4JLS

Crystal Structure of E. coli XGPRT in complex with (3R,4S)-4-(Guanin-9-yl)-3-hydroxypyrrolidin-1-N-ylacetylphosphonic acid

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4jlsa_	Alpha and beta proteins (a/b)	PRTase-like	PRTase-like	Phosphoribosyltransferases (PRTases)	Xanthine-guanine PRTase (XPRTase)	(Escherichia coli str. K-12 substr. MDS42 ) [TaxId: 1110693 ],	SCOPe (2.08)
B	d4jlsb_	Alpha and beta proteins (a/b)	PRTase-like	PRTase-like	Phosphoribosyltransferases (PRTases)	Xanthine-guanine PRTase (XPRTase)	(Escherichia coli str. K-12 substr. MDS42 ) [TaxId: 1110693 ],	SCOPe (2.08)
C	d4jlsc_	Alpha and beta proteins (a/b)	PRTase-like	PRTase-like	Phosphoribosyltransferases (PRTases)	Xanthine-guanine PRTase (XPRTase)	(Escherichia coli str. K-12 substr. MDS42 ) [TaxId: 1110693 ],	SCOPe (2.08)
D	d4jlsd_	Alpha and beta proteins (a/b)	PRTase-like	PRTase-like	Phosphoribosyltransferases (PRTases)	Xanthine-guanine PRTase (XPRTase)	(Escherichia coli str. K-12 substr. MDS42 ) [TaxId: 1110693 ],	SCOPe (2.08)
E	d4jlse_	Alpha and beta proteins (a/b)	PRTase-like	PRTase-like	Phosphoribosyltransferases (PRTases)	Xanthine-guanine PRTase (XPRTase)	(Escherichia coli str. K-12 substr. MDS42 ) [TaxId: 1110693 ],	SCOPe (2.08)
F [auth H]	d4jlsh_	Alpha and beta proteins (a/b)	PRTase-like	PRTase-like	Phosphoribosyltransferases (PRTases)	Xanthine-guanine PRTase (XPRTase)	(Escherichia coli str. K-12 substr. MDS42 ) [TaxId: 1110693 ],	SCOPe (2.08)
G [auth I]	d4jlsi_	Alpha and beta proteins (a/b)	PRTase-like	PRTase-like	Phosphoribosyltransferases (PRTases)	Xanthine-guanine PRTase (XPRTase)	(Escherichia coli str. K-12 substr. MDS42 ) [TaxId: 1110693 ],	SCOPe (2.08)
H [auth J]	d4jlsj_	Alpha and beta proteins (a/b)	PRTase-like	PRTase-like	Phosphoribosyltransferases (PRTases)	Xanthine-guanine PRTase (XPRTase)	(Escherichia coli str. K-12 substr. MDS42 ) [TaxId: 1110693 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	PRTase-like	8032217	3000060	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	PRTase-like	8032217	3000060	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	PRTase-like	8032217	3000060	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	PRTase-like	8032217	3000060	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	PRTase-like	8032217	3000060	SCOP2B (2022-06-29)
F [auth H]	SCOP2B Superfamily	PRTase-like	8032217	3000060	SCOP2B (2022-06-29)
G [auth I]	SCOP2B Superfamily	PRTase-like	8032217	3000060	SCOP2B (2022-06-29)
H [auth J]	SCOP2B Superfamily	PRTase-like	8032217	3000060	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00156	e4jlsA1	A: a/b three-layered sandwiches	X: PRTase-like (From Topology)	H: PRTase-like (From Topology)	T: PRTase-like	F: PF00156	ECOD (1.6)
B	PF00156	e4jlsB1	A: a/b three-layered sandwiches	X: PRTase-like (From Topology)	H: PRTase-like (From Topology)	T: PRTase-like	F: PF00156	ECOD (1.6)
C	PF00156	e4jlsC1	A: a/b three-layered sandwiches	X: PRTase-like (From Topology)	H: PRTase-like (From Topology)	T: PRTase-like	F: PF00156	ECOD (1.6)
D	PF00156	e4jlsD1	A: a/b three-layered sandwiches	X: PRTase-like (From Topology)	H: PRTase-like (From Topology)	T: PRTase-like	F: PF00156	ECOD (1.6)
E	PF00156	e4jlsE1	A: a/b three-layered sandwiches	X: PRTase-like (From Topology)	H: PRTase-like (From Topology)	T: PRTase-like	F: PF00156	ECOD (1.6)
F [auth H]	PF00156	e4jlsH1	A: a/b three-layered sandwiches	X: PRTase-like (From Topology)	H: PRTase-like (From Topology)	T: PRTase-like	F: PF00156	ECOD (1.6)
G [auth I]	PF00156	e4jlsI1	A: a/b three-layered sandwiches	X: PRTase-like (From Topology)	H: PRTase-like (From Topology)	T: PRTase-like	F: PF00156	ECOD (1.6)
H [auth J]	PF00156	e4jlsJ1	A: a/b three-layered sandwiches	X: PRTase-like (From Topology)	H: PRTase-like (From Topology)	T: PRTase-like	F: PF00156	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.2020	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
B	3.40.50.2020	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
C	3.40.50.2020	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
D	3.40.50.2020	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
E	3.40.50.2020	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
F [auth H]	3.40.50.2020	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
G [auth I]	3.40.50.2020	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
H [auth J]	3.40.50.2020	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E, A, B, C, D, E, F [auth H], G [auth I], H [auth J]	PF00156	Phosphoribosyl transferase domain (Pribosyltran)	Phosphoribosyl transferase domain	This family includes a range of diverse phosphoribosyl transferase enzymes. This family includes: Adenine phosphoribosyl-transferase EC:2.4.2.7, Swiss:P07672. Hypoxanthine-guanine-xanthine phosphoribosyl-transferase Swiss:P51900. Hypoxanthine phosph ...	This family includes a range of diverse phosphoribosyl transferase enzymes. This family includes: Adenine phosphoribosyl-transferase EC:2.4.2.7, Swiss:P07672. Hypoxanthine-guanine-xanthine phosphoribosyl-transferase Swiss:P51900. Hypoxanthine phosphoribosyl-transferase EC:2.4.2.8 Swiss:P36766. Ribose-phosphate pyrophosphokinase i EC:2.7.6.1 Swiss:P09329. Amidophosphoribosyltransferase EC:2.4.2.14 Swiss:P00496. Orotate phosphoribosyl-transferase EC:2.4.2.10 Swiss:P11172. Uracil phosphoribosyl-transferase EC:2.4.2.9 Swiss:P25532. Xanthine-guanine phosphoribosyl-transferase EC:2.4.2.22 Swiss:P00501. In Arabidopsis, At the very N-terminus of this domain is the P-Loop NTPase domain [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E, A, B, C, D, E, F [auth H], G [auth I], H [auth J]	Xanthine phosphoribosyltransferase	cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding pentosyltransferase activity hypoxanthine phosphoribosyltransferase activity glycosyltransferase activity purine phosphoribosyltransferase activity transferase activity catalytic activity guanosine tetraphosphate binding guanyl nucleotide binding cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding pentosyltransferase activity hypoxanthine phosphoribosyltransferase activity glycosyltransferase activity purine phosphoribosyltransferase activity transferase activity catalytic activity guanosine tetraphosphate binding guanyl nucleotide binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding xanthine phosphoribosyltransferase activity guanine phosphoribosyltransferase activity identical protein binding protein binding	glycosyl compound metabolic process organonitrogen compound biosynthetic process carbohydrate derivative metabolic process nucleoside biosynthetic process nucleobase-containing compound metabolic process organic substance metabolic process nucleobase-containing small molecule metabolic process purine-containing compound biosynthetic process organic substance biosynthetic process small molecule metabolic process cellular metabolic compound salvage purine ribonucleoside metabolic process carbohydrate derivative biosynthetic process organonitrogen compound metabolic process glycosyl compound metabolic process organonitrogen compound biosynthetic process carbohydrate derivative metabolic process nucleoside biosynthetic process nucleobase-containing compound metabolic process organic substance metabolic process nucleobase-containing small molecule metabolic process purine-containing compound biosynthetic process organic substance biosynthetic process small molecule metabolic process cellular metabolic compound salvage purine ribonucleoside metabolic process carbohydrate derivative biosynthetic process organonitrogen compound metabolic process glycosyl compound biosynthetic process purine-containing compound salvage small molecule biosynthetic process nucleoside salvage cellular metabolic process purine ribonucleoside biosynthetic process primary metabolic process ribonucleoside biosynthetic process nucleobase-containing compound biosynthetic process nucleoside metabolic process nucleobase-containing small molecule biosynthetic process purine-containing compound metabolic process purine ribonucleoside salvage organic cyclic compound metabolic process biosynthetic process purine nucleoside biosynthetic process organic cyclic compound biosynthetic process metabolic process cellular process purine nucleoside metabolic process ribonucleoside metabolic process purine ribonucleoside monophosphate biosynthetic process nucleotide biosynthetic process purine ribonucleotide biosynthetic process ribonucleotide biosynthetic process purine nucleoside monophosphate biosynthetic process purine nucleoside monophosphate metabolic process phosphate-containing compound metabolic process GMP metabolic process phosphorus metabolic process ribose phosphate biosynthetic process nucleoside phosphate metabolic process GMP salvage GMP biosynthetic process nucleotide metabolic process purine ribonucleotide salvage organophosphate biosynthetic process nucleoside phosphate biosynthetic process purine ribonucleotide metabolic process purine nucleotide biosynthetic process ribose phosphate metabolic process nucleotide salvage purine ribonucleoside monophosphate metabolic process purine nucleotide metabolic process ribonucleotide metabolic process ribonucleoside monophosphate metabolic process purine nucleotide salvage nucleoside monophosphate metabolic process nucleoside monophosphate biosynthetic process organophosphate metabolic process ribonucleoside monophosphate biosynthetic process IMP salvage IMP metabolic process IMP biosynthetic process protein-containing complex organization protein homotetramerization cellular component organization cellular component biogenesis cellular component assembly protein complex oligomerization protein tetramerization protein-containing complex assembly protein homooligomerization cellular component organization or biogenesis XMP salvage XMP biosynthetic process XMP metabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cell periphery plasma membrane membrane protein-containing complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E, A, B, C, D, E, F [auth H], G [auth I], H [auth J]	IPR000836	Phosphoribosyltransferase domain	Domain
A, B, C, D, E, A, B, C, D, E, F [auth H], G [auth I], H [auth J]	IPR023747	Xanthine-guanine phosphoribosyltransferase	Family
A, B, C, D, E, A, B, C, D, E, F [auth H], G [auth I], H [auth J]	IPR029057	Phosphoribosyltransferase-like	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.