Annotations: 4IGG

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	alpha-Catenin/Vinculin-like	8032950	3001619	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	alpha-Catenin/Vinculin-like	8032949	3001619	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	alpha-Catenin/Vinculin-like	8032949	3001619	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	alpha-Catenin/Vinculin-like	8032950	3001619	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Vinculin_1st	e4iggA1	A: alpha bundles	X: Four-helical up-and-down bundle	H: alpha-catenin-related	T: alpha-catenin/vinculin	F: Vinculin_1st	ECOD (1.6)
A	Vinculin_2nd	e4iggA4	A: alpha bundles	X: Four-helical up-and-down bundle	H: alpha-catenin-related	T: alpha-catenin/vinculin	F: Vinculin_2nd	ECOD (1.6)
B	Vinculin_1st	e4iggB8	A: alpha bundles	X: Four-helical up-and-down bundle	H: alpha-catenin-related	T: alpha-catenin/vinculin	F: Vinculin_1st	ECOD (1.6)
B	Vinculin_2nd	e4iggB3	A: alpha bundles	X: Four-helical up-and-down bundle	H: alpha-catenin-related	T: alpha-catenin/vinculin	F: Vinculin_2nd	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.287.160	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	HR1 repeat	CATH (4.3.0)
A	1.20.120.230	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)	Alpha-catenin/vinculin-like	CATH (4.3.0)
B	1.10.287.160	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	HR1 repeat	CATH (4.3.0)
B	1.20.120.230	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)	Alpha-catenin/vinculin-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF01044	Vinculin family (Vinculin)	Vinculin family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Catenin alpha-1	cytoskeletal protein binding actin binding protein-containing complex binding protein binding binding actin filament binding cell adhesion molecule binding cadherin binding identical protein binding gamma-catenin binding vinculin binding RNA binding organic cyclic compound binding nucleic acid binding cytoskeletal protein binding actin binding protein-containing complex binding protein binding binding actin filament binding cell adhesion molecule binding cadherin binding identical protein binding gamma-catenin binding vinculin binding RNA binding organic cyclic compound binding nucleic acid binding structural molecule activity beta-catenin binding	developmental process multicellular organismal process gonad development reproductive system development reproductive process sex differentiation animal organ development developmental process involved in reproduction male gonad development male sex differentiation multicellular organism development development of primary male sexual characteristics development of primary sexual characteristics anatomical structure development reproductive structure development developmental process multicellular organismal process gonad development reproductive system development reproductive process sex differentiation animal organ development developmental process involved in reproduction male gonad development male sex differentiation multicellular organism development development of primary male sexual characteristics development of primary sexual characteristics anatomical structure development reproductive structure development system development neuroblast proliferation cell population proliferation cellular developmental process nervous system development generation of neurons neurogenesis cell differentiation cellular process neural precursor cell proliferation protein localization localization cellular localization cellular macromolecule localization macromolecule localization cell adhesion cell-cell adhesion epithelial cell-cell adhesion cellular response to stimulus regulation of integrin-mediated signaling pathway regulation of cellular process response to stimulus signaling negative regulation of signaling negative regulation of biological process regulation of signal transduction negative regulation of cell communication cell communication negative regulation of integrin-mediated signaling pathway negative regulation of cellular process signal transduction regulation of biological process regulation of signaling integrin-mediated signaling pathway cell surface receptor signaling pathway negative regulation of response to stimulus biological regulation negative regulation of signal transduction regulation of response to stimulus regulation of cell communication positive regulation of cell communication positive regulation of signal transduction signal transduction in absence of ligand positive regulation of biological process regulation of programmed cell death positive regulation of extrinsic apoptotic signaling pathway in absence of ligand extrinsic apoptotic signaling pathway positive regulation of apoptotic signaling pathway positive regulation of response to stimulus extrinsic apoptotic signaling pathway in absence of ligand positive regulation of cellular process positive regulation of programmed cell death regulation of apoptotic process positive regulation of extrinsic apoptotic signaling pathway cell death positive regulation of apoptotic process regulation of extrinsic apoptotic signaling pathway apoptotic signaling pathway regulation of extrinsic apoptotic signaling pathway in absence of ligand apoptotic process programmed cell death regulation of apoptotic signaling pathway positive regulation of signaling negative regulation of neural precursor cell proliferation regulation of developmental process regulation of neuroblast proliferation cell development regulation of cell differentiation regulation of neurogenesis regulation of cell development negative regulation of neuroblast proliferation regulation of nervous system development negative regulation of neurogenesis negative regulation of nervous system development regulation of multicellular organismal process negative regulation of cell differentiation regulation of neural precursor cell proliferation negative regulation of cell population proliferation regulation of multicellular organismal development negative regulation of developmental process negative regulation of cell development regulation of cell population proliferation negative regulation of multicellular organismal process cellular component organization cellular component biogenesis cell junction organization cellular component assembly cell junction assembly cellular component organization or biogenesis apical junction assembly cell-cell junction assembly cell-cell junction organization cell migration cell motility female gonad development female sex differentiation development of primary female sexual characteristics ovarian follicle development gap junction assembly establishment or maintenance of cell polarity smoothened signaling pathway negative regulation of extrinsic apoptotic signaling pathway in absence of ligand negative regulation of signal transduction in absence of ligand negative regulation of extrinsic apoptotic signaling pathway negative regulation of apoptotic signaling pathway negative regulation of programmed cell death negative regulation of apoptotic process response to organic substance response to hormone response to chemical response to endogenous stimulus response to estrogen anatomical structure morphogenesis odontogenesis of dentin-containing tooth odontogenesis animal organ morphogenesis positive regulation of smoothened signaling pathway regulation of smoothened signaling pathway negative regulation of locomotion regulation of cell motility regulation of locomotion negative regulation of cell motility locomotion cell projection organization neuron projection development regeneration response to axon injury neuron projection regeneration axon regeneration neuron differentiation cellular response to stress response to stress response to wounding plasma membrane bounded cell projection organization axon development neuron development cellular response to nitrogen compound response to alcohol response to organonitrogen compound cellular response to organic cyclic compound response to oxygen-containing compound response to nitrogen compound cellular response to oxygen-containing compound cellular response to endogenous stimulus cellular response to chemical stimulus cellular response to alcohol cellular response to organonitrogen compound response to indole-3-methanol cellular response to indole-3-methanol cellular response to organic substance response to organic cyclic compound regulation of localization regulation of protein localization regulation of protein localization to nucleus protein localization to nucleus negative regulation of protein localization to nucleus regulation of cellular localization protein localization to organelle negative regulation of protein localization	cell projection cell leading edge cellular anatomical entity plasma membrane bounded cell projection lamellipodium cell-cell junction anchoring junction cell junction intracellular organelle intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle actin cytoskeleton cell projection cell leading edge cellular anatomical entity plasma membrane bounded cell projection lamellipodium cell-cell junction anchoring junction cell junction intracellular organelle intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle actin cytoskeleton non-membrane-bounded organelle cytoplasm cytosol cell periphery protein-containing complex extrinsic component of plasma membrane catenin complex plasma membrane protein complex membrane plasma membrane membrane protein complex extrinsic component of membrane membrane raft plasma membrane raft caveola membrane microdomain flotillin complex plasma membrane region adherens junction intercalated disc cell-cell contact zone acrosomal vesicle membrane-bounded organelle intracellular vesicle intracellular membrane-bounded organelle endomembrane system cytoplasmic vesicle secretory granule secretory vesicle vesicle focal adhesion cell-substrate junction apical junction complex zonula adherens

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR001033	Alpha-catenin	Family
A, B	IPR036723	Alpha-catenin/vinculin-like superfamily	Homologous Superfamily
A, B	IPR006077	Vinculin/alpha-catenin	Family
A, B	IPR000633	Vinculin, conserved site	Conserved Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P35221	acute myeloid leukemia myelodysplastic syndrome patterned macular dystrophy 2 patterned dystrophy of the retinal pigment epithelium gastrointestinal stromal tumor lymphoplasmacytic lymphoma malignant pancreatic neoplasm myopathy ovarian cancer pancreatic intraductal papillary-mucinous neoplasm astrocytic tumor dermatomyositis primitive neuroectodermal tumor gastric carcinoma Hematopoetic Myelodysplasia acute myeloid leukemia myelodysplastic syndrome patterned macular dystrophy 2 patterned dystrophy of the retinal pigment epithelium gastrointestinal stromal tumor lymphoplasmacytic lymphoma malignant pancreatic neoplasm myopathy ovarian cancer pancreatic intraductal papillary-mucinous neoplasm astrocytic tumor dermatomyositis primitive neuroectodermal tumor gastric carcinoma Hematopoetic Myelodysplasia invasive ductal breast carcinoma malignant ependymoma medulloblastoma oligodendroglioma pancreatic ductal adenocarcinoma atypical teratoid rhabdoid tumor pilocytic astrocytoma psoriasis exocrine pancreatic carcinoma hereditary diffuse gastric adenocarcinoma large cell medulloblastoma malignant glioma osteosarcoma pancreatic intraductal papillary-mucinous carcinoma patterned macular dystrophy autism spectrum disorder plasma cell myeloma gastric cancer glioblastoma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.