4I6P

Crystal structure of Par3-NTD domain

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Par3-NTD domain-like	8047159	4005475	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Ubiquitin-like	8105554	3000157	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Ubiquitin-like	8105554	3000157	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF12053	e4i6pA1	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: PF12053	ECOD (1.6)
B	PF12053	e4i6pB1	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: PF12053	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.10.20.90	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Phosphatidylinositol 3-kinase Catalytic Subunit	CATH (4.3.0)
B	3.10.20.90	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Phosphatidylinositol 3-kinase Catalytic Subunit	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF12053	N-terminal of Par3 and HAL proteins (Par3_HAL_N_term)	N-terminal of Par3 and HAL proteins	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Partitioning defective 3 homolog	binding phospholipid binding lipid binding phosphatidylinositol binding protein phosphatase binding phosphatase binding protein binding enzyme binding ion binding phosphatidylinositol-4,5-bisphosphate binding anion binding phosphatidylinositol bisphosphate binding phosphatidylinositol phosphate binding small molecule binding binding phospholipid binding lipid binding phosphatidylinositol binding protein phosphatase binding phosphatase binding protein binding enzyme binding ion binding phosphatidylinositol-4,5-bisphosphate binding anion binding phosphatidylinositol bisphosphate binding phosphatidylinositol phosphate binding small molecule binding phosphatidylinositol-3,4,5-trisphosphate binding phosphatidylinositol-3-phosphate binding identical protein binding	regulation of cellular process regulation of protein modification process regulation of protein phosphorylation negative regulation of biological process regulation of peptidyl-threonine phosphorylation negative regulation of phosphate metabolic process negative regulation of cellular metabolic process regulation of primary metabolic process organic substance metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process negative regulation of protein modification process negative regulation of cellular process peptidyl-amino acid modification regulation of cellular process regulation of protein modification process regulation of protein phosphorylation negative regulation of biological process regulation of peptidyl-threonine phosphorylation negative regulation of phosphate metabolic process negative regulation of cellular metabolic process regulation of primary metabolic process organic substance metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process negative regulation of protein modification process negative regulation of cellular process peptidyl-amino acid modification protein metabolic process peptidyl-threonine modification protein modification process phosphorus metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process regulation of biological process organonitrogen compound metabolic process protein phosphorylation phosphorylation regulation of protein metabolic process cellular metabolic process negative regulation of metabolic process biological regulation primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process negative regulation of protein phosphorylation macromolecule modification negative regulation of peptidyl-threonine phosphorylation negative regulation of phosphorus metabolic process metabolic process cellular process regulation of phosphorylation regulation of phosphorus metabolic process macromolecule metabolic process negative regulation of phosphorylation regulation of metabolic process peptidyl-threonine phosphorylation protein localization localization cellular localization cellular macromolecule localization macromolecule localization centrosome localization microtubule organizing center localization cell division developmental process multicellular organismal process cellular developmental process peripheral nervous system axon ensheathment peripheral nervous system development cell development nervous system development glial cell development myelination multicellular organism development neurogenesis Schwann cell development gliogenesis axon ensheathment ensheathment of neurons glial cell differentiation cell differentiation anatomical structure development myelination in peripheral nervous system Schwann cell differentiation system development regulation of localization import into cell regulation of cellular component organization positive regulation of cellular component organization receptor internalization transport positive regulation of biological process regulation of receptor internalization vesicle-mediated transport cellular component organization positive regulation of endocytosis cellular component organization or biogenesis positive regulation of receptor-mediated endocytosis positive regulation of cellular process regulation of endocytosis regulation of transport regulation of receptor-mediated endocytosis regulation of vesicle-mediated transport establishment of localization positive regulation of receptor internalization positive regulation of transport endocytosis receptor-mediated endocytosis regulation of cellular localization epithelium development actin filament-based movement tissue development cell morphogenesis epithelial cell differentiation anatomical structure morphogenesis epithelial cell development epithelial cell morphogenesis actin filament-based process actin-mediated cell contraction apical constriction establishment of cell polarity establishment of epithelial cell polarity establishment or maintenance of cell polarity establishment of protein localization establishment of protein localization to membrane protein targeting localization within membrane protein localization to membrane protein targeting to membrane bicellular tight junction assembly tight junction organization apical junction assembly cellular component biogenesis cell junction organization cellular component assembly cell junction assembly tight junction assembly cell-cell junction assembly cell-cell junction organization cell cycle system process regulation of developmental process regulation of myelination regulation of system process regulation of nervous system development positive regulation of myelination positive regulation of nervous system process regulation of multicellular organismal process regulation of multicellular organismal development nervous system process regulation of nervous system process positive regulation of multicellular organismal process cell adhesion organelle organization microtubule cytoskeleton organization microtubule-based process cytoskeleton organization regulation of actin filament-based process wound healing response to stimulus morphogenesis of an epithelium epiboly involved in wound healing morphogenesis of an epithelial sheet tissue morphogenesis response to stress epiboly cell migration wound healing, spreading of cells cell motility response to wounding establishment of organelle localization organelle localization establishment of localization in cell establishment of centrosome localization establishment or maintenance of bipolar cell polarity establishment or maintenance of epithelial cell apical/basal polarity establishment or maintenance of apical/basal cell polarity	cellular anatomical entity endomembrane system cell junction growth cone axon cell projection distal axon neuron projection axonal growth cone plasma membrane bounded cell projection site of polarized growth apical part of cell cell periphery cell cortex cellular anatomical entity endomembrane system cell junction growth cone axon cell projection distal axon neuron projection axonal growth cone plasma membrane bounded cell projection site of polarized growth apical part of cell cell periphery cell cortex intracellular anatomical structure cytoplasm cell-cell junction anchoring junction membrane plasma membrane plasma membrane region apical plasma membrane internode region of axon main axon protein-containing complex apical junction complex protein kinase complex transferase complex, transferring phosphorus-containing groups PAR polarity complex catalytic complex serine/threonine protein kinase complex transferase complex adherens junction compact myelin myelin sheath Schmidt-Lanterman incisure bicellular tight junction tight junction somatodendritic compartment cell body neuronal cell body intracellular organelle cytoskeleton spindle organelle intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle lateral loop

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR021922	Par3/HAL, N-terminal	Domain
A, B	IPR036034	PDZ superfamily	Homologous Superfamily
A, B	IPR001478	PDZ domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.