Annotations: 4H6Y

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	PF00169	e4h6yB2	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: PF00169	ECOD (1.6)
B	PF00621	e4h6yB1	A: alpha bundles	X: DH domain-like	H: DBL homology domain (DH-domain) (From Topology)	T: DBL homology domain (DH-domain)	F: PF00621	ECOD (1.6)
A	PF00169	e4h6yA2	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: PF00169	ECOD (1.6)
A	PF00621	e4h6yA1	A: alpha bundles	X: DH domain-like	H: DBL homology domain (DH-domain) (From Topology)	T: DBL homology domain (DH-domain)	F: PF00621	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00169	PH domain (PH)	PH domain	PH stands for pleckstrin homology.	Domain
A, B	PF00621	RhoGEF domain (RhoGEF)	RhoGEF domain	Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that Pfam:PF00169 domains invariably occur C-terminal to RhoGEF/DH domains.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	FERM, RhoGEF and pleckstrin domain-containing protein 1	small GTPase binding protein binding binding enzyme binding GTPase binding cytoskeletal protein binding GTPase regulator activity enzyme regulator activity guanyl-nucleotide exchange factor activity nucleoside-triphosphatase regulator activity molecular function regulator activity	protein localization regulation of localization cellular localization regulation of cellular process regulation of protein localization positive regulation of biological process cellular component organization localization neuromuscular junction development receptor clustering cellular macromolecule localization synapse organization cellular component organization or biogenesis regulation of skeletal muscle acetylcholine-gated channel clustering protein localization regulation of localization cellular localization regulation of cellular process regulation of protein localization positive regulation of biological process cellular component organization localization neuromuscular junction development receptor clustering cellular macromolecule localization synapse organization cellular component organization or biogenesis regulation of skeletal muscle acetylcholine-gated channel clustering regulation of receptor clustering postsynaptic membrane organization regulation of protein localization to membrane positive regulation of cellular process membrane organization regulation of biological process postsynapse organization positive regulation of receptor clustering skeletal muscle acetylcholine-gated channel clustering biological regulation positive regulation of protein localization to membrane localization within membrane protein localization to membrane positive regulation of skeletal muscle acetylcholine-gated channel clustering cell junction organization regulation of cellular localization macromolecule localization positive regulation of protein localization cellular process actin cytoskeleton organization postsynaptic cytoskeleton organization organelle organization postsynaptic actin cytoskeleton organization actin filament-based process cytoskeleton organization multicellular organismal process regulation of cellular component organization regulation of presynapse assembly cellular component biogenesis multicellular organism development regulation of presynapse organization cellular component assembly cell junction assembly anatomical structure development regulation of synapse structure or activity regulation of biological quality regulation of synapse assembly system development developmental process presynapse organization nervous system development regulation of cellular component biogenesis regulation of cell junction assembly regulation of synapse organization synapse assembly presynapse assembly cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis neurogenesis cell projection morphogenesis neuron differentiation neuron projection morphogenesis dendrite development cell differentiation plasma membrane bounded cell projection organization dendrite morphogenesis cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron development cellular response to stimulus small GTPase-mediated signal transduction response to stimulus signaling Rac protein signal transduction intracellular signal transduction cell communication intracellular signaling cassette signal transduction trans-synaptic signaling trans-synaptic signaling by trans-synaptic complex retrograde trans-synaptic signaling cell-cell signaling retrograde trans-synaptic signaling by trans-synaptic protein complex synaptic signaling cell surface receptor signaling pathway enzyme-linked receptor protein signaling pathway	extrinsic component of plasma membrane synapse membrane plasma membrane cellular anatomical entity synaptic membrane cell periphery extrinsic component of synaptic membrane postsynapse postsynaptic membrane cell junction plasma membrane region extrinsic component of membrane extrinsic component of postsynaptic membrane extrinsic component of plasma membrane synapse membrane plasma membrane cellular anatomical entity synaptic membrane cell periphery extrinsic component of synaptic membrane postsynapse postsynaptic membrane cell junction plasma membrane region extrinsic component of membrane extrinsic component of postsynaptic membrane intracellular anatomical structure cytoplasm cytosol somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection glutamatergic synapse intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle non-membrane-bounded organelle neuron spine dendritic spine cytoplasmic side of plasma membrane cytoplasmic side of membrane side of membrane actin-based cell projection filopodium

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR000299	FERM domain	Domain
A, B	IPR001849	Pleckstrin homology domain	Domain
A, B	IPR014352	FERM/acyl-CoA-binding protein superfamily	Homologous Superfamily
A, B	IPR000219	Dbl homology (DH) domain	Domain
A, B	IPR019748	FERM central domain	Domain
A, B	IPR018980	FERM, C-terminal PH-like domain	Domain
A, B	IPR000798	Ezrin/radixin/moesin-like	Family
A, B	IPR041788	FARP1/FARP2/FRMD7, FERM domain C-lobe	Domain
A, B	IPR011993	PH-like domain superfamily	Homologous Superfamily
A, B	IPR014847	FERM adjacent	Domain
A, B	IPR019749	Band 4.1 domain	Domain
A, B	IPR035963	FERM superfamily, second domain	Homologous Superfamily
A, B	IPR019747	FERM conserved site	Conserved Site
A, B	IPR035899	Dbl homology (DH) domain superfamily	Homologous Superfamily
A, B	IPR018979	FERM, N-terminal	Domain
A, B	IPR029071	Ubiquitin-like domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q9Y4F1	ovarian cancer pilocytic astrocytoma psoriasis substance dependence atypical teratoid rhabdoid tumor Substance-Related Disorders esophageal adenocarcinoma heart disease large cell medulloblastoma pancreatic intraductal papillary-mucinous carcinoma substance abuse gastroesophageal reflux disease interstitial cystitis malignant ependymoma malignant pancreatic neoplasm ovarian cancer pilocytic astrocytoma psoriasis substance dependence atypical teratoid rhabdoid tumor Substance-Related Disorders esophageal adenocarcinoma heart disease large cell medulloblastoma pancreatic intraductal papillary-mucinous carcinoma substance abuse gastroesophageal reflux disease interstitial cystitis malignant ependymoma malignant pancreatic neoplasm osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia primitive neuroectodermal tumor substance-related disorder drug dependence endogenous depression glioblastoma invasive ductal breast carcinoma malignant glioma oligodendroglioma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.