Annotations: 4GXL

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Gal-bind_lectin	e4gxlA1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: Gal-bind_lectin	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00337	Galactoside-binding lectin (Gal-bind_lectin)	Galactoside-binding lectin	This family contains galactoside binding lectins. The family also includes enzymes such as human eosinophil lysophospholipase (Swiss:Q05315, EC:3.1.1.5).	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Galectin-8	binding carbohydrate binding cell adhesion molecule binding protein-containing complex binding protein binding integrin binding signaling receptor binding	developmental process multicellular organismal process endothelial cell migration vasculature development circulatory system development epithelium migration multicellular organism development anatomical structure morphogenesis tissue migration lymphatic endothelial cell migration ameboidal-type cell migration anatomical structure development epithelial cell migration cell migration developmental process multicellular organismal process endothelial cell migration vasculature development circulatory system development epithelium migration multicellular organism development anatomical structure morphogenesis tissue migration lymphatic endothelial cell migration ameboidal-type cell migration anatomical structure development epithelial cell migration cell migration cellular process cell motility lymph vessel morphogenesis lymph vessel development system development biological process involved in interspecies interaction between organisms catabolic process response to stimulus response to other organism defense response macroautophagy cellular metabolic process autophagy xenophagy response to external stimulus response to biotic stimulus cellular catabolic process defense response to other organism response to stress metabolic process response to external biotic stimulus process utilizing autophagic mechanism cellular response to virus response to virus	membrane-bounded organelle intracellular organelle intracellular anatomical structure cytoplasmic vesicle organelle intracellular vesicle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle vesicle membrane cytosol extracellular region extracellular space
B	Peptide from Calcium-binding and coiled-coil domain-containing protein 2	identical protein binding protein binding binding protein homodimerization activity protein dimerization activity cation binding ion binding metal ion binding small molecule binding	response to organic substance biological process involved in interspecies interaction between organisms response to stimulus immune response response to other organism defense response response to type II interferon response to cytokine defense response to symbiont response to external stimulus response to biotic stimulus response to chemical immune system process defense response to other organism response to stress response to organic substance biological process involved in interspecies interaction between organisms response to stimulus immune response response to other organism defense response response to type II interferon response to cytokine defense response to symbiont response to external stimulus response to biotic stimulus response to chemical immune system process defense response to other organism response to stress innate immune response response to external biotic stimulus viral process positive regulation of organelle organization catabolic process regulation of cellular process regulation of cellular component organization positive regulation of cellular component organization regulation of autophagosome maturation macroautophagy autophagy positive regulation of biological process protein-containing complex disassembly positive regulation of cellular metabolic process regulation of autophagy regulation of protein-containing complex disassembly cellular catabolic process cellular component organization positive regulation of metabolic process autophagosome maturation cellular component organization or biogenesis positive regulation of macroautophagy process utilizing autophagic mechanism positive regulation of protein-containing complex disassembly positive regulation of cellular process cellular component disassembly positive regulation of autophagy regulation of biological process protein-containing complex organization cellular metabolic process biological regulation regulation of cellular metabolic process regulation of catabolic process positive regulation of autophagosome maturation regulation of organelle organization positive regulation of catabolic process organelle organization regulation of macroautophagy regulation of cellular catabolic process positive regulation of cellular catabolic process cellular process metabolic process regulation of metabolic process xenophagy	membrane-bounded organelle intracellular organelle intracellular anatomical structure cytoplasmic vesicle organelle intracellular vesicle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle vesicle vacuole autophagosome vacuolar membrane autophagosome membrane membrane-bounded organelle intracellular organelle intracellular anatomical structure cytoplasmic vesicle organelle intracellular vesicle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle vesicle vacuole autophagosome vacuolar membrane autophagosome membrane membrane bounding membrane of organelle organelle membrane cytoskeleton intracellular non-membrane-bounded organelle non-membrane-bounded organelle cytosol perinuclear region of cytoplasm nucleus membrane-enclosed lumen intracellular organelle lumen nuclear body nucleoplasm organelle lumen PML body nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR044156	Galectin-like	Family
A	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily	Homologous Superfamily
A	IPR001079	Galectin, carbohydrate recognition domain	Domain
B	IPR041611	SKICH domain	Domain
B	IPR041641	CALCOCO1/2, zinc finger UBZ1-type	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: O00214	Pick disease psoriasis astrocytic tumor breast carcinoma Hashimoto thyroiditis juvenile dermatomyositis lung cancer medulloblastoma osteosarcoma pituitary cancer rheumatoid arthritis atypical teratoid rhabdoid tumor cystic fibrosis hypothyroidism large cell medulloblastoma Pick disease psoriasis astrocytic tumor breast carcinoma Hashimoto thyroiditis juvenile dermatomyositis lung cancer medulloblastoma osteosarcoma pituitary cancer rheumatoid arthritis atypical teratoid rhabdoid tumor cystic fibrosis hypothyroidism large cell medulloblastoma malignant ependymoma non-small cell lung carcinoma ovarian cancer primitive neuroectodermal tumor tuberculosis breast cancer ductal breast carcinoma in situ invasive ductal breast carcinoma lung adenocarcinoma malignant glioma oligodendroglioma
B	Pharos: Q13137	colorectal cancer breast cancer Colorectal Neoplasms lung cancer plasma cell myeloma heart disease malignant glioma colorectal carcinoma large cell medulloblastoma ovarian cancer

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.