4HRE

Crystal Structure of p11/Annexin A2 Heterotetramer in Complex with SMARCA3 Peptide

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Annexin	8071859	4001063	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Annexin	8071860	3000627	SCOP2 (2022-06-29)
G [auth B]	SCOP2B Superfamily	Annexin	8071860	3000627	SCOP2B (2022-06-29)
H [auth D]	SCOP2B Superfamily	Annexin	8071860	3000627	SCOP2B (2022-06-29)
B [auth C]	SCOP2B Superfamily	Annexin	8071860	3000627	SCOP2B (2022-06-29)
C [auth E]	SCOP2B Superfamily	EF-hand	8037283	3001983	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	EF-hand	8037283	3001983	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	EF-hand	8037283	3001983	SCOP2B (2022-06-29)
D [auth F]	SCOP2B Superfamily	EF-hand	8037283	3001983	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00191	e4hreA5	A: alpha arrays	X: Annexin (From Topology)	H: Annexin (From Topology)	T: Annexin	F: PF00191	ECOD (1.6)
G [auth B]	PF00191	e4hreB5	A: alpha arrays	X: Annexin (From Topology)	H: Annexin (From Topology)	T: Annexin	F: PF00191	ECOD (1.6)
H [auth D]	PF00191	e4hreD5	A: alpha arrays	X: Annexin (From Topology)	H: Annexin (From Topology)	T: Annexin	F: PF00191	ECOD (1.6)
B [auth C]	PF00191	e4hreC5	A: alpha arrays	X: Annexin (From Topology)	H: Annexin (From Topology)	T: Annexin	F: PF00191	ECOD (1.6)
C [auth E]	PF01023	e4hreE1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF01023	ECOD (1.6)
I	PF01023	e4hreI1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF01023	ECOD (1.6)
J	PF01023	e4hreJ1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF01023	ECOD (1.6)
D [auth F]	PF01023	e4hreF1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF01023	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.220.10	Mainly Alpha	Orthogonal Bundle	Annexin V	domain 1	CATH (4.3.0)
G [auth B]	1.10.220.10	Mainly Alpha	Orthogonal Bundle	Annexin V	domain 1	CATH (4.3.0)
H [auth D]	1.10.220.10	Mainly Alpha	Orthogonal Bundle	Annexin V	domain 1	CATH (4.3.0)
B [auth C]	1.10.220.10	Mainly Alpha	Orthogonal Bundle	Annexin V	domain 1	CATH (4.3.0)
C [auth E]	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
I	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
J	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
D [auth F]	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B [auth C], G [auth B], H [auth D]	PF00191	Annexin (Annexin)	Annexin	This family of annexins also includes giardin that has been shown to function as an annexin [1].	Domain
C [auth E], D [auth F], I, J	PF01023	S-100/ICaBP type calcium binding domain (S_100)	S-100/ICaBP type calcium binding domain	The S-100 domain is a subfamily of the EF-hand calcium binding proteins.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B [auth C], G [auth B], H [auth D]	Annexin A2	small GTPase binding protein binding binding enzyme binding GTPase binding extracellular matrix binding bone sialoprotein binding cytoskeletal protein binding calcium-dependent phospholipid binding phospholipid binding lipid binding calcium channel activity monoatomic cation transmembrane transporter activity monoatomic ion channel activity small GTPase binding protein binding binding enzyme binding GTPase binding extracellular matrix binding bone sialoprotein binding cytoskeletal protein binding calcium-dependent phospholipid binding phospholipid binding lipid binding calcium channel activity monoatomic cation transmembrane transporter activity monoatomic ion channel activity monoatomic cation channel activity passive transmembrane transporter activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity identical protein binding modified amino acid binding phosphatidylserine binding cation binding ion binding calcium ion binding metal ion binding small molecule binding protease binding phosphatidylinositol-4,5-bisphosphate binding anion binding phosphatidylinositol bisphosphate binding phosphatidylinositol phosphate binding phosphatidylinositol binding enzyme regulator activity molecular function inhibitor activity peptidase regulator activity serine-type endopeptidase inhibitor activity molecular function regulator activity enzyme inhibitor activity peptidase inhibitor activity endopeptidase regulator activity endopeptidase inhibitor activity S100 protein binding calcium-dependent protein binding virion binding phospholipase inhibitor activity phospholipase A2 inhibitor activity lipase inhibitor activity	developmental process multicellular organismal process regulation of multicellular organismal development regulation of biological process regulation of cellular process regulation of developmental process cellular developmental process biological regulation cell development regulation of neurogenesis regulation of cell differentiation nervous system development regulation of cell development regulation of nervous system development multicellular organism development developmental process multicellular organismal process regulation of multicellular organismal development regulation of biological process regulation of cellular process regulation of developmental process cellular developmental process biological regulation cell development regulation of neurogenesis regulation of cell differentiation nervous system development regulation of cell development regulation of nervous system development multicellular organism development neurogenesis cell differentiation anatomical structure development regulation of multicellular organismal process cellular process system development regulation of protein maturation positive regulation of protein maturation positive regulation of macromolecule biosynthetic process positive regulation of protein processing protein maturation regulation of primary metabolic process positive regulation of metabolic process positive regulation of plasminogen activation regulation of proteolysis proteolysis organic substance biosynthetic process positive regulation of macromolecule metabolic process plasminogen activation zymogen activation cellular metabolic process regulation of protein metabolic process primary metabolic process regulation of cellular metabolic process regulation of gene expression biosynthetic process positive regulation of proteolysis regulation of protein processing protein processing metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of metabolic process cellular biosynthetic process positive regulation of protein metabolic process positive regulation of biological process positive regulation of cellular metabolic process organic substance metabolic process positive regulation of biosynthetic process regulation of plasminogen activation protein metabolic process positive regulation of cellular process regulation of biosynthetic process organonitrogen compound metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process positive regulation of gene expression positive regulation of cellular biosynthetic process regulation of body fluid levels response to stimulus regulation of response to external stimulus negative regulation of biological process regulation of response to wounding regulation of coagulation response to stress regulation of response to stress coagulation regulation of biological quality response to wounding regulation of hemostasis wound healing negative regulation of response to stimulus negative regulation of wound healing regulation of blood coagulation negative regulation of blood coagulation hemostasis response to external stimulus negative regulation of response to wounding blood coagulation negative regulation of hemostasis fibrinolysis negative regulation of coagulation regulation of response to stimulus negative regulation of response to external stimulus regulation of wound healing negative regulation of multicellular organismal process protein localization localization protein localization to cell periphery cellular localization protein localization to plasma membrane cellular macromolecule localization macromolecule localization localization within membrane protein localization to membrane regulation of localization import into cell regulation of cellular component organization receptor internalization transport negative regulation of transport negative regulation of endocytosis regulation of receptor internalization vesicle-mediated transport cellular component organization negative regulation of cellular process cellular component organization or biogenesis regulation of endocytosis negative regulation of cellular component organization regulation of transport negative regulation of receptor-mediated endocytosis regulation of receptor-mediated endocytosis regulation of vesicle-mediated transport establishment of localization endocytosis receptor-mediated endocytosis negative regulation of receptor internalization positive regulation of organelle organization positive regulation of cellular component organization membrane fusion organelle membrane fusion regulation of vesicle fusion vesicle organization membrane organization regulation of organelle organization organelle fusion organelle organization positive regulation of transport positive regulation of vesicle fusion vesicle fusion collagen fibril organization extracellular matrix organization supramolecular fiber organization extracellular structure organization external encapsulating structure organization body fluid secretion secretion positive regulation of low-density lipoprotein particle clearance regulation of plasma lipoprotein particle levels regulation of low-density lipoprotein particle clearance positive regulation of lipoprotein particle clearance plasma lipoprotein particle clearance regulation of lipoprotein particle clearance positive regulation of multicellular organismal process low-density lipoprotein particle clearance regulation of receptor-mediated endocytosis involved in cholesterol transport positive regulation of intracellular lipid transport positive regulation of intracellular cholesterol transport regulation of intracellular cholesterol transport positive regulation of endocytosis establishment of localization in cell sterol transport positive regulation of receptor-mediated endocytosis regulation of intracellular transport regulation of sterol transport intracellular lipid transport organic substance transport intracellular transport lipid transport positive regulation of lipid transport cholesterol transport positive regulation of sterol transport regulation of intracellular sterol transport intracellular cholesterol transport regulation of lipid transport positive regulation of receptor-mediated endocytosis involved in cholesterol transport organic hydroxy compound transport intracellular sterol transport receptor-mediated endocytosis involved in cholesterol transport positive regulation of intracellular transport positive regulation of intracellular sterol transport regulation of cholesterol transport positive regulation of cholesterol transport regulation of intracellular lipid transport lipid localization positive regulation of lipid localization regulation of cellular localization regulation of lipid localization vesicle budding from membrane cellular component biogenesis cellular component assembly membrane raft organization membrane biogenesis membrane raft assembly membrane assembly mRNA transcription by RNA polymerase II RNA metabolic process mRNA transcription nucleobase-containing compound metabolic process RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II nucleobase-containing compound biosynthetic process mRNA metabolic process nucleic acid metabolic process organic cyclic compound metabolic process organic cyclic compound biosynthetic process cell adhesion myeloid leukocyte differentiation hemopoiesis animal organ development osteoclast development skeletal system development myeloid cell differentiation osteoclast differentiation bone cell development myeloid cell development bone development leukocyte differentiation positive regulation of protein binding regulation of binding positive regulation of binding regulation of low-density lipoprotein particle receptor binding regulation of protein binding regulation of molecular function positive regulation of molecular function regulation of receptor binding positive regulation of receptor binding positive regulation of low-density lipoprotein particle receptor binding positive regulation of low-density lipoprotein receptor activity regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process regulation of DNA-templated transcription positive regulation of DNA-templated transcription regulation of RNA biosynthetic process positive regulation of RNA biosynthetic process vacuole organization positive regulation of vacuole organization regulation of vacuole organization cell-matrix adhesion cell-substrate adhesion negative regulation of cellular catabolic process receptor catabolic process catabolic process macromolecule catabolic process negative regulation of cellular metabolic process negative regulation of protein catabolic process cellular catabolic process negative regulation of low-density lipoprotein particle receptor catabolic process receptor metabolic process regulation of low-density lipoprotein particle receptor catabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process organonitrogen compound catabolic process negative regulation of catabolic process negative regulation of receptor catabolic process negative regulation of metabolic process low-density lipoprotein particle receptor catabolic process protein catabolic process regulation of catabolic process low-density lipoprotein receptor particle metabolic process regulation of receptor catabolic process regulation of cellular catabolic process organic substance catabolic process regulation of protein catabolic process blood vessel morphogenesis tube development angiogenesis vasculature development circulatory system development anatomical structure morphogenesis tube morphogenesis anatomical structure formation involved in morphogenesis blood vessel development positive regulation of secretion by cell positive regulation of exocytosis regulation of secretion by cell secretion by cell positive regulation of secretion export from cell regulation of secretion exocytosis regulation of exocytosis fibroblast proliferation cell population proliferation positive regulation of cell population proliferation regulation of fibroblast proliferation regulation of cell population proliferation positive regulation of fibroblast proliferation response to activity apoptotic process cell death programmed cell death epithelial cell apoptotic process respiratory tube development lung development respiratory system development regulation of signaling signaling regulation of receptor recycling receptor recycling positive regulation of receptor recycling positive regulation of signaling plasma membrane repair regulation of plasma membrane organization plasma membrane organization regulation of plasma membrane repair positive regulation of plasma membrane repair endomembrane system organization positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of phosphate metabolic process positive regulation of protein modification process regulation of phosphate metabolic process phosphate-containing compound metabolic process positive regulation of protein phosphorylation phosphorus metabolic process protein modification process protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation macromolecule modification regulation of phosphorus metabolic process regulation of phosphorylation	cell periphery plasma membrane membrane cellular anatomical entity cornified envelope basement membrane extracellular matrix external encapsulating structure collagen-containing extracellular matrix extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region cell periphery plasma membrane membrane cellular anatomical entity cornified envelope basement membrane extracellular matrix external encapsulating structure collagen-containing extracellular matrix extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol myelin sheath adaxonal region myelin sheath sarcolemma basal part of cell basal plasma membrane plasma membrane region basolateral plasma membrane endosome intracellular vesicle intracellular membrane-bounded organelle macropinosome endomembrane system intracellular organelle cytoplasmic vesicle pinosome endosome membrane late endosome membrane cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane late endosome organelle membrane PCSK9-AnxA2 complex protein-containing complex vacuolar membrane lytic vacuole vacuole lytic vacuole membrane lysosomal membrane lysosome plasma membrane protein complex membrane protein complex ruffle cell projection cell leading edge plasma membrane bounded cell projection perinuclear region of cytoplasm midbody nucleus membrane-enclosed lumen intracellular organelle lumen organelle lumen nuclear periphery nuclear lumen nuclear matrix pigment granule melanosome AnxA2-p11 complex cell cortex RNA polymerase II transcription regulator complex nuclear protein-containing complex transcription regulator complex cell surface membrane microdomain membrane raft early endosome compact myelin Schmidt-Lanterman incisure lipid droplet intracellular non-membrane-bounded organelle non-membrane-bounded organelle
C [auth E], D [auth F], I, J	Protein S100-A10	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding protein binding transmembrane transporter binding identical protein binding protein homodimerization activity protein dimerization activity calcium-dependent protein binding	developmental process multicellular organismal process regulation of multicellular organismal development regulation of biological process regulation of cellular process regulation of developmental process cellular developmental process biological regulation cell development regulation of neurogenesis regulation of cell differentiation nervous system development regulation of cell development regulation of nervous system development multicellular organism development developmental process multicellular organismal process regulation of multicellular organismal development regulation of biological process regulation of cellular process regulation of developmental process cellular developmental process biological regulation cell development regulation of neurogenesis regulation of cell differentiation nervous system development regulation of cell development regulation of nervous system development multicellular organism development neurogenesis cell differentiation anatomical structure development regulation of multicellular organismal process cellular process system development regulation of protein maturation positive regulation of protein maturation positive regulation of macromolecule biosynthetic process positive regulation of protein processing protein maturation regulation of primary metabolic process positive regulation of metabolic process positive regulation of plasminogen activation regulation of proteolysis proteolysis organic substance biosynthetic process positive regulation of macromolecule metabolic process plasminogen activation zymogen activation cellular metabolic process regulation of protein metabolic process primary metabolic process regulation of cellular metabolic process regulation of gene expression biosynthetic process positive regulation of proteolysis regulation of protein processing protein processing metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of metabolic process cellular biosynthetic process positive regulation of protein metabolic process positive regulation of biological process positive regulation of cellular metabolic process organic substance metabolic process positive regulation of biosynthetic process regulation of plasminogen activation protein metabolic process positive regulation of cellular process regulation of biosynthetic process organonitrogen compound metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process positive regulation of gene expression positive regulation of cellular biosynthetic process regulation of localization transport positive regulation of secretion by cell positive regulation of exocytosis vesicle-mediated transport localization regulation of secretion by cell secretion by cell positive regulation of secretion regulation of transport secretion export from cell regulation of vesicle-mediated transport establishment of localization regulation of secretion positive regulation of transport exocytosis regulation of exocytosis positive regulation of molecular function regulation of molecular function positive regulation of hydrolase activity regulation of catalytic activity regulation of hydrolase activity positive regulation of catalytic activity regulation of GTPase activity positive regulation of GTPase activity protein localization protein localization to cell periphery cellular localization protein localization to plasma membrane cellular macromolecule localization macromolecule localization localization within membrane protein localization to membrane positive regulation of substrate adhesion-dependent cell spreading regulation of cell-substrate adhesion positive regulation of cell adhesion regulation of substrate adhesion-dependent cell spreading regulation of cell adhesion cell-substrate adhesion cell adhesion positive regulation of cell-substrate adhesion substrate adhesion-dependent cell spreading regulation of cellular component organization positive regulation of cellular component organization cell-substrate junction assembly positive regulation of cell-substrate junction organization cellular component organization cellular component biogenesis cellular component assembly cell junction assembly regulation of cell-substrate junction organization cellular component organization or biogenesis focal adhesion assembly positive regulation of focal adhesion assembly positive regulation of cellular component biogenesis positive regulation of cell-matrix adhesion regulation of cellular component biogenesis regulation of cell junction assembly positive regulation of cell junction assembly cell junction organization cell-matrix adhesion regulation of cell-matrix adhesion cell-substrate junction organization regulation of focal adhesion assembly regulation of cell-substrate junction assembly membrane organization vesicle budding from membrane vesicle organization organelle organization wound healing response to stimulus plasma membrane repair regulation of plasma membrane organization response to stress plasma membrane organization regulation of plasma membrane repair positive regulation of plasma membrane repair response to wounding endomembrane system organization membrane raft organization membrane biogenesis membrane raft assembly membrane assembly mRNA transcription by RNA polymerase II RNA metabolic process mRNA transcription nucleobase-containing compound metabolic process RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II nucleobase-containing compound biosynthetic process mRNA metabolic process nucleic acid metabolic process organic cyclic compound metabolic process organic cyclic compound biosynthetic process regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process regulation of DNA-templated transcription positive regulation of DNA-templated transcription regulation of RNA biosynthetic process positive regulation of RNA biosynthetic process positive regulation of organelle organization regulation of cytoskeleton organization regulation of actin filament-based process regulation of actin filament bundle assembly positive regulation of actin filament bundle assembly actin filament bundle organization positive regulation of stress fiber assembly actin filament-based process stress fiber assembly regulation of actin filament organization actin cytoskeleton organization actomyosin structure organization positive regulation of cytoskeleton organization actin filament organization positive regulation of supramolecular fiber organization regulation of organelle organization regulation of stress fiber assembly contractile actin filament bundle assembly regulation of actomyosin structure organization actin filament bundle assembly regulation of actin cytoskeleton organization regulation of supramolecular fiber organization supramolecular fiber organization cytoskeleton organization	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle organelle lumen organelle nuclear periphery nuclear lumen nuclear matrix protein-containing complex membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle organelle lumen organelle nuclear periphery nuclear lumen nuclear matrix protein-containing complex AnxA2-p11 complex RNA polymerase II transcription regulator complex nuclear protein-containing complex transcription regulator complex extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix cell surface plasma membrane membrane cytoplasm plasma membrane protein complex membrane protein complex
E [auth G], F [auth H], K, L	Helicase-like transcription factor	catalytic activity, acting on a nucleic acid helicase activity catalytic activity ATP-dependent activity ATP-dependent activity, acting on DNA catalytic activity, acting on DNA RNA binding binding organic cyclic compound binding nucleic acid binding aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity catalytic activity, acting on a nucleic acid helicase activity catalytic activity ATP-dependent activity ATP-dependent activity, acting on DNA catalytic activity, acting on DNA RNA binding binding organic cyclic compound binding nucleic acid binding aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity transferase activity ubiquitin-protein transferase activity ATP-dependent chromatin remodeler activity adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding DNA binding hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides ubiquitin protein ligase binding protein binding ubiquitin-like protein ligase binding enzyme binding cation binding transition metal ion binding zinc ion binding metal ion binding	developmental process multicellular organismal process regulation of multicellular organismal development regulation of biological process regulation of cellular process regulation of developmental process cellular developmental process biological regulation cell development regulation of neurogenesis regulation of cell differentiation nervous system development regulation of cell development regulation of nervous system development multicellular organism development developmental process multicellular organismal process regulation of multicellular organismal development regulation of biological process regulation of cellular process regulation of developmental process cellular developmental process biological regulation cell development regulation of neurogenesis regulation of cell differentiation nervous system development regulation of cell development regulation of nervous system development multicellular organism development neurogenesis cell differentiation anatomical structure development regulation of multicellular organismal process cellular process system development organonitrogen compound metabolic process primary metabolic process organic substance metabolic process protein ubiquitination macromolecule modification metabolic process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal cellular response to stimulus response to stimulus DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process cellular response to stress DNA damage response response to stress DNA repair mRNA transcription by RNA polymerase II cellular biosynthetic process RNA metabolic process mRNA transcription RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II organic substance biosynthetic process cellular metabolic process nucleobase-containing compound biosynthetic process gene expression mRNA metabolic process macromolecule biosynthetic process biosynthetic process organic cyclic compound biosynthetic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process positive regulation of metabolic process regulation of RNA metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process regulation of cellular metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process regulation of gene expression regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process positive regulation of DNA-templated transcription positive regulation of biological process positive regulation of cellular metabolic process positive regulation of biosynthetic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of macromolecule metabolic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle organelle lumen organelle nuclear periphery nuclear lumen nuclear matrix nucleolus membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle organelle lumen organelle nuclear periphery nuclear lumen nuclear matrix nucleolus intracellular non-membrane-bounded organelle non-membrane-bounded organelle membrane RNA polymerase II transcription regulator complex protein-containing complex nuclear protein-containing complex transcription regulator complex cell periphery plasma membrane cytoplasm nucleoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B [auth C], G [auth B], H [auth D]	IPR002389	Annexin A2	Family
A, B [auth C], G [auth B], H [auth D]	IPR018252	Annexin repeat, conserved site	Conserved Site
A, B [auth C], G [auth B], H [auth D]	IPR037104	Annexin superfamily	Homologous Superfamily
A, B [auth C], G [auth B], H [auth D]	IPR018502	Annexin repeat	Repeat
A, B [auth C], G [auth B], H [auth D]	IPR001464	Annexin	Family
C [auth E], D [auth F], I, J	IPR028476	Protein S100-A10	Family
C [auth E], D [auth F], I, J	IPR001751	S100/Calcium binding protein 7/8-like, conserved site	Conserved Site
C [auth E], D [auth F], I, J	IPR011992	EF-hand domain pair	Homologous Superfamily
C [auth E], D [auth F], I, J	IPR013787	S100/CaBP-9k-type, calcium binding, subdomain	Domain
E [auth G], F [auth H], K, L	IPR000330	SNF2, N-terminal	Domain
E [auth G], F [auth H], K, L	IPR049730	SNF2/RAD5-like, C-terminal helicase domain	Domain
E [auth G], F [auth H], K, L	IPR014905	HIRAN domain	Domain
E [auth G], F [auth H], K, L	IPR038718	SNF2-like, N-terminal domain superfamily	Homologous Superfamily
E [auth G], F [auth H], K, L	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
E [auth G], F [auth H], K, L	IPR017907	Zinc finger, RING-type, conserved site	Conserved Site
E [auth G], F [auth H], K, L	IPR001650	Helicase, C-terminal domain-like	Domain
E [auth G], F [auth H], K, L	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
E [auth G], F [auth H], K, L	IPR014001	Helicase superfamily 1/2, ATP-binding domain	Domain
E [auth G], F [auth H], K, L	IPR001841	Zinc finger, RING-type	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
C [auth E], D [auth F], I, J	Pharos: P60903	acute myeloid leukemia medulloblastoma keloid Liver Cirrhosis, Experimental melanotic medulloblastoma adult medulloblastoma medullomyoblastoma with myogenic differentiation endogenous depression melancholia childhood medulloblastoma Duchenne muscular dystrophy gastric carcinoma adenoma malignant glioma atypical teratoid rhabdoid tumor acute myeloid leukemia medulloblastoma keloid Liver Cirrhosis, Experimental melanotic medulloblastoma adult medulloblastoma medullomyoblastoma with myogenic differentiation endogenous depression melancholia childhood medulloblastoma Duchenne muscular dystrophy gastric carcinoma adenoma malignant glioma atypical teratoid rhabdoid tumor breast cancer neurotic disorder cystic fibrosis pancreatic intraductal papillary-mucinous neoplasm depressive disorder pituitary cancer desmoplastic/nodular medulloblastoma Emery-Dreifuss muscular dystrophy glioblastoma large cell medulloblastoma lung cancer major depressive disorder malignant pancreatic neoplasm Becker muscular dystrophy breast fibroadenoma ovarian cancer Pick disease subependymal giant cell astrocytoma juvenile dermatomyositis limb-girdle muscular dystrophy lung carcinoma malignant ependymoma astrocytic tumor MALT lymphoma bipolar disorder pancreatic ductal adenocarcinoma pilocytic astrocytoma
E [auth G], F [auth H], K, L	Pharos: Q14527	breast cancer kidney neoplasm lung carcinoma non-small cell lung carcinoma psoriasis IgA glomerulonephritis lung adenocarcinoma Malignant neoplasm of kidney ovarian cancer kidney cancer lung cancer medulloblastoma progressive supranuclear palsy

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.