Annotations: 4HPF

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF03493	e4hpfA3	A: a+b two layers	X: TrkA C-terminal domain-like (From Topology)	H: TrkA C-terminal domain-like (From Topology)	T: TrkA C-terminal domain-like	F: PF03493	ECOD (1.6)
A	PF21014	e4hpfA4	A: a+b two layers	X: TrkA C-terminal domain-like (From Topology)	H: TrkA C-terminal domain-like (From Topology)	T: TrkA C-terminal domain-like	F: PF21014	ECOD (1.6)
A	PF22614	e4hpfA1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF22614	ECOD (1.6)
B	PF03493	e4hpfB3	A: a+b two layers	X: TrkA C-terminal domain-like (From Topology)	H: TrkA C-terminal domain-like (From Topology)	T: TrkA C-terminal domain-like	F: PF03493	ECOD (1.6)
B	PF21014	e4hpfB4	A: a+b two layers	X: TrkA C-terminal domain-like (From Topology)	H: TrkA C-terminal domain-like (From Topology)	T: TrkA C-terminal domain-like	F: PF21014	ECOD (1.6)
B	PF22614	e4hpfB1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF22614	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF21014	Ca2+-activated K+ channel Slowpoke, TrkA_C like domain (Slowpoke_C)	Ca2+-activated K+ channel Slowpoke, TrkA_C like domain	This domain is found at the cytoplasmic C-terminus of the drosophila slowpoke K+ channel. It is related to the TrkA C-terminal domain Pfam:PF02080.	Domain
A, B	PF03493	Calcium-activated BK potassium channel alpha subunit (BK_channel_a)	Calcium-activated BK potassium channel alpha subunit	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Potassium channel subfamily U member 1	monoatomic cation transmembrane transporter activity potassium ion transmembrane transporter activity monoatomic ion channel activity potassium channel activity monoatomic cation channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity channel activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity	reproductive process transport monoatomic ion transmembrane transport potassium ion transmembrane transport inorganic ion transmembrane transport establishment of localization metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport potassium ion transport cellular process reproductive process transport monoatomic ion transmembrane transport potassium ion transmembrane transport inorganic ion transmembrane transport establishment of localization metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport potassium ion transport cellular process monoatomic cation transport	cell periphery plasma membrane membrane cellular anatomical entity protein-containing complex transmembrane transporter complex membrane protein complex transporter complex monoatomic ion channel complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR005821	Ion transport domain	Domain
A, B	IPR047871	Calcium-activated potassium channel slowpoke-like	Family
A, B	IPR003929	Calcium-activated potassium channel BK, alpha subunit	Domain
A, B	IPR048735	Ca2+-activated K+ channel Slowpoke-like, C-terminal domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: A8MYU2	breast carcinoma large cell medulloblastoma Diabetes Mellitus, Non-Insulin-Dependent type 2 diabetes mellitus estrogen-receptor negative breast cancer

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Channels: Potassium, Sodium, & Proton Ion-Selective	SLO3 K⁺ Channel pH-sensitive Gating Ring

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.