR003594	Histidine kinase/HSP90-like ATPase	Domain
A, B	IPR036097	Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily	Homologous Superfamily
A, B	IPR003660	HAMP domain	Domain
A, B	IPR036890	Histidine kinase/HSP90-like ATPase superfamily	Homologous Superfamily
A, B	IPR003661	Signal transduction histidine kinase, dimerisation/phosphoacceptor domain	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.