Annotations: 4IIK

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF21511	e4iikA1	A: a+b four layers	X: Ntn/PP2C	H: Protein serine/threonine phosphatase 2C, catalytic domain (From Topology)	T: Protein serine/threonine phosphatase 2C, catalytic domain	F: PF21511	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.60.40.20	Alpha Beta	4-Layer Sandwich	Phosphatase 2c	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF21511	SidD, catalytic domain (SidD_cat)	SidD, catalytic domain	SidD from Legionella pneumophila is a virulence effector that plays a role in hijacking the host vesicular trafficking by recruiting the small guanosine triphosphatase (GTPase) Rab1 to the cytosolic face of the Legionella-containing vacuole (LCVs). T ...	SidD from Legionella pneumophila is a virulence effector that plays a role in hijacking the host vesicular trafficking by recruiting the small guanosine triphosphatase (GTPase) Rab1 to the cytosolic face of the Legionella-containing vacuole (LCVs). This entry represents the catalytic domain [1,2].	Domain
A	PF21513	SidD, C-terminal (SidD_C)	SidD, C-terminal	SidD from Legionella pneumophila is a virulence effector that plays a role in hijacking the host vesicular trafficking by recruiting the small guanosine triphosphatase (GTPase) Rab1 to the cytosolic face of the Legionella-containing vacuole (LCVs). T ...	SidD from Legionella pneumophila is a virulence effector that plays a role in hijacking the host vesicular trafficking by recruiting the small guanosine triphosphatase (GTPase) Rab1 to the cytosolic face of the Legionella-containing vacuole (LCVs). This entry represents the C-terminal helical domain, which targets SidD to the Golgi and critical for membrane localization within host cells [1,2]. A two-helix bundle at the very C-terminal determines SidD specificity [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Adenosine monophosphate-protein hydrolase SidD	small GTPase binding protein binding binding enzyme binding GTPase binding cation binding ion binding metal ion binding small molecule binding phosphoric ester hydrolase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds phosphoric diester hydrolase activity protein adenylylhydrolase activity small GTPase binding protein binding binding enzyme binding GTPase binding cation binding ion binding metal ion binding small molecule binding phosphoric ester hydrolase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds phosphoric diester hydrolase activity protein adenylylhydrolase activity hydrolase activity catalytic activity	regulation of molecular function regulation of catalytic activity regulation of hydrolase activity biological regulation regulation of GTPase activity organic substance metabolic process organonitrogen compound metabolic process protein denucleotidylation macromolecule modification protein deadenylylation metabolic process primary metabolic process protein metabolic process macromolecule metabolic process regulation of molecular function regulation of catalytic activity regulation of hydrolase activity biological regulation regulation of GTPase activity organic substance metabolic process organonitrogen compound metabolic process protein denucleotidylation macromolecule modification protein deadenylylation metabolic process primary metabolic process protein metabolic process macromolecule metabolic process protein modification process protein nucleotidylation protein adenylylation	host cellular component host intracellular part host cell perinuclear region of cytoplasm host cell cytoplasm host cell part host intracellular region cellular anatomical entity host cell cytoplasm part

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR048704	SidD, catalytic domain	Domain
A	IPR048702	SidD, C-terminal domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.