Annotations: 4JF7

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth D]	SCOP2B Superfamily	Sialidases	8080111	3001607	SCOP2B (2022-06-29)
B [auth A]	SCOP2B Superfamily	Sialidases	8080111	3001607	SCOP2B (2022-06-29)
C [auth B]	SCOP2B Superfamily	Sialidases	8080111	3001607	SCOP2B (2022-06-29)
D [auth C]	SCOP2B Superfamily	Sialidases	8080111	3001607	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth D]	HN	e4jf7D1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: HN	ECOD (1.6)
B [auth A]	HN	e4jf7A1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: HN	ECOD (1.6)
C [auth B]	HN	e4jf7B1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: HN	ECOD (1.6)
D [auth C]	HN	e4jf7C1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: HN	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth D]	1.20.5.110	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
A [auth D]	2.120.10.10	Mainly Beta	6 Propeller	Neuraminidase		CATH (4.3.0)
B [auth A]	1.20.5.110	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
B [auth A]	2.120.10.10	Mainly Beta	6 Propeller	Neuraminidase		CATH (4.3.0)
C [auth B]	1.20.5.110	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
C [auth B]	2.120.10.10	Mainly Beta	6 Propeller	Neuraminidase		CATH (4.3.0)
D [auth C]	1.20.5.110	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
D [auth C]	2.120.10.10	Mainly Beta	6 Propeller	Neuraminidase		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth D], B [auth A], C [auth B], D [auth C]	PF00423	Haemagglutinin-neuraminidase (HN)	Haemagglutinin-neuraminidase	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth D], B [auth A], C [auth B], D [auth C]	Hemagglutinin-neuraminidase	hydrolase activity, acting on glycosyl bonds exo-alpha-(2->6)-sialidase activity alpha-sialidase activity hydrolase activity, hydrolyzing O-glycosyl compounds hydrolase activity exo-alpha-sialidase activity catalytic activity exo-alpha-(2->8)-sialidase activity exo-alpha-(2->3)-sialidase activity identical protein binding protein binding binding host cell surface binding host cell surface receptor binding	virion attachment to host cell biological process involved in interspecies interaction between organisms adhesion of symbiont to host cell viral process viral life cycle adhesion of symbiont to host biological process involved in interaction with host biological process involved in symbiotic interaction non-lytic viral release viral budding virion assembly exit from host cell viral budding from plasma membrane viral release from host cell virion attachment to host cell biological process involved in interspecies interaction between organisms adhesion of symbiont to host cell viral process viral life cycle adhesion of symbiont to host biological process involved in interaction with host biological process involved in symbiotic interaction non-lytic viral release viral budding virion assembly exit from host cell viral budding from plasma membrane viral release from host cell symbiont entry into host cell symbiont entry into host	membrane cellular anatomical entity virion component virion membrane viral membrane viral envelope host cell plasma membrane host cellular component host cell part host cell membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth D], B [auth A], C [auth B], D [auth C]	IPR016285	Haemagglutinin-neuraminidase	Family
A [auth D], B [auth A], C [auth B], D [auth C]	IPR036278	Sialidase superfamily	Homologous Superfamily
A [auth D], B [auth A], C [auth B], D [auth C]	IPR000665	Haemagglutinin/haemagglutinin-neuraminidase, paramyxovirus	Family

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.