4HYC

Structure of a presenilin family intramembrane aspartate protease in P2 space group

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF06550	e4hycA2	A: alpha arrays	X: Presenilin family intramembrane aspartate proteases (From Topology)	H: Presenilin family intramembrane aspartate proteases (From Topology)	T: Presenilin family intramembrane aspartate proteases	F: PF06550	ECOD (1.6)
B	PF06550	e4hycB2	A: alpha arrays	X: Presenilin family intramembrane aspartate proteases (From Topology)	H: Presenilin family intramembrane aspartate proteases (From Topology)	T: Presenilin family intramembrane aspartate proteases	F: PF06550	ECOD (1.6)
C	PF06550	e4hycC2	A: alpha arrays	X: Presenilin family intramembrane aspartate proteases (From Topology)	H: Presenilin family intramembrane aspartate proteases (From Topology)	T: Presenilin family intramembrane aspartate proteases	F: PF06550	ECOD (1.6)
D	PF06550	e4hycD2	A: alpha arrays	X: Presenilin family intramembrane aspartate proteases (From Topology)	H: Presenilin family intramembrane aspartate proteases (From Topology)	T: Presenilin family intramembrane aspartate proteases	F: PF06550	ECOD (1.6)
E	PF06550	e4hycE2	A: alpha arrays	X: Presenilin family intramembrane aspartate proteases (From Topology)	H: Presenilin family intramembrane aspartate proteases (From Topology)	T: Presenilin family intramembrane aspartate proteases	F: PF06550	ECOD (1.6)
F	PF06550	e4hycF2	A: alpha arrays	X: Presenilin family intramembrane aspartate proteases (From Topology)	H: Presenilin family intramembrane aspartate proteases (From Topology)	T: Presenilin family intramembrane aspartate proteases	F: PF06550	ECOD (1.6)
G	PF06550	e4hycG2	A: alpha arrays	X: Presenilin family intramembrane aspartate proteases (From Topology)	H: Presenilin family intramembrane aspartate proteases (From Topology)	T: Presenilin family intramembrane aspartate proteases	F: PF06550	ECOD (1.6)
H	PF06550	e4hycH2	A: alpha arrays	X: Presenilin family intramembrane aspartate proteases (From Topology)	H: Presenilin family intramembrane aspartate proteases (From Topology)	T: Presenilin family intramembrane aspartate proteases	F: PF06550	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H	PF06550	Signal-peptide peptidase, presenilin aspartyl protease (SPP)	Signal-peptide peptidase, presenilin aspartyl protease	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H	Putative uncharacterized protein	aspartic-type peptidase activity peptidase activity catalytic activity, acting on a protein hydrolase activity aspartic endopeptidase activity, intramembrane cleaving aspartic-type endopeptidase activity catalytic activity endopeptidase activity identical protein binding protein binding binding	-	membrane cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H	IPR006639	Presenilin/signal peptide peptidase	Family
A, B, C, D, E A, B, C, D, E, F, G, H	IPR010545	Signal-peptide peptidase, presenilin aspartyl protease	Family

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B, C, D, E A, B, C, D, E, F, G, H	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B, C, D, E A, B, C, D, E, F, G, H	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B, C, D, E A, B, C, D, E, F, G, H	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Intramembrane Proteases	PSH presenilin/SPP homologue aspartate protease (C222 space group)

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.