Annotations: 4J80

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	DnaJ_C_C	e4j80A7	A: beta sandwiches	X: HSP40/DnaJ peptide-binding domain (From Topology)	H: HSP40/DnaJ peptide-binding domain (From Topology)	T: HSP40/DnaJ peptide-binding domain	F: DnaJ_C_C	ECOD (1.6)
A	DnaJ_C_N	e4j80A3	A: beta sandwiches	X: HSP40/DnaJ peptide-binding domain (From Topology)	H: HSP40/DnaJ peptide-binding domain (From Topology)	T: HSP40/DnaJ peptide-binding domain	F: DnaJ_C_N	ECOD (1.6)
A	DnaJ	e4j80A1	A: alpha bundles	X: Chaperone J-domain (From Topology)	H: Chaperone J-domain (From Topology)	T: Chaperone J-domain	F: DnaJ	ECOD (1.6)
C	DnaJ_C_C	e4j80C5	A: beta sandwiches	X: HSP40/DnaJ peptide-binding domain (From Topology)	H: HSP40/DnaJ peptide-binding domain (From Topology)	T: HSP40/DnaJ peptide-binding domain	F: DnaJ_C_C	ECOD (1.6)
C	DnaJ_C_N	e4j80C2	A: beta sandwiches	X: HSP40/DnaJ peptide-binding domain (From Topology)	H: HSP40/DnaJ peptide-binding domain (From Topology)	T: HSP40/DnaJ peptide-binding domain	F: DnaJ_C_N	ECOD (1.6)
C	DnaJ	e4j80C1	A: alpha bundles	X: Chaperone J-domain (From Topology)	H: Chaperone J-domain (From Topology)	T: Chaperone J-domain	F: DnaJ	ECOD (1.6)
D	DnaJ_C_C	e4j80D7	A: beta sandwiches	X: HSP40/DnaJ peptide-binding domain (From Topology)	H: HSP40/DnaJ peptide-binding domain (From Topology)	T: HSP40/DnaJ peptide-binding domain	F: DnaJ_C_C	ECOD (1.6)
D	DnaJ_C_N	e4j80D3	A: beta sandwiches	X: HSP40/DnaJ peptide-binding domain (From Topology)	H: HSP40/DnaJ peptide-binding domain (From Topology)	T: HSP40/DnaJ peptide-binding domain	F: DnaJ_C_N	ECOD (1.6)
D	DnaJ	e4j80D1	A: alpha bundles	X: Chaperone J-domain (From Topology)	H: Chaperone J-domain (From Topology)	T: Chaperone J-domain	F: DnaJ	ECOD (1.6)
B	DnaJ_C_C	e4j80B7	A: beta sandwiches	X: HSP40/DnaJ peptide-binding domain (From Topology)	H: HSP40/DnaJ peptide-binding domain (From Topology)	T: HSP40/DnaJ peptide-binding domain	F: DnaJ_C_C	ECOD (1.6)
B	DnaJ_C_N	e4j80B3	A: beta sandwiches	X: HSP40/DnaJ peptide-binding domain (From Topology)	H: HSP40/DnaJ peptide-binding domain (From Topology)	T: HSP40/DnaJ peptide-binding domain	F: DnaJ_C_N	ECOD (1.6)
B	DnaJ	e4j80B1	A: alpha bundles	X: Chaperone J-domain (From Topology)	H: Chaperone J-domain (From Topology)	T: Chaperone J-domain	F: DnaJ	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.287.110	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	DnaJ domain	CATH (4.3.0)
A	2.60.260.20	Mainly Beta	Sandwich	HSP40/DNAj peptide-binding domain	Urease metallochaperone UreE, N-terminal domain	CATH (4.3.0)
C	1.10.287.110	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	DnaJ domain	CATH (4.3.0)
C	2.60.260.20	Mainly Beta	Sandwich	HSP40/DNAj peptide-binding domain	Urease metallochaperone UreE, N-terminal domain	CATH (4.3.0)
D	1.10.287.110	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	DnaJ domain	CATH (4.3.0)
D	2.60.260.20	Mainly Beta	Sandwich	HSP40/DNAj peptide-binding domain	Urease metallochaperone UreE, N-terminal domain	CATH (4.3.0)
B	1.10.287.110	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	DnaJ domain	CATH (4.3.0)
B	2.60.260.20	Mainly Beta	Sandwich	HSP40/DNAj peptide-binding domain	Urease metallochaperone UreE, N-terminal domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00226	DnaJ domain (DnaJ)	DnaJ domain	DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is thought that this domain mediates the interaction. DnaJ-domain is therefore part of a chaperone (protein folding) system. The T-antigens, although not in Prosite are conf ...	DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is thought that this domain mediates the interaction. DnaJ-domain is therefore part of a chaperone (protein folding) system. The T-antigens, although not in Prosite are confirmed as DnaJ containing domains from literature [2].	Domain
A, B, C, D	PF01556	DnaJ C terminal domain (DnaJ_C)	DnaJ C terminal domain	This family consists of the C terminal region of the DnaJ protein. It is always found associated with Pfam:PF00226 and Pfam:PF00684. DnaJ is a chaperone associated with the Hsp70 heat-shock system involved in protein folding and renaturation after ...	This family consists of the C terminal region of the DnaJ protein. It is always found associated with Pfam:PF00226 and Pfam:PF00684. DnaJ is a chaperone associated with the Hsp70 heat-shock system involved in protein folding and renaturation after stress. The two C-terminal domains CTDI and CTDII, both incorporated in this family are necessary for maintaining the J-domains in their specific relative positions [2]. Structural analysis of PDB:1nlt shows that PF00684 is nested within this DnaJ C-terminal region [3].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Chaperone protein DnaJ 2	unfolded protein binding protein binding binding	nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process gene expression macromolecule biosynthetic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process gene expression macromolecule biosynthetic process protein maturation protein folding biosynthetic process organic substance biosynthetic process cellular process protein metabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR001623	DnaJ domain	Domain
A, B, C, D	IPR008971	HSP40/DnaJ peptide-binding	Homologous Superfamily
A, B, C, D	IPR018253	DnaJ domain, conserved site	Conserved Site
A, B, C, D	IPR002939	Chaperone DnaJ, C-terminal	Domain
A, B, C, D	IPR036869	Chaperone J-domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.