4HGM

Shark IgNAR Variable Domain

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
IMGT Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4hgma_	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	automated matches	Dogfish Shark (Squalus acanthias ) [TaxId: 7797 ],	SCOPe (2.08)
B	d4hgmb1	All alpha proteins	Serum albumin-like	Serum albumin-like	Serum albumin-like	Serum albumin	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Serum albumin-like	8033044	3001552	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Serum albumin-like	8033045	3001552	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Beta-APP	e4hgmA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Beta-APP	ECOD (1.6)
B	Serum_albumin	e4hgmB4	A: alpha complex topology	X: Serum albumin-like (From Topology)	H: Serum albumin-like (From Topology)	T: Serum albumin-like	F: Serum_albumin	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
B	1.10.246.10	Mainly Alpha	Orthogonal Bundle	Serum Albumin	Chain A, Domain 1	CATH (4.3.0)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
A	shark V-NAR antibody, E06, anti-albumin	VH	Squalus acanthias (spiny dogfish)	IGHV2S6*01	V-DOMAIN VH	IG	(VH)	IMGT (202415-0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B	PF00273	Serum albumin family (Serum_albumin)	Serum albumin family	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Shark V-NAR	-	-	-
B	Serum albumin	antioxidant activity vitamin binding vitamin B6 binding pyridoxal phosphate binding ion binding binding organic cyclic compound binding anion binding heterocyclic compound binding small molecule binding fatty acid binding organic acid binding lipid binding carboxylic acid binding antioxidant activity vitamin binding vitamin B6 binding pyridoxal phosphate binding ion binding binding organic cyclic compound binding anion binding heterocyclic compound binding small molecule binding fatty acid binding organic acid binding lipid binding carboxylic acid binding monocarboxylic acid binding protein binding exogenous protein binding cation binding transition metal ion binding copper ion binding metal ion binding toxic substance binding macrolide binding enterobactin binding protein-folding chaperone binding DNA binding nucleic acid binding identical protein binding	regulation of biological process regulation of cellular process regulation of mitochondrial depolarization negative regulation of membrane depolarization biological regulation negative regulation of biological process mitochondrial depolarization regulation of membrane depolarization regulation of mitochondrial membrane potential membrane depolarization cellular process regulation of biological quality negative regulation of mitochondrial depolarization regulation of membrane potential regulation of biological process regulation of cellular process regulation of mitochondrial depolarization negative regulation of membrane depolarization biological regulation negative regulation of biological process mitochondrial depolarization regulation of membrane depolarization regulation of mitochondrial membrane potential membrane depolarization cellular process regulation of biological quality negative regulation of mitochondrial depolarization regulation of membrane potential cellular response to stimulus cellular response to nutrient levels response to nutrient levels response to stimulus cellular response to stress response to stress response to starvation cellular response to calcium ion starvation cellular response to starvation	extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm protein-containing complex blood microparticle extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm protein-containing complex blood microparticle intracellular organelle Golgi apparatus intracellular membrane-bounded organelle endomembrane system membrane-enclosed lumen intracellular organelle lumen endoplasmic reticulum lumen organelle lumen endoplasmic reticulum vesicle lumen intracellular vesicle cytoplasmic vesicle lumen secretory granule lumen cytoplasmic vesicle secretory granule secretory vesicle platelet alpha granule platelet alpha granule lumen nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B	IPR020857	Serum albumin, conserved site	Conserved Site
B	IPR000264	ALB/AFP/VDB	Family
B	IPR014760	Serum albumin, N-terminal	Domain
B	IPR020858	Serum albumin-like	Homologous Superfamily
B	IPR021177	Serum albumin/Alpha-fetoprotein/Afamin	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B	Pharos: P02768	thrombocytopenia pancreatitis Stevens-Johnson syndrome allergic disease angioedema hyperthyroxinemia, familial dysalbuminemic myopathy heart disease hemolytic-uremic syndrome uveitis membranous glomerulonephritis adult acute respiratory distress syndrome nephrotic syndrome glomerulonephritis kidney disease thrombocytopenia pancreatitis Stevens-Johnson syndrome allergic disease angioedema hyperthyroxinemia, familial dysalbuminemic myopathy heart disease hemolytic-uremic syndrome uveitis membranous glomerulonephritis adult acute respiratory distress syndrome nephrotic syndrome glomerulonephritis kidney disease HIV infectious disease echinococcosis hypertensive disorder interstitial nephritis Pain diabetic peripheral angiopathy melancholia urticaria congenital analbuminemia nephrosis serum sickness keloid hepatitis brain disease membranoproliferative glomerulonephritis cardiovascular disease cerebrovascular disorder endogenous depression anuria nephritis aseptic meningitis congestive heart failure azoospermia brain ischemia acute liver failure poisoning epilepsy chronic kidney disease proteinuria cirrhosis of liver asthma respiratory failure influenza coronary artery disease neurodegenerative disease autoimmune disease dense deposit disease non-alcoholic fatty liver disease bone marrow disease hepatitis C virus infection toxic epidermal necrolysis lymphatic system disease pancreatic intraductal papillary-mucinous neoplasm breast disease type IV hypersensitivity disease perennial allergic rhinitis cancer peritonitis Ehlers-Danlos syndrome, arthrochalasis type primary biliary cholangitis arthritic joint disease protein-energy malnutrition chronic obstructive pulmonary disease psoriasis inborn carbohydrate metabolic disorder gastric neoplasm atherosclerosis respiratory system disease inherited lipid metabolism disorder COVID-19 neurotic disorder obesity disorder diabetic kidney disease brain injury liver disease diabetic retinopathy hereditary diffuse gastric adenocarcinoma breast cancer tuberculosis pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia peripheral neuropathy hyperglycemia pneumonia muscle tissue disease primary membranoproliferative glomerulonephritis cholestasis esophageal varices protein-losing enteropathy hypotensive disorder inflammatory bowel disease dementia heart failure hepatic encephalopathy skin disease depressive disorder hepatitis B virus infection stomach disease leukopenia thrombotic disease lung adenocarcinoma diarrheal disease pancreas disease hereditary hyperbilirubinemia breast carcinoma type 2 diabetes mellitus malignant pancreatic neoplasm acute kidney failure pancreatic intraductal papillary-mucinous carcinoma C1 inhibitor deficiency urinary tract infection drug-induced liver injury peripheral vascular disease hyperparathyroidism varicose disease metabolic acidosis anemia muscular disease prostate carcinoma hypoglycemia extrahepatic cholestasis idiopathic membranous glomerulonephritis nephrosclerosis gastric cancer

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.