4J9U

Crystal Structure of the TrkH/TrkA potassium transport complex

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF02386	e4j9uA1	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: PF02386	ECOD (1.6)
B	PF02386	e4j9uB5	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: PF02386	ECOD (1.6)
C	PF02386	e4j9uC9	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: PF02386	ECOD (1.6)
D	PF02386	e4j9uD9	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: PF02386	ECOD (1.6)
E	PF02080	e4j9uE7	A: a+b two layers	X: TrkA C-terminal domain-like (From Topology)	H: TrkA C-terminal domain-like (From Topology)	T: TrkA C-terminal domain-like	F: PF02080	ECOD (1.6)
E	PF02254	e4j9uE5	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF02254	ECOD (1.6)
F	PF02080	e4j9uF11	A: a+b two layers	X: TrkA C-terminal domain-like (From Topology)	H: TrkA C-terminal domain-like (From Topology)	T: TrkA C-terminal domain-like	F: PF02080	ECOD (1.6)
F	PF02254	e4j9uF9	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF02254	ECOD (1.6)
G	PF02080	e4j9uG3	A: a+b two layers	X: TrkA C-terminal domain-like (From Topology)	H: TrkA C-terminal domain-like (From Topology)	T: TrkA C-terminal domain-like	F: PF02080	ECOD (1.6)
G	PF02254	e4j9uG1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF02254	ECOD (1.6)
H	PF02080	e4j9uH7	A: a+b two layers	X: TrkA C-terminal domain-like (From Topology)	H: TrkA C-terminal domain-like (From Topology)	T: TrkA C-terminal domain-like	F: PF02080	ECOD (1.6)
H	PF02254	e4j9uH5	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF02254	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
E	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)
E	3.30.70.1450	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	Regulator of K+ conductance, C-terminal domain	CATH (4.3.0)
F	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)
F	3.30.70.1450	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	Regulator of K+ conductance, C-terminal domain	CATH (4.3.0)
G	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)
G	3.30.70.1450	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	Regulator of K+ conductance, C-terminal domain	CATH (4.3.0)
H	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)
H	3.30.70.1450	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	Regulator of K+ conductance, C-terminal domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF02386	Cation transport protein (TrkH)	Cation transport protein	-	Family
E, F, G, H	PF02080	TrkA-C domain (TrkA_C)	TrkA-C domain	This domain is often found next to the Pfam:PF02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand [1]. The domain is predicted to adopt an all beta structure [1].	Domain
E, F, G, H	PF02254	TrkA-N domain (TrkA_N)	TrkA-N domain	This domain is found in a wide variety of proteins. These protein include potassium channels Swiss:P31069, phosphoesterases Swiss:Q59027, and various other transporters. This domain binds to NAD.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Trk system potassium uptake protein TrkH	cation binding ion binding binding potassium ion binding alkali metal ion binding metal ion binding small molecule binding identical protein binding protein binding protein homodimerization activity protein dimerization activity monoatomic cation transmembrane transporter activity monoatomic anion transmembrane transporter activity chloride transmembrane transporter activity cation binding ion binding binding potassium ion binding alkali metal ion binding metal ion binding small molecule binding identical protein binding protein binding protein homodimerization activity protein dimerization activity monoatomic cation transmembrane transporter activity monoatomic anion transmembrane transporter activity chloride transmembrane transporter activity solute:monoatomic cation symporter activity potassium ion transmembrane transporter activity monoatomic anion:monoatomic cation symporter activity secondary active transmembrane transporter activity chloride:monoatomic cation symporter activity active monoatomic ion transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity symporter activity potassium:chloride symporter activity inorganic anion transmembrane transporter activity monoatomic ion channel activity potassium channel activity monoatomic cation channel activity passive transmembrane transporter activity channel activity	transport monoatomic ion transmembrane transport potassium ion transmembrane transport inorganic ion transmembrane transport establishment of localization metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport potassium ion transport cellular process monoatomic cation transport	cell periphery plasma membrane membrane cellular anatomical entity
E, F, G, H	Potassium uptake protein TrkA	monoatomic cation transmembrane transporter activity potassium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity binding nucleoside phosphate binding organic cyclic compound binding nucleotide binding heterocyclic compound binding small molecule binding	-	cell periphery plasma membrane membrane cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR003445	Cation transporter	Family
A, B, C, D	IPR004772	TrkH potassium transport family	Family
E, F, G, H	IPR006037	Regulator of K+ conductance, C-terminal	Domain
E, F, G, H	IPR036291	NAD(P)-binding domain superfamily	Homologous Superfamily
E, F, G, H	IPR036721	Regulator of K+ conductance, C-terminal domain superfamily	Homologous Superfamily
E, F, G, H	IPR006036	Potassium uptake protein TrkA	Family
E, F, G, H	IPR003148	Regulator of K+ conductance, N-terminal	Domain

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B, C, D	OPM	Transmembrane	Alpha-helical polytopic	Ion channel (VIC) superfamily	Potassium transporter TrkH/TrkA complex

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B, C, D	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B, C, D	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B, C, D	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Superfamily of K⁺ Transporters (SKT proteins)	TrkH potassium ion transporter in complex with TrkA

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.