Annotations: 4HPP

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Glutamine synthetase N-terminal domain	8046383	4001002	SCOP2 (2022-06-29)
A	SCOP2 Family	Glutamine synthetase catalytic domain	8095915	4002006	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	GS N-terminal domain-like	8095916	3000408	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Glutamine synthetase/guanido kinase	8095917	3000676	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF16952	e4hppA2	A: beta barrels	X: Ribosomal protein L25-like	H: Glutamine synthetase, N-terminal domain (From Topology)	T: Glutamine synthetase, N-terminal domain	F: PF16952	ECOD (1.6)
A	PF00120	e4hppA1	A: a+b two layers	X: Glutamine synthetase-like	H: Glutamine synthetase/guanido kinase (From Topology)	T: Glutamine synthetase/guanido kinase	F: PF00120	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.10.20.70	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Glutamine synthetase, N-terminal domain	CATH (4.3.0)
A	3.30.590.10	Alpha Beta	2-Layer Sandwich	Creatine Kinase	Chain A, domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00120	Glutamine synthetase, catalytic domain (Gln-synt_C)	Glutamine synthetase, catalytic domain	-	Domain
A	PF16952	Glutamine synthetase N-terminal domain (Gln-synt_N_2)	Glutamine synthetase N-terminal domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Probable glutamine synthetase	acid-ammonia (or amide) ligase activity ammonia ligase activity glutamine synthetase activity catalytic activity ligase activity, forming carbon-nitrogen bonds ligase activity cation binding ion binding binding metal ion binding small molecule binding	glutamine family amino acid biosynthetic process oxoacid metabolic process cellular biosynthetic process organonitrogen compound biosynthetic process amino acid metabolic process organic acid metabolic process organic acid biosynthetic process alpha-amino acid metabolic process carboxylic acid biosynthetic process glutamine family amino acid metabolic process organic substance metabolic process organic substance biosynthetic process small molecule metabolic process glutamine metabolic process glutamine family amino acid biosynthetic process oxoacid metabolic process cellular biosynthetic process organonitrogen compound biosynthetic process amino acid metabolic process organic acid metabolic process organic acid biosynthetic process alpha-amino acid metabolic process carboxylic acid biosynthetic process glutamine family amino acid metabolic process organic substance metabolic process organic substance biosynthetic process small molecule metabolic process glutamine metabolic process organonitrogen compound metabolic process small molecule biosynthetic process cellular metabolic process carboxylic acid metabolic process primary metabolic process L-amino acid biosynthetic process L-amino acid metabolic process proteinogenic amino acid metabolic process amino acid biosynthetic process biosynthetic process proteinogenic amino acid biosynthetic process metabolic process cellular process glutamine biosynthetic process alpha-amino acid biosynthetic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR008146	Glutamine synthetase, catalytic domain	Domain
A	IPR014746	Glutamine synthetase/guanido kinase, catalytic domain	Homologous Superfamily
A	IPR008147	Glutamine synthetase, N-terminal domain	Domain
A	IPR036651	Glutamine synthetase, N-terminal domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.