Annotations: 4J00

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Homeodomain-like	8055694	3000001	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Winged helix DNA-binding domain	8055695	3000034	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	HetR C-terminal hood domain	8055696	3002297	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	HetR C-terminal hood domain	8055696	3002297	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Homeodomain-like	8055694	3000001	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Winged helix DNA-binding domain	8055695	3000034	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF03574	e4j00A1	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: PF03574	ECOD (1.6)
A	PF03574	e4j00A3	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF03574	ECOD (1.6)
A	PF18460	e4j00A2	A: a+b duplicates or obligate multimers	X: Dimerization domain of heterocyst differentiation protein HetR (From Topology)	H: Dimerization domain of heterocyst differentiation protein HetR (From Topology)	T: Dimerization domain of heterocyst differentiation protein HetR	F: PF18460	ECOD (1.6)
B	PF03574	e4j00B1	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: PF03574	ECOD (1.6)
B	PF03574	e4j00B2	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF03574	ECOD (1.6)
B	PF18460	e4j00B3	A: a+b duplicates or obligate multimers	X: Dimerization domain of heterocyst differentiation protein HetR (From Topology)	H: Dimerization domain of heterocyst differentiation protein HetR (From Topology)	T: Dimerization domain of heterocyst differentiation protein HetR	F: PF18460	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.10.1680	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	HetR, N-terminal DNA-binding domain	CATH (4.3.0)
A	1.10.10.1670	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	HetR, flap domain	CATH (4.3.0)
B	1.10.10.1680	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	HetR, N-terminal DNA-binding domain	CATH (4.3.0)
B	1.10.10.1670	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	HetR, flap domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF18460	Heterocyst differentiation regulator C-terminal Hood domain (HetR_C)	Heterocyst differentiation regulator C-terminal Hood domain	This is the C-terminal hood domain found in Heterocyst differentiation control protein (HetR). HetR-C binds to PatS peptide. Two PatS6 peptides bind to the lateral clefts of HetR-Hood domain, and trigger significant conformational changes of the flap ...	This is the C-terminal hood domain found in Heterocyst differentiation control protein (HetR). HetR-C binds to PatS peptide. Two PatS6 peptides bind to the lateral clefts of HetR-Hood domain, and trigger significant conformational changes of the flap domain, resulting in dissociation of the auxiliary alpha-helix and eventually release of HetR from the DNA major grove and termination of transcription [1].	Domain
A, B	PF03574	Peptidase family S48 (Peptidase_S48)	Peptidase family S48	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Transcription Factor HetR	DNA binding binding organic cyclic compound binding nucleic acid binding peptidase activity catalytic activity, acting on a protein serine hydrolase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity catalytic activity endopeptidase activity	developmental process heterocyst development cellular developmental process cellular process organic substance metabolic process organonitrogen compound metabolic process proteolysis metabolic process primary metabolic process protein metabolic process macromolecule metabolic process	-
C, D	DNA (5'-D(TPGPGPTPGPAPGPGPGPGPTPTPAPAPAPCPCPCPCPTPCPAPCPC)-3')	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR041935	HetR, flap domain	Homologous Superfamily
A, B	IPR041936	HetR, N-terminal DNA-binding domain	Homologous Superfamily
A, B	IPR005319	Peptidase S48, DNA-binding transcriptional activator HetR	Family
A, B	IPR040949	HetR, C-terminal Hood domain	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.