4HL7

Crystal structure of nicotinate phosphoribosyltransferase (target NYSGR-026035) from Vibrio cholerae

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4hl7a2	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Nicotinate/Quinolinate PRTase C-terminal domain-like	automated matches	automated matches	(Vibrio cholerae O1 biovar El Tor str. N16961 ) [TaxId: 243277 ],	SCOPe (2.08)
A	d4hl7a1	Alpha and beta proteins (a+b)	alpha/beta-Hammerhead	Nicotinate/Quinolinate PRTase N-terminal domain-like	automated matches	automated matches	(Vibrio cholerae O1 biovar El Tor str. N16961 ) [TaxId: 243277 ],	SCOPe (2.08)
A	d4hl7a3	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Vibrio cholerae O1 biovar El Tor str. N16961 ) [TaxId: 243277 ],	SCOPe (2.08)
B	d4hl7b2	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Nicotinate/Quinolinate PRTase C-terminal domain-like	automated matches	automated matches	(Vibrio cholerae O1 biovar El Tor str. N16961 ) [TaxId: 243277 ],	SCOPe (2.08)
B	d4hl7b1	Alpha and beta proteins (a+b)	alpha/beta-Hammerhead	Nicotinate/Quinolinate PRTase N-terminal domain-like	automated matches	automated matches	(Vibrio cholerae O1 biovar El Tor str. N16961 ) [TaxId: 243277 ],	SCOPe (2.08)
B	d4hl7b3	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Vibrio cholerae O1 biovar El Tor str. N16961 ) [TaxId: 243277 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF17767	e4hl7A3	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: Nicotinate/Quinolinate PRTase N-terminal domain-like	F: PF17767	ECOD (1.6)
A	PF04095	e4hl7A2	A: a/b barrels	X: TIM beta/alpha-barrel	H: Nicotinate/Quinolinate PRTase C-terminal domain-like (From Topology)	T: Nicotinate/Quinolinate PRTase C-terminal domain-like	F: PF04095	ECOD (1.6)
B	PF17767	e4hl7B2	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: Nicotinate/Quinolinate PRTase N-terminal domain-like	F: PF17767	ECOD (1.6)
B	PF04095	e4hl7B1	A: a/b barrels	X: TIM beta/alpha-barrel	H: Nicotinate/Quinolinate PRTase C-terminal domain-like (From Topology)	T: Nicotinate/Quinolinate PRTase C-terminal domain-like	F: PF04095	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.20.140.10	Alpha Beta	Alpha-Beta Barrel	nicotinate phosphoribosyltransferase	nicotinate phosphoribosyltransferase	CATH (4.3.0)
B	3.20.140.10	Alpha Beta	Alpha-Beta Barrel	nicotinate phosphoribosyltransferase	nicotinate phosphoribosyltransferase	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF04095	Nicotinate phosphoribosyltransferase (NAPRTase) family (NAPRTase)	Nicotinate phosphoribosyltransferase (NAPRTase) family	-	Family
A, B	PF17767	Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain (NAPRTase_N)	Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain	Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyses the first reaction in the NAD salvage synthesis. This is the N-terminal domain of the enzyme.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Nicotinate phosphoribosyltransferase	nicotinate phosphoribosyltransferase activity catalytic activity ligase activity, forming carbon-nitrogen bonds ligase activity	pyridine nucleotide salvage nucleotide biosynthetic process organonitrogen compound biosynthetic process NAD metabolic process nucleotide salvage nucleobase-containing compound metabolic process organic substance metabolic process purine nucleotide metabolic process nucleobase-containing small molecule metabolic process purine-containing compound biosynthetic process purine nucleotide salvage organic substance biosynthetic process phosphate-containing compound metabolic process pyridine-containing compound metabolic process pyridine nucleotide salvage nucleotide biosynthetic process organonitrogen compound biosynthetic process NAD metabolic process nucleotide salvage nucleobase-containing compound metabolic process organic substance metabolic process purine nucleotide metabolic process nucleobase-containing small molecule metabolic process purine-containing compound biosynthetic process purine nucleotide salvage organic substance biosynthetic process phosphate-containing compound metabolic process pyridine-containing compound metabolic process small molecule metabolic process cellular metabolic compound salvage phosphorus metabolic process pyridine nucleotide metabolic process NAD biosynthetic process pyridine nucleotide biosynthetic process nucleoside phosphate metabolic process nicotinamide nucleotide metabolic process NAD salvage organonitrogen compound metabolic process purine-containing compound salvage cellular metabolic process pyridine-containing compound biosynthetic process primary metabolic process nucleobase-containing compound biosynthetic process nucleotide metabolic process purine-containing compound metabolic process nicotinamide nucleotide biosynthetic process organic cyclic compound metabolic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process organic cyclic compound biosynthetic process nucleoside phosphate biosynthetic process metabolic process cellular process purine nucleotide biosynthetic process	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR040727	Nicotinate phosphoribosyltransferase, N-terminal domain	Domain
A, B	IPR007229	Nicotinate phosphoribosyltransferase family	Family
A, B	IPR041525	Nicotinate/nicotinamide phosphoribosyltransferase	Domain
A, B	IPR006406	Nicotinate phosphoribosyltransferase	Family
A, B	IPR036068	Nicotinate phosphoribosyltransferase-like, C-terminal	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.