4J7B

Crystal structure of polo-like kinase 1

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4j7ba_	Alpha and beta proteins (a+b)	Protein kinase-like (PK-like)	Protein kinase-like (PK-like)	automated matches	automated matches	leopard danio,zebra danio,zebra fish (Danio rerio ) [TaxId: 7955 ],	SCOPe (2.08)
D	d4j7bd_	Alpha and beta proteins (a+b)	Protein kinase-like (PK-like)	Protein kinase-like (PK-like)	automated matches	automated matches	leopard danio,zebra danio,zebra fish (Danio rerio ) [TaxId: 7955 ],	SCOPe (2.08)
B	d4j7bb1	Alpha and beta proteins (a+b)	Polo-box domain	Polo-box domain	Polo-box duplicated region	Serine/threonine-protein kinase plk C-terminal domain	leopard danio,zebra danio,zebra fish (Danio rerio ) [TaxId: 7955 ],	SCOPe (2.08)
E	d4j7be1	Alpha and beta proteins (a+b)	Polo-box domain	Polo-box domain	Polo-box duplicated region	Serine/threonine-protein kinase plk C-terminal domain	leopard danio,zebra danio,zebra fish (Danio rerio ) [TaxId: 7955 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Protein kinase-like (PK-like)	8062408	3000066	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Protein kinase-like (PK-like)	8062408	3000066	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00069	e4j7bA1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: PF00069	ECOD (1.6)
D	PF00069	e4j7bD1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: PF00069	ECOD (1.6)
B	PF00659	e4j7bB1	A: a+b two layers	X: RIP/Polo-box domain	H: Polo-box domain (From Topology)	T: Polo-box domain	F: PF00659	ECOD (1.6)
E	PF00659	e4j7bE1	A: a+b two layers	X: RIP/Polo-box domain	H: Polo-box domain (From Topology)	T: Polo-box domain	F: PF00659	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.200.20	Alpha Beta	2-Layer Sandwich	Phosphorylase Kinase	domain 1	CATH (4.3.0)
A	1.10.510.10	Mainly Alpha	Orthogonal Bundle	Transferase(Phosphotransferase)	domain 1	CATH (4.3.0)
D	3.30.200.20	Alpha Beta	2-Layer Sandwich	Phosphorylase Kinase	domain 1	CATH (4.3.0)
D	1.10.510.10	Mainly Alpha	Orthogonal Bundle	Transferase(Phosphotransferase)	domain 1	CATH (4.3.0)
B	3.30.1120.30	Alpha Beta	2-Layer Sandwich	Arylsulfatase, C-terminal domain	POLO box domain	CATH (4.3.0)
E	3.30.1120.30	Alpha Beta	2-Layer Sandwich	Arylsulfatase, C-terminal domain	POLO box domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, D	PF00069	Protein kinase domain (Pkinase)	Protein kinase domain	-	Domain
B, E	PF00659	POLO box duplicated region (POLO_box)	POLO box duplicated region	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, D	Polo-like kinase	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups	cellular process cell cycle mitotic cell cycle cell division developmental process multicellular organismal process sensory organ development eye development animal organ development retina development in camera-type eye visual system development multicellular organism development camera-type eye development anatomical structure development cellular process cell cycle mitotic cell cycle cell division developmental process multicellular organismal process sensory organ development eye development animal organ development retina development in camera-type eye visual system development multicellular organism development camera-type eye development anatomical structure development sensory system development system development microtubule cytoskeleton organization mitotic spindle organization cellular component organization organelle organization mitotic cell cycle process microtubule-based process cellular component organization or biogenesis cytoskeleton organization microtubule cytoskeleton organization involved in mitosis spindle organization cell cycle process phosphorylation cellular metabolic process phosphate-containing compound metabolic process metabolic process phosphorus metabolic process	midbody cellular anatomical entity intracellular organelle intracellular anatomical structure cytoskeleton spindle organelle intracellular non-membrane-bounded organelle spindle pole microtubule cytoskeleton non-membrane-bounded organelle chromosome chromosomal region kinetochore midbody cellular anatomical entity intracellular organelle intracellular anatomical structure cytoskeleton spindle organelle intracellular non-membrane-bounded organelle spindle pole microtubule cytoskeleton non-membrane-bounded organelle chromosome chromosomal region kinetochore chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome centrosome microtubule organizing center cytoplasm membrane-bounded organelle nucleus intracellular membrane-bounded organelle
B, E	Polo-like kinase	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups	cellular process cell cycle mitotic cell cycle cell division developmental process multicellular organismal process sensory organ development eye development animal organ development retina development in camera-type eye visual system development multicellular organism development camera-type eye development anatomical structure development cellular process cell cycle mitotic cell cycle cell division developmental process multicellular organismal process sensory organ development eye development animal organ development retina development in camera-type eye visual system development multicellular organism development camera-type eye development anatomical structure development sensory system development system development microtubule cytoskeleton organization mitotic spindle organization cellular component organization organelle organization mitotic cell cycle process microtubule-based process cellular component organization or biogenesis cytoskeleton organization microtubule cytoskeleton organization involved in mitosis spindle organization cell cycle process phosphorylation cellular metabolic process phosphate-containing compound metabolic process metabolic process phosphorus metabolic process	midbody cellular anatomical entity intracellular organelle intracellular anatomical structure cytoskeleton spindle organelle intracellular non-membrane-bounded organelle spindle pole microtubule cytoskeleton non-membrane-bounded organelle chromosome chromosomal region kinetochore midbody cellular anatomical entity intracellular organelle intracellular anatomical structure cytoskeleton spindle organelle intracellular non-membrane-bounded organelle spindle pole microtubule cytoskeleton non-membrane-bounded organelle chromosome chromosomal region kinetochore chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome centrosome microtubule organizing center cytoplasm membrane-bounded organelle nucleus intracellular membrane-bounded organelle
C, F	205 kDa microtubule-associated protein	-	cellular process cell cycle mitotic cell cycle microtubule organizing center organization microtubule cytoskeleton organization cellular component organization organelle organization centrosome cycle microtubule-based process cellular component organization or biogenesis cytoskeleton organization cell cycle process	midbody cellular anatomical entity intracellular organelle intracellular anatomical structure cytoskeleton spindle organelle intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle protein-containing complex microtubule associated complex cytoplasm polymeric cytoskeletal fiber midbody cellular anatomical entity intracellular organelle intracellular anatomical structure cytoskeleton spindle organelle intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle protein-containing complex microtubule associated complex cytoplasm polymeric cytoskeletal fiber supramolecular fiber microtubule supramolecular polymer supramolecular complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, D	IPR033695	Second polo-box domain	Domain
A, D	IPR017441	Protein kinase, ATP binding site	Binding Site
A, D	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A, D	IPR036947	POLO box domain superfamily	Homologous Superfamily
A, D	IPR000719	Protein kinase domain	Domain
A, D	IPR000959	POLO box domain	Domain
A, D	IPR033701	First polo-box domain	Domain
A, D	IPR033702	Polo-like kinase 1, catalytic domain	Domain
A, D	IPR008271	Serine/threonine-protein kinase, active site	Active Site
B, E	IPR033695	Second polo-box domain	Domain
B, E	IPR017441	Protein kinase, ATP binding site	Binding Site
B, E	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
B, E	IPR036947	POLO box domain superfamily	Homologous Superfamily
B, E	IPR000719	Protein kinase domain	Domain
B, E	IPR000959	POLO box domain	Domain
B, E	IPR033701	First polo-box domain	Domain
B, E	IPR033702	Polo-like kinase 1, catalytic domain	Domain
B, E	IPR008271	Serine/threonine-protein kinase, active site	Active Site

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.