Annotations: 4IMP

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF18369	e4impA1	A: alpha duplicates or obligate multimers	X: Dimerization element domain in modular polyketide synthases (From Topology)	H: Dimerization element domain in modular polyketide synthases (From Topology)	T: Dimerization element domain in modular polyketide synthases	F: PF18369	ECOD (1.6)
A	F_UNCLASSIFIED	e4impA3	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: F_UNCLASSIFIED	ECOD (1.6)
A	PF08659	e4impA2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF08659	ECOD (1.6)
B	PF18369	e4impB1	A: alpha duplicates or obligate multimers	X: Dimerization element domain in modular polyketide synthases (From Topology)	H: Dimerization element domain in modular polyketide synthases (From Topology)	T: Dimerization element domain in modular polyketide synthases	F: PF18369	ECOD (1.6)
B	F_UNCLASSIFIED	e4impB2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: F_UNCLASSIFIED	ECOD (1.6)
B	PF08659	e4impB3	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF08659	ECOD (1.6)
C	PF18369	e4impC6	A: alpha duplicates or obligate multimers	X: Dimerization element domain in modular polyketide synthases (From Topology)	H: Dimerization element domain in modular polyketide synthases (From Topology)	T: Dimerization element domain in modular polyketide synthases	F: PF18369	ECOD (1.6)
C	F_UNCLASSIFIED	e4impC4	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: F_UNCLASSIFIED	ECOD (1.6)
C	PF08659	e4impC5	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF08659	ECOD (1.6)
D	PF18369	e4impD6	A: alpha duplicates or obligate multimers	X: Dimerization element domain in modular polyketide synthases (From Topology)	H: Dimerization element domain in modular polyketide synthases (From Topology)	T: Dimerization element domain in modular polyketide synthases	F: PF18369	ECOD (1.6)
D	F_UNCLASSIFIED	e4impD4	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: F_UNCLASSIFIED	ECOD (1.6)
D	PF08659	e4impD5	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF08659	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	6.10.140.1830	Special	Helix non-globular	Helix Hairpins		CATH (4.3.0)
A	3.40.50.11460	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
A	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)
B	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)
C	6.10.140.1830	Special	Helix non-globular	Helix Hairpins		CATH (4.3.0)
C	3.40.50.11460	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
C	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)
D	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF08659	KR domain (KR)	KR domain	-	Family
A, B, C, D	PF18369	Polyketide synthase dimerisation element domain (PKS_DE)	Polyketide synthase dimerisation element domain	This is the dimerisation element domain found in bacterial modular polyketide synthase ketoreductases [1]. The dimerization element (DE) domain is N-terminal to the KR domain Pfam:PF08659. DE domain is necessary for KR function, presumably because th ...	This is the dimerisation element domain found in bacterial modular polyketide synthase ketoreductases [1]. The dimerization element (DE) domain is N-terminal to the KR domain Pfam:PF08659. DE domain is necessary for KR function, presumably because the dimeric DE orients the KR domains for optimal activity within a module [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Polyketide synthase extender modules 3-4	binding nucleoside phosphate binding organic cyclic compound binding nucleotide binding heterocyclic compound binding small molecule binding vitamin binding amide binding modified amino acid binding phosphopantetheine binding acyltransferase activity 3-oxoacyl-[acyl-carrier-protein] synthase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity binding nucleoside phosphate binding organic cyclic compound binding nucleotide binding heterocyclic compound binding small molecule binding vitamin binding amide binding modified amino acid binding phosphopantetheine binding acyltransferase activity 3-oxoacyl-[acyl-carrier-protein] synthase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity catalytic activity	fatty acid metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process oxoacid metabolic process cellular biosynthetic process cellular metabolic process carboxylic acid metabolic process lipid biosynthetic process primary metabolic process organic acid biosynthetic process organic acid metabolic process fatty acid biosynthetic process carboxylic acid biosynthetic process organic substance metabolic process biosynthetic process fatty acid metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process oxoacid metabolic process cellular biosynthetic process cellular metabolic process carboxylic acid metabolic process lipid biosynthetic process primary metabolic process organic acid biosynthetic process organic acid metabolic process fatty acid biosynthetic process carboxylic acid biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process cellular lipid metabolic process small molecule metabolic process metabolic process cellular process monocarboxylic acid metabolic process lipid metabolic process macrolide biosynthetic process polyketide metabolic process macrolide metabolic process secondary metabolic process antibiotic biosynthetic process organic cyclic compound metabolic process antibiotic metabolic process polyketide biosynthetic process secondary metabolite biosynthetic process lactone metabolic process lactone biosynthetic process organic cyclic compound biosynthetic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR041618	Polyketide synthase dimerisation element domain	Domain
A, B, C, D	IPR016035	Acyl transferase/acyl hydrolase/lysophospholipase	Homologous Superfamily
A, B, C, D	IPR014031	Beta-ketoacyl synthase, C-terminal	Domain
A, B, C, D	IPR006162	Phosphopantetheine attachment site	PTM
A, B, C, D	IPR015083	Polyketide synthase, docking domain	Domain
A, B, C, D	IPR032821	Polyketide synthase, C-terminal extension	Domain
A, B, C, D	IPR009081	Phosphopantetheine binding ACP domain	Domain
A, B, C, D	IPR014030	Beta-ketoacyl synthase, N-terminal	Domain
A, B, C, D	IPR036299	Polyketide synthase, docking domain superfmaily	Homologous Superfamily
A, B, C, D	IPR013968	Polyketide synthase, ketoreductase domain	Domain
A, B, C, D	IPR016039	Thiolase-like	Homologous Superfamily
A, B, C, D	IPR001227	Acyl transferase domain superfamily	Homologous Superfamily
A, B, C, D	IPR016036	Malonyl-CoA ACP transacylase, ACP-binding	Homologous Superfamily
A, B, C, D	IPR036291	NAD(P)-binding domain superfamily	Homologous Superfamily
A, B, C, D	IPR020806	Polyketide synthase, phosphopantetheine-binding domain	Domain
A, B, C, D	IPR014043	Acyl transferase	Domain
A, B, C, D	IPR018201	Beta-ketoacyl synthase, active site	Active Site
A, B, C, D	IPR020841	Polyketide synthase, beta-ketoacyl synthase domain	Domain
A, B, C, D	IPR036736	ACP-like superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.