Annotations: 4J8S

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	CCR4-NOT transcription complex subunit 1 TTP binding domain	8045555	4004529	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	ARM repeat-like	8053819	3000116	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF16417	e4j8sA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF16417	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.25.40.840	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat	CCR4-NOT transcription complex subunit 1 TTP binding domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF16417	CCR4-NOT transcription complex subunit 1 TTP binding domain (CNOT1_TTP_bind)	CCR4-NOT transcription complex subunit 1 TTP binding domain	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	CCR4-NOT transcription complex subunit 1	protein binding binding protein domain specific binding transcription factor binding nuclear retinoic acid receptor binding RNA polymerase II-specific DNA-binding transcription factor binding nuclear receptor binding DNA-binding transcription factor binding RNA binding organic cyclic compound binding nucleic acid binding armadillo repeat domain binding molecular adaptor activity nuclear estrogen receptor binding	developmental process multicellular organismal process regulation of biological process regulation of developmental process biological regulation regulation of stem cell population maintenance regulation of multicellular organismal process maintenance of cell number stem cell population maintenance regulation of cellular process cellular biosynthetic process organonitrogen compound biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process developmental process multicellular organismal process regulation of biological process regulation of developmental process biological regulation regulation of stem cell population maintenance regulation of multicellular organismal process maintenance of cell number stem cell population maintenance regulation of cellular process cellular biosynthetic process organonitrogen compound biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process post-transcriptional regulation of gene expression negative regulation of translation organic substance metabolic process organic substance biosynthetic process negative regulation of cellular process protein metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process organonitrogen compound metabolic process cellular metabolic process regulation of protein metabolic process negative regulation of metabolic process regulation of cellular metabolic process primary metabolic process regulation of macromolecule metabolic process gene expression translation macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process regulation of translation negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process regulation of metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process regulation of RNA metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of biological quality RNA catabolic process mRNA catabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of mRNA metabolic process nucleobase-containing compound catabolic process nuclear-transcribed mRNA poly(A) tail shortening positive regulation of RNA metabolic process organic cyclic compound metabolic process nucleic acid catabolic process nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay catabolic process positive regulation of biological process RNA metabolic process macromolecule catabolic process mRNA destabilization regulation of mRNA catabolic process nuclear-transcribed mRNA catabolic process RNA destabilization regulation of catabolic process mRNA metabolic process nucleic acid metabolic process organic cyclic compound catabolic process positive regulation of catabolic process regulation of mRNA stability positive regulation of mRNA catabolic process regulation of RNA stability regulation of mRNA metabolic process organic substance catabolic process positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay trophectodermal cell differentiation cellular developmental process chordate embryonic development embryo development in utero embryonic development multicellular organism development anatomical structure morphogenesis blastocyst formation embryo development ending in birth or egg hatching cell differentiation anatomical structure development anatomical structure formation involved in morphogenesis blastocyst development positive regulation of nuclear-transcribed mRNA poly(A) tail shortening regulation of nuclear-transcribed mRNA poly(A) tail shortening positive regulation of organelle organization regulation of cellular component organization positive regulation of cellular component organization positive regulation of cytoplasmic mRNA processing body assembly regulation of cytoplasmic mRNA processing body assembly non-membrane-bounded organelle assembly cellular component biogenesis cellular component organization cellular component assembly cellular component organization or biogenesis positive regulation of cellular process organelle assembly P-body assembly positive regulation of cellular component biogenesis regulation of cellular component biogenesis regulation of organelle organization organelle organization regulation of organelle assembly positive regulation of organelle assembly cellular response to stimulus intracellular receptor signaling pathway response to stimulus signaling negative regulation of signaling regulation of retinoic acid receptor signaling pathway regulation of signal transduction negative regulation of cell communication cell communication signal transduction regulation of signaling negative regulation of response to stimulus negative regulation of retinoic acid receptor signaling pathway retinoic acid receptor signaling pathway negative regulation of signal transduction regulation of response to stimulus regulation of cell communication response to organic substance response to lipid intracellular estrogen receptor signaling pathway hormone-mediated signaling pathway negative regulation of intracellular steroid hormone receptor signaling pathway cellular response to endogenous stimulus response to hormone response to steroid hormone regulation of intracellular steroid hormone receptor signaling pathway regulation of intracellular estrogen receptor signaling pathway cellular response to organic substance cellular response to steroid hormone stimulus response to organic cyclic compound negative regulation of intracellular estrogen receptor signaling pathway cellular response to hormone stimulus response to endogenous stimulus cellular response to organic cyclic compound cellular response to chemical stimulus steroid hormone mediated signaling pathway response to chemical cellular response to lipid nuclear receptor signaling pathway intracellular steroid hormone receptor signaling pathway negative regulation of RNA biosynthetic process DNA-templated transcription transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II organic cyclic compound biosynthetic process regulation of DNA-templated transcription negative regulation of RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process regulatory ncRNA-mediated post-transcriptional gene silencing regulatory ncRNA-mediated gene silencing miRNA-mediated post-transcriptional gene silencing post-transcriptional gene silencing	membrane cellular anatomical entity intracellular anatomical structure cytoplasm cytosol CCR4-NOT complex protein-containing complex intracellular protein-containing complex membrane-bounded organelle peroxisome intracellular membrane-bounded organelle microbody membrane intracellular organelle bounding membrane of organelle membrane cellular anatomical entity intracellular anatomical structure cytoplasm cytosol CCR4-NOT complex protein-containing complex intracellular protein-containing complex membrane-bounded organelle peroxisome intracellular membrane-bounded organelle microbody membrane intracellular organelle bounding membrane of organelle organelle peroxisomal membrane microbody organelle membrane cytoplasmic ribonucleoprotein granule ribonucleoprotein granule intracellular non-membrane-bounded organelle supramolecular complex P-body non-membrane-bounded organelle CCR4-NOT core complex extracellular region extracellular space nucleus
B	Tristetraprolin	protein binding binding heat shock protein binding 14-3-3 protein binding DNA binding organic cyclic compound binding nucleic acid binding RNA binding mRNA binding protein-containing complex binding C-C chemokine binding chemokine binding cytokine binding cation binding protein binding binding heat shock protein binding 14-3-3 protein binding DNA binding organic cyclic compound binding nucleic acid binding RNA binding mRNA binding protein-containing complex binding C-C chemokine binding chemokine binding cytokine binding cation binding ion binding metal ion binding small molecule binding mRNA 3'-UTR binding mRNA 3'-UTR AU-rich region binding RNA polymerase binding enzyme binding kinase binding protein kinase binding	cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation p38MAPK cascade intracellular signal transduction cell communication intracellular signaling cassette MAPK cascade cellular process signal transduction multicellular organismal process cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation p38MAPK cascade intracellular signal transduction cell communication intracellular signaling cassette MAPK cascade cellular process signal transduction multicellular organismal process cellular biosynthetic process negative regulation of biological process negative regulation of interleukin-2 production negative regulation of cellular metabolic process organic substance metabolic process regulation of cytokine production organic substance biosynthetic process cytokine production negative regulation of cellular process regulation of multicellular organismal process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of interleukin-2 production cellular metabolic process negative regulation of metabolic process regulation of cellular metabolic process interleukin-2 production negative regulation of cytokine production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process negative regulation of multicellular organismal process regulation of metabolic process catabolic process RNA metabolic process macromolecule catabolic process nucleobase-containing compound metabolic process RNA catabolic process nuclear-transcribed mRNA catabolic process, deadenylation-independent decay mRNA catabolic process nuclear-transcribed mRNA catabolic process primary metabolic process mRNA metabolic process nucleic acid metabolic process organic cyclic compound catabolic process nucleobase-containing compound catabolic process organic cyclic compound metabolic process nucleic acid catabolic process organic substance catabolic process regulation of developmental process cellular developmental process homeostatic process cell development regulation of cell differentiation regulation of cell development multicellular organism development negative regulation of erythrocyte differentiation cell differentiation anatomical structure development negative regulation of cell differentiation regulation of immune system process myeloid cell homeostasis erythrocyte homeostasis developmental process regulation of multicellular organismal development negative regulation of developmental process hemopoiesis regulation of myeloid cell differentiation negative regulation of myeloid cell differentiation erythrocyte differentiation regulation of erythrocyte differentiation multicellular organismal-level homeostasis myeloid cell differentiation immune system process regulation of hemopoiesis homeostasis of number of cells cell population proliferation regulation of cell population proliferation regulation of keratinocyte proliferation regulation of epithelial cell proliferation epithelial cell proliferation keratinocyte proliferation regulation of primary metabolic process post-transcriptional regulation of gene expression positive regulation of metabolic process regulation of RNA metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of biological quality positive regulation of nucleobase-containing compound metabolic process positive regulation of mRNA metabolic process positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay positive regulation of RNA metabolic process nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay positive regulation of biological process mRNA destabilization regulation of mRNA catabolic process regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay RNA destabilization regulation of catabolic process regulation of mRNA stability positive regulation of catabolic process positive regulation of mRNA catabolic process regulation of RNA stability regulation of mRNA metabolic process 3'-UTR-mediated mRNA destabilization response to fibroblast growth factor cellular response to endogenous stimulus cellular response to growth factor stimulus response to endogenous stimulus response to growth factor cellular response to fibroblast growth factor stimulus response to stress response to wounding negative regulation of RNA biosynthetic process DNA-templated transcription transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II organic cyclic compound biosynthetic process regulation of DNA-templated transcription negative regulation of RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process fat cell differentiation positive regulation of fat cell differentiation positive regulation of developmental process positive regulation of cell differentiation regulation of fat cell differentiation positive regulation of cellular process positive regulation of macromolecule biosynthetic process mRNA stabilization positive regulation of cellular metabolic process negative regulation of mRNA metabolic process 3'-UTR-mediated mRNA stabilization positive regulation of biosynthetic process negative regulation of catabolic process negative regulation of mRNA catabolic process negative regulation of RNA catabolic process RNA stabilization positive regulation of gene expression positive regulation of cellular biosynthetic process response to nutrient levels response to starvation regulation of miRNA-mediated gene silencing positive regulation of post-transcriptional gene silencing positive regulation of miRNA-mediated gene silencing regulation of gene silencing by regulatory ncRNA positive regulation of post-transcriptional gene silencing by RNA regulation of post-transcriptional gene silencing by regulatory ncRNA regulatory ncRNA-mediated post-transcriptional gene silencing regulatory ncRNA-mediated gene silencing miRNA-mediated post-transcriptional gene silencing regulation of post-transcriptional gene silencing post-transcriptional gene silencing RNA transport nitrogen compound transport transport organic substance transport nucleic acid transport mRNA transport establishment of localization localization establishment of RNA localization macromolecule localization RNA localization nucleobase-containing compound transport nuclear-transcribed mRNA poly(A) tail shortening regulation of localization cellular localization intracellular mRNA localization positive regulation of intracellular mRNA localization regulation of intracellular mRNA localization regulation of cellular localization cellular macromolecule localization regulation of defense response regulation of response to external stimulus negative regulation of inflammatory response defense response negative regulation of response to stimulus response to external stimulus regulation of inflammatory response regulation of response to stimulus negative regulation of response to external stimulus regulation of response to stress negative regulation of defense response inflammatory response response to organic substance biological process involved in interspecies interaction between organisms response to lipid response to other organism cellular response to lipopolysaccharide response to oxygen-containing compound cellular response to molecule of bacterial origin response to lipopolysaccharide cellular response to oxygen-containing compound response to biotic stimulus cellular response to biotic stimulus cellular response to chemical stimulus response to chemical response to bacterium cellular response to lipid cellular response to organic substance response to external biotic stimulus response to molecule of bacterial origin positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA RNA decapping deadenylation-independent decapping of nuclear-transcribed mRNA mRNA methylguanosine-cap decapping regulation of deadenylation-independent decapping of nuclear-transcribed mRNA organonitrogen compound biosynthetic process negative regulation of translation miRNA-mediated gene silencing by inhibition of translation protein metabolic process negative regulation of protein metabolic process organonitrogen compound metabolic process regulation of protein metabolic process translation regulation of translation regulation of tumor necrosis factor production tumor necrosis factor superfamily cytokine production tumor necrosis factor production regulation of tumor necrosis factor superfamily cytokine production negative regulation of stem cell differentiation negative regulation of hematopoietic progenitor cell differentiation regulation of stem cell differentiation hematopoietic stem cell differentiation negative regulation of hematopoietic stem cell differentiation regulation of hematopoietic progenitor cell differentiation regulation of hematopoietic stem cell differentiation stem cell differentiation hematopoietic progenitor cell differentiation positive regulation of nuclear-transcribed mRNA poly(A) tail shortening regulation of nuclear-transcribed mRNA poly(A) tail shortening regulation of epidermal cell differentiation epidermis development epithelial cell differentiation regulation of epithelial cell differentiation epithelium development epidermal cell differentiation animal organ development tissue development skin development keratinocyte differentiation regulation of epidermis development regulation of keratinocyte differentiation response to granulocyte macrophage colony-stimulating factor response to cytokine cellular response to granulocyte macrophage colony-stimulating factor stimulus cellular response to cytokine stimulus cellular response to tumor necrosis factor response to tumor necrosis factor regulation of molecular function regulation of catalytic activity negative regulation of transferase activity negative regulation of polynucleotide adenylyltransferase activity negative regulation of molecular function regulation of polynucleotide adenylyltransferase activity negative regulation of catalytic activity regulation of transferase activity viral gene expression regulation of viral process negative regulation of viral process regulation of viral transcription negative regulation of viral transcription viral process viral transcription cellular response to epidermal growth factor stimulus response to epidermal growth factor response to glucocorticoid cellular response to organic cyclic compound cellular response to glucocorticoid stimulus cellular response to corticosteroid stimulus response to corticosteroid response to hormone response to steroid hormone cellular response to steroid hormone stimulus response to organic cyclic compound cellular response to hormone stimulus regulation of epithelial cell apoptotic process regulation of apoptotic process regulation of programmed cell death cell death epithelial cell apoptotic process keratinocyte apoptotic process regulation of keratinocyte apoptotic process apoptotic process programmed cell death	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cytoplasmic ribonucleoprotein granule ribonucleoprotein granule intracellular organelle organelle intracellular non-membrane-bounded organelle supramolecular complex non-membrane-bounded organelle cytoplasmic stress granule CCR4-NOT complex protein-containing complex intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cytoplasmic ribonucleoprotein granule ribonucleoprotein granule intracellular organelle organelle intracellular non-membrane-bounded organelle supramolecular complex non-membrane-bounded organelle cytoplasmic stress granule CCR4-NOT complex protein-containing complex intracellular protein-containing complex P-body ribonucleoprotein complex membrane-bounded organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR024557	CCR4-NOT transcription complex subunit 1, domain 4	Domain
A	IPR032191	CCR4-NOT transcription complex subunit 1, CAF1-binding domain	Domain
A	IPR032193	CCR4-NOT transcription complex subunit 1, TTP binding domain	Domain
A	IPR038535	CCR4-NOT subunit 1, TTP binding domain superfamily	Homologous Superfamily
A	IPR040398	CCR4-NOT transcription complex subunit 1	Family
A	IPR007196	CCR4-Not complex component, Not1, C-terminal	Domain
A	IPR032194	CCR4-NOT transcription complex subunit 1, HEAT repeat	Domain
B	IPR000571	Zinc finger, CCCH-type	Domain
B	IPR036855	Zinc finger, CCCH-type superfamily	Homologous Superfamily
B	IPR045877	RNA-binding protein ZFP36-like	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: A5YKK6	atypical teratoid rhabdoid tumor large cell medulloblastoma osteosarcoma spina bifida autism spectrum disorder malignant ependymoma ovarian cancer holoprosencephaly medulloblastoma psoriasis
B	Pharos: P26651	alopecia arthritic joint disease hyperplasia Inflammation dermatitis lung adenocarcinoma malignant colon neoplasm medulloblastoma nephrosclerosis acute myeloid leukemia pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia transitional cell carcinoma breast carcinoma congestive heart failure lung cancer alopecia arthritic joint disease hyperplasia Inflammation dermatitis lung adenocarcinoma malignant colon neoplasm medulloblastoma nephrosclerosis acute myeloid leukemia pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia transitional cell carcinoma breast carcinoma congestive heart failure lung cancer malignant pancreatic neoplasm myocardial ischemia non-small cell lung carcinoma adenoma pituitary cancer psoriasis astrocytic tumor breast fibroadenoma coronary artery disease glioblastoma lung carcinoma MALT lymphoma pancreatic ductal adenocarcinoma adrenal cortex carcinoma androgenetic alopecia thrombotic thrombocytopenic purpura breast cancer hepatocellular carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.