4JXT

CID of human RPRD1A in complex with a phosphorylated peptide from RPB1-CTD

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Pcf11 CTD-interacting domain (CID)-like	8046497	4002665	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	ENTH/VHS domain-like	8053994	3000164	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF04818	e4jxtA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF04818	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.25.40.90	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF04818	CID domain (CID)	CID domain	-	Repeat
B	PF05001	RNA polymerase Rpb1 C-terminal repeat (RNA_pol_Rpb1_R)	RNA polymerase Rpb1 C-terminal repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Regulation of nuclear pre-mRNA domain-containing protein 1A	basal transcription machinery binding RNA polymerase binding protein binding binding RNA polymerase II complex binding basal RNA polymerase II transcription machinery binding RNA polymerase II C-terminal domain binding RNA polymerase core enzyme binding enzyme binding identical protein binding	cellular biosynthetic process mRNA 3'-end processing cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process mRNA processing mRNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process cellular biosynthetic process mRNA 3'-end processing cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process mRNA processing mRNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process nucleic acid catabolic process RNA 3'-end processing metabolic process cellular process RNA processing macromolecule metabolic process RNA polymerase II promoter clearance RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II promoter clearance during DNA-templated transcription nucleobase-containing compound biosynthetic process organic cyclic compound biosynthetic process	transcription preinitiation complex protein-containing complex protein-DNA complex membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle transcription preinitiation complex protein-containing complex protein-DNA complex membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen
B	DNA-directed RNA polymerase II subunit RPB1	5'-3' RNA polymerase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA polymerase activity transferase activity RNA-dependent RNA polymerase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups extracellular matrix binding binding microfibril binding RNA binding organic cyclic compound binding 5'-3' RNA polymerase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA polymerase activity transferase activity RNA-dependent RNA polymerase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups extracellular matrix binding binding microfibril binding RNA binding organic cyclic compound binding nucleic acid binding protein-containing complex binding chromatin binding promoter-specific chromatin binding DNA binding protein binding kinase binding enzyme binding DNA-directed 5'-3' RNA polymerase activity RNA polymerase II activity ubiquitin protein ligase binding ubiquitin-like protein ligase binding cation binding ion binding metal ion binding small molecule binding	cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription organic cyclic compound metabolic process nucleic acid biosynthetic process transcription by RNA polymerase II organic substance metabolic process cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription organic cyclic compound metabolic process nucleic acid biosynthetic process transcription by RNA polymerase II organic substance metabolic process biosynthetic process organic cyclic compound biosynthetic process organic substance biosynthetic process metabolic process cellular process macromolecule metabolic process DNA-templated transcription termination regulation of cellular process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process positive regulation of metabolic process regulation of RNA metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process RNA processing regulation of nucleobase-containing compound metabolic process positive regulation of cellular process regulation of biosynthetic process RNA splicing positive regulation of nucleobase-containing compound metabolic process regulation of biological process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process regulation of RNA splicing positive regulation of RNA metabolic process regulation of cellular biosynthetic process regulation of gene expression positive regulation of gene expression regulation of macromolecule biosynthetic process positive regulation of RNA splicing regulation of metabolic process positive regulation of cellular biosynthetic process regulation of RNA biosynthetic process regulation of DNA-templated transcription	membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transferase complex intracellular organelle lumen intracellular organelle nucleoplasm RNA polymerase II, core complex catalytic complex intracellular membrane-bounded organelle membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transferase complex intracellular organelle lumen intracellular organelle nucleoplasm RNA polymerase II, core complex catalytic complex intracellular membrane-bounded organelle cellular anatomical entity transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex organelle lumen organelle RNA polymerase complex DNA-directed RNA polymerase complex intracellular protein-containing complex nuclear lumen cytoplasm intracellular non-membrane-bounded organelle chromosome non-membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR032337	RPRD1A/B, C-terminal domain	Domain
A	IPR006569	CID domain	Domain
A	IPR008942	ENTH/VHS	Homologous Superfamily
A	IPR047884	RPRD1A, CID domain	Domain
B	IPR007081	RNA polymerase Rpb1, domain 5	Domain
B	IPR045867	DNA-directed RNA polymerase, subunit beta-prime	Family
B	IPR007075	RNA polymerase Rpb1, domain 6	Domain
B	IPR000684	RNA polymerase II, heptapeptide repeat, eukaryotic	Repeat
B	IPR007083	RNA polymerase Rpb1, domain 4	Domain
B	IPR044893	RNA polymerase Rpb1, clamp domain superfamily	Homologous Superfamily
B	IPR006592	RNA polymerase, N-terminal	Domain
B	IPR007066	RNA polymerase Rpb1, domain 3	Domain
B	IPR007073	RNA polymerase Rpb1, domain 7	Domain
B	IPR042102	RNA polymerase Rpb1, domain 3 superfamily	Homologous Superfamily
B	IPR038593	RNA polymerase Rpb1, domain 7 superfamily	Homologous Superfamily
B	IPR000722	RNA polymerase, alpha subunit	Domain
B	IPR038120	RNA polymerase Rpb1, funnel domain superfamily	Homologous Superfamily
B	IPR007080	RNA polymerase Rpb1, domain 1	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q96P16	adenoma carcinoma of esophagus hereditary spastic paraplegia lung cancer non-small cell lung carcinoma ovarian cancer squamous cell carcinoma atypical teratoid rhabdoid tumor cystic fibrosis IgA glomerulonephritis malignant glioma oligodendroglioma pancreatic ductal adenocarcinoma tuberculosis breast cancer adenoma carcinoma of esophagus hereditary spastic paraplegia lung cancer non-small cell lung carcinoma ovarian cancer squamous cell carcinoma atypical teratoid rhabdoid tumor cystic fibrosis IgA glomerulonephritis malignant glioma oligodendroglioma pancreatic ductal adenocarcinoma tuberculosis breast cancer glioblastoma invasive ductal breast carcinoma Malignant neoplasm of breast osteosarcoma psoriasis
B	Pharos: P24928	acute myeloid leukemia central nervous system cancer metabolic syndrome X astrocytic tumor diabetes mellitus osteosarcoma atrial fibrillation IgA glomerulonephritis uterine corpus leiomyoma

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
B	BTN	RESID: AA0117 PSI-MOD : N6-biotinyl-L-lysine MOD:00126
B	NH2	RESID: AA0117 , AA0081 , AA0083 , AA0084 , AA0086 , AA0087 , AA0088 , AA0090 , AA0091 , AA0092 , AA0093 , AA0095 , AA0096 , AA0097 , AA0098 , AA0099 , AA0100 PSI-MOD : N6-biotinyl-L-lysine MOD:00126 , L-alanine amide MOD:00090 , L-asparagine amide MOD:00092 , L-aspartic acid 1-amide MOD:00093 , L-glutamine amide MOD:00095 , L-glutamic acid 1-amide MOD:00096 , glycine amide MOD:00097 , L-isoleucine amide MOD:00099 , L-leucine amide MOD:00100 , L-lysine amide MOD:00101 , L-methionine amide MOD:00102 , L-proline amide MOD:00104 , L-serine amide MOD:00105 , L-threonine amide MOD:00106 , L-tryptophan amide MOD:00107 , L-tyrosine amide MOD:00108 , L-valine amide MOD:00109
B	SEP	Parent Component: SER RESID: AA0117 , AA0081 , AA0083 , AA0084 , AA0086 , AA0087 , AA0088 , AA0090 , AA0091 , AA0092 , AA0093 , AA0095 , AA0096 , AA0097 , AA0098 , AA0099 , AA0100 , AA0037 PSI-MOD : N6-biotinyl-L-lysine MOD:00126 , L-alanine amide MOD:00090 , L-asparagine amide MOD:00092 , L-aspartic acid 1-amide MOD:00093 , L-glutamine amide MOD:00095 , L-glutamic acid 1-amide MOD:00096 , glycine amide MOD:00097 , L-isoleucine amide MOD:00099 , L-leucine amide MOD:00100 , L-lysine amide MOD:00101 , L-methionine amide MOD:00102 , L-proline amide MOD:00104 , L-serine amide MOD:00105 , L-threonine amide MOD:00106 , L-tryptophan amide MOD:00107 , L-tyrosine amide MOD:00108 , L-valine amide MOD:00109 , O-phospho-L-serine MOD:00046

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.