4IM8

low resolution crystal structure of mouse RAGE

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF08205	e4im8A2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF08205	ECOD (1.6)
A	PF13895	e4im8A1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF13895	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00047	Immunoglobulin domain (ig)	Immunoglobulin domain	Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-prot ...	Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.	Domain
A	PF08205	CD80-like C2-set immunoglobulin domain (C2-set_2)	CD80-like C2-set immunoglobulin domain	These domains belong to the immunoglobulin superfamily.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Advanced glycation end-products receptor	amide binding amyloid-beta binding binding peptide binding cell adhesion molecule binding laminin receptor activity protein binding cell adhesion mediator activity protein-containing complex binding molecular adaptor activity identical protein binding molecular transducer activity signaling receptor activity high mobility group box 1 binding amide binding amyloid-beta binding binding peptide binding cell adhesion molecule binding laminin receptor activity protein binding cell adhesion mediator activity protein-containing complex binding molecular adaptor activity identical protein binding molecular transducer activity signaling receptor activity high mobility group box 1 binding cytokine binding S100 protein binding	negative regulation of long-term synaptic potentiation positive regulation of cell communication regulation of cellular process modulation of chemical synaptic transmission signaling positive regulation of biological process negative regulation of biological process cell communication long-term synaptic potentiation synaptic signaling regulation of biological quality positive regulation of cellular process regulation of synaptic plasticity trans-synaptic signaling negative regulation of long-term synaptic potentiation positive regulation of cell communication regulation of cellular process modulation of chemical synaptic transmission signaling positive regulation of biological process negative regulation of biological process cell communication long-term synaptic potentiation synaptic signaling regulation of biological quality positive regulation of cellular process regulation of synaptic plasticity trans-synaptic signaling regulation of biological process regulation of signaling biological regulation cell-cell signaling positive regulation of synaptic transmission chemical synaptic transmission regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of long-term synaptic potentiation regulation of cell communication cellular process positive regulation of signaling positive regulation of locomotion regulation of cell motility positive regulation of monocyte extravasation positive regulation of cell migration monocyte extravasation positive regulation of cell motility cellular extravasation myeloid leukocyte migration regulation of cell migration positive regulation of mononuclear cell migration cell migration regulation of immune system process cell motility regulation of mononuclear cell migration positive regulation of immune system process locomotion regulation of leukocyte migration positive regulation of leukocyte migration leukocyte migration immune system process regulation of locomotion mononuclear cell migration regulation of monocyte extravasation regulation of cellular extravasation positive regulation of cellular extravasation regulation of biosynthetic process negative regulation of collagen metabolic process negative regulation of metabolic process collagen biosynthetic process regulation of collagen biosynthetic process regulation of collagen metabolic process negative regulation of collagen biosynthetic process biosynthetic process negative regulation of biosynthetic process metabolic process collagen metabolic process regulation of metabolic process cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process organic substance metabolic process positive regulation of biosynthetic process organic substance biosynthetic process positive regulation of macromolecule metabolic process cellular metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression positive regulation of gene expression regulation of macromolecule biosynthetic process macromolecule metabolic process positive regulation of cellular biosynthetic process regulation of protein modification process regulation of protein phosphorylation negative regulation of phosphate metabolic process negative regulation of cellular metabolic process regulation of primary metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process negative regulation of protein modification process negative regulation of cellular process protein metabolic process protein modification process phosphorus metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process organonitrogen compound metabolic process protein phosphorylation phosphorylation regulation of protein metabolic process primary metabolic process negative regulation of protein phosphorylation macromolecule modification negative regulation of phosphorus metabolic process regulation of phosphorylation regulation of phosphorus metabolic process negative regulation of phosphorylation positive regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death positive regulation of apoptotic process apoptotic process programmed cell death neuron apoptotic process positive regulation of neuron apoptotic process regulation of neuron apoptotic process positive regulation of epithelial cell apoptotic process regulation of epithelial cell apoptotic process regulation of type B pancreatic cell apoptotic process epithelial cell apoptotic process positive regulation of type B pancreatic cell apoptotic process type B pancreatic cell apoptotic process positive regulation of smooth muscle cell migration regulation of smooth muscle cell migration smooth muscle cell migration muscle cell migration regulation of leukocyte differentiation multicellular organismal process cellular developmental process regulation of developmental process cell development mononuclear cell differentiation regulation of cell differentiation regulation of cell development positive regulation of developmental process multicellular organism development positive regulation of hemopoiesis positive regulation of cell differentiation cell differentiation anatomical structure development regulation of multicellular organismal process developmental process regulation of multicellular organismal development hemopoiesis positive regulation of cell development regulation of dendritic cell differentiation regulation of hemopoiesis positive regulation of multicellular organismal process dendritic cell differentiation positive regulation of leukocyte differentiation positive regulation of dendritic cell differentiation leukocyte differentiation astrocyte differentiation nervous system development glial cell development neurogenesis astrocyte development central nervous system development gliogenesis glial cell differentiation system development interleukin-1 production regulation of interleukin-1 beta production positive regulation of interleukin-1 beta production regulation of cytokine production cytokine production positive regulation of interleukin-1 production regulation of interleukin-1 production interleukin-1 beta production positive regulation of cytokine production adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of immune effector process lymphocyte mediated immunity T cell mediated immunity response to stimulus regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains leukocyte mediated immunity regulation of T cell mediated immunity T cell mediated cytotoxicity immune response regulation of adaptive immune response regulation of leukocyte mediated cytotoxicity leukocyte mediated cytotoxicity adaptive immune response immune effector process regulation of T cell mediated cytotoxicity regulation of leukocyte mediated immunity regulation of lymphocyte mediated immunity regulation of response to stimulus regulation of immune response regulation of cell killing cell killing cellular response to stimulus positive regulation of signal transduction regulation of signal transduction intracellular signal transduction positive regulation of response to stimulus positive regulation of JNK cascade regulation of intracellular signal transduction JNK cascade intracellular signaling cassette signal transduction positive regulation of MAPK cascade regulation of JNK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade MAPK cascade regulation of chemokine production chemokine production positive regulation of chemokine production astrocyte activation response to stress defense response cell activation glial cell activation inflammatory response neuroinflammatory response protein localization localization cellular localization cellular macromolecule localization macromolecule localization localization within membrane protein localization to membrane cell population proliferation regulation of smooth muscle cell proliferation positive regulation of cell population proliferation smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation regulation of cell population proliferation muscle cell proliferation response to decreased oxygen levels response to hypoxia response to oxygen levels response to abiotic stimulus positive regulation of cell adhesion regulation of cell adhesion positive regulation of cell-cell adhesion heterotypic cell-cell adhesion cell adhesion cell-cell adhesion positive regulation of heterotypic cell-cell adhesion regulation of cell-cell adhesion regulation of heterotypic cell-cell adhesion system process circulatory system process transport vascular process in circulatory system vascular transport establishment of localization transport across blood-brain barrier positive regulation of autophagy catabolic process autophagy regulation of catabolic process regulation of autophagy cellular catabolic process positive regulation of catabolic process regulation of cellular catabolic process positive regulation of cellular catabolic process process utilizing autophagic mechanism regulation of alpha-beta T cell activation regulation of leukocyte activation regulation of cell activation regulation of T cell activation lymphocyte activation leukocyte activation regulation of CD4-positive, alpha-beta T cell activation T cell activation CD4-positive, alpha-beta T cell activation alpha-beta T cell activation regulation of lymphocyte activation myeloid leukocyte activation macrophage activation leukocyte activation involved in inflammatory response microglial cell activation plasma membrane bounded cell projection organization cell projection organization neuron projection development cellular component organization generation of neurons neuron differentiation neuron development cellular component organization or biogenesis regulation of endothelin production positive regulation of endothelin production endothelin production negative regulation of cell adhesion hexose mediated signaling response to organic substance homeostatic process response to monosaccharide response to carbohydrate carbohydrate homeostasis cellular response to hexose stimulus intracellular chemical homeostasis cellular response to monosaccharide stimulus cellular response to organic substance response to oxygen-containing compound cellular response to glucose stimulus intracellular glucose homeostasis cellular response to oxygen-containing compound response to hexose sugar mediated signaling pathway glucose mediated signaling pathway cellular response to carbohydrate stimulus cellular response to chemical stimulus cellular homeostasis chemical homeostasis response to glucose response to chemical glucose homeostasis carbohydrate mediated signaling positive chemotaxis chemotaxis regulation of response to external stimulus positive regulation of positive chemotaxis response to external stimulus induction of positive chemotaxis regulation of chemotaxis positive regulation of chemotaxis regulation of positive chemotaxis positive regulation of response to external stimulus taxis positive regulation of ERK1 and ERK2 cascade ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade import into cell regulation of localization regulation of cellular component organization positive regulation of cellular component organization positive regulation of membrane invagination vesicle-mediated transport positive regulation of endocytosis regulation of phagocytosis, engulfment membrane invagination phagocytosis plasma membrane invagination regulation of endocytosis membrane organization regulation of transport regulation of phagocytosis regulation of vesicle-mediated transport phagocytosis, engulfment positive regulation of phagocytosis positive regulation of transport positive regulation of phagocytosis, engulfment regulation of membrane invagination endocytosis regulation of epithelial to mesenchymal transition positive regulation of epithelial to mesenchymal transition mesenchyme development animal organ development tissue development epithelial to mesenchymal transition mesenchymal cell differentiation interleukin-6 production positive regulation of interleukin-6 production regulation of interleukin-6 production fibroblast proliferation regulation of fibroblast proliferation positive regulation of fibroblast proliferation regulation of fibroblast migration positive regulation of fibroblast migration fibroblast migration ameboidal-type cell migration spontaneous synaptic transmission regulation of spontaneous synaptic transmission regulation of interleukin-12 production interleukin-12 production positive regulation of interleukin-12 production regulation of monocyte chemotactic protein-1 production positive regulation of monocyte chemotactic protein-1 production monocyte chemotactic protein-1 production negative regulation of interleukin-10 production interleukin-10 production regulation of interleukin-10 production negative regulation of cytokine production negative regulation of cellular biosynthetic process negative regulation of gene expression negative regulation of macromolecule biosynthetic process negative regulation of multicellular organismal process reactive oxygen species metabolic process positive regulation of reactive oxygen species metabolic process regulation of reactive oxygen species metabolic process response to organonitrogen compound response to nitrogen compound response to amyloid-beta positive regulation of cell activation lymphocyte proliferation positive regulation of leukocyte activation regulation of leukocyte proliferation positive regulation of T cell activation positive regulation of lymphocyte proliferation positive regulation of T cell proliferation positive regulation of activated T cell proliferation mononuclear cell proliferation regulation of leukocyte cell-cell adhesion positive regulation of leukocyte proliferation regulation of activated T cell proliferation positive regulation of leukocyte cell-cell adhesion leukocyte proliferation leukocyte cell-cell adhesion activated T cell proliferation positive regulation of lymphocyte activation positive regulation of mononuclear cell proliferation T cell proliferation regulation of lymphocyte proliferation regulation of T cell proliferation regulation of mononuclear cell proliferation regulation of defense response regulation of inflammatory response regulation of response to stress p38MAPK cascade regulation of p38MAPK cascade transcytosis negative regulation of locomotion endothelial cell migration negative regulation of endothelial cell migration tissue migration negative regulation of epithelial cell migration regulation of endothelial cell migration epithelial cell migration regulation of epithelial cell migration negative regulation of cell migration epithelium migration negative regulation of cell motility regulation of system process negative regulation of blood circulation regulation of blood circulation blood circulation behavior learning or memory nervous system process cognition negative regulation of signaling negative regulation of synaptic transmission negative regulation of cell communication negative regulation of long-term synaptic depression long-term synaptic depression regulation of long-term synaptic depression positive regulation of endothelial cell apoptotic process endothelial cell apoptotic process regulation of endothelial cell apoptotic process regulation of non-canonical NF-kappaB signal transduction non-canonical NF-kappaB signal transduction positive regulation of non-canonical NF-kappaB signal transduction positive regulation of p38MAPK cascade positive regulation of phosphorylation positive regulation of protein metabolic process positive regulation of phosphate metabolic process positive regulation of protein modification process positive regulation of protein phosphorylation positive regulation of phosphorus metabolic process cell surface receptor signaling pathway via STAT cell surface receptor signaling pathway cell surface receptor signaling pathway via JAK-STAT regulation of tumor necrosis factor production positive regulation of tumor necrosis factor superfamily cytokine production tumor necrosis factor superfamily cytokine production positive regulation of tumor necrosis factor production tumor necrosis factor production regulation of tumor necrosis factor superfamily cytokine production cellular response to nitrogen compound response to endogenous stimulus cellular response to amyloid-beta cellular response to endogenous stimulus cellular response to organonitrogen compound negative regulation of cell population proliferation endothelial cell proliferation negative regulation of endothelial cell proliferation regulation of endothelial cell proliferation regulation of epithelial cell proliferation epithelial cell proliferation negative regulation of epithelial cell proliferation	somatodendritic compartment cell body neuronal cell body cellular anatomical entity axon cell projection neuron projection plasma membrane bounded cell projection extracellular region extracellular space cell junction cell periphery apical part of cell membrane somatodendritic compartment cell body neuronal cell body cellular anatomical entity axon cell projection neuron projection plasma membrane bounded cell projection extracellular region extracellular space cell junction cell periphery apical part of cell membrane plasma membrane plasma membrane region apical plasma membrane basal part of cell basal plasma membrane cell surface membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen fibrillar center organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A	IPR003006	Immunoglobulin/major histocompatibility complex, conserved site	Conserved Site
A	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A	IPR013151	Immunoglobulin	Domain
A	IPR007110	Immunoglobulin-like domain	Domain
A	IPR003599	Immunoglobulin subtype	Domain
A	IPR003598	Immunoglobulin subtype 2	Domain
A	IPR013162	CD80-like, immunoglobulin C2-set	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.