4GGD

Structural analysis of human Cdc20 supports multisite degron recognition by APC/C.

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	WD40 repeat-like	8106388	3001694	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	WD40 repeat-like	8106388	3001694	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	ANAPC4_WD40_6	e4ggdA1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_6	ECOD (1.6)
B	ANAPC4_WD40_6	e4ggdB1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_6	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
B	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF12894	Anaphase-promoting complex subunit 4 WD40 domain (ANAPC4_WD40)	Anaphase-promoting complex subunit 4 WD40 domain	-	Repeat
A, B	PF00400	WD domain, G-beta repeat (WD40)	WD domain, G-beta repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Cell division cycle protein 20 homolog	enzyme regulator activity ubiquitin ligase activator activity enzyme activator activity ubiquitin-protein transferase regulator activity molecular function activator activity molecular function regulator activity ubiquitin-protein transferase activator activity protein-containing complex binding anaphase-promoting complex binding binding	positive regulation of proteasomal protein catabolic process catabolic process regulation of anaphase-promoting complex-dependent catabolic process proteolysis involved in protein catabolic process positive regulation of protein metabolic process positive regulation of biological process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process regulation of ubiquitin-dependent protein catabolic process regulation of primary metabolic process positive regulation of metabolic process organic substance metabolic process regulation of proteolysis involved in protein catabolic process regulation of proteolysis positive regulation of ubiquitin-dependent protein catabolic process positive regulation of proteasomal protein catabolic process catabolic process regulation of anaphase-promoting complex-dependent catabolic process proteolysis involved in protein catabolic process positive regulation of protein metabolic process positive regulation of biological process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process regulation of ubiquitin-dependent protein catabolic process regulation of primary metabolic process positive regulation of metabolic process organic substance metabolic process regulation of proteolysis involved in protein catabolic process regulation of proteolysis positive regulation of ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process proteolysis positive regulation of macromolecule metabolic process protein metabolic process organonitrogen compound catabolic process regulation of biological process organonitrogen compound metabolic process regulation of protein metabolic process biological regulation primary metabolic process proteasomal protein catabolic process protein catabolic process regulation of macromolecule metabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of proteolysis involved in protein catabolic process positive regulation of catabolic process regulation of proteasomal ubiquitin-dependent protein catabolic process modification-dependent protein catabolic process regulation of proteasomal protein catabolic process positive regulation of proteolysis positive regulation of anaphase-promoting complex-dependent catabolic process anaphase-promoting complex-dependent catabolic process ubiquitin-dependent protein catabolic process metabolic process positive regulation of proteasomal ubiquitin-dependent protein catabolic process macromolecule metabolic process organic substance catabolic process regulation of metabolic process regulation of protein catabolic process developmental process cellular developmental process cell differentiation cellular process multicellular organismal process regulation of cellular component organization regulation of cellular process positive regulation of cellular component organization regulation of developmental process cellular component organization positive regulation of developmental process multicellular organism development anatomical structure development regulation of synapse structure or activity synapse organization cellular component organization or biogenesis regulation of biological quality positive regulation of cellular process system development nervous system development developmental maturation synapse maturation regulation of synapse organization regulation of synapse maturation cell junction organization positive regulation of synapse maturation regulation of mitotic cell cycle cell cycle regulation of cell cycle mitotic cell cycle positive regulation of organelle organization regulation of cell cycle phase transition regulation of mitotic nuclear division positive regulation of mitotic nuclear division positive regulation of mitotic metaphase/anaphase transition positive regulation of mitotic cell cycle phase transition mitotic sister chromatid separation chromosome segregation regulation of cell cycle process positive regulation of nuclear division sister chromatid segregation regulation of chromosome organization regulation of organelle organization regulation of mitotic cell cycle phase transition mitotic cell cycle process regulation of chromosome separation regulation of chromosome segregation regulation of metaphase/anaphase transition of cell cycle regulation of mitotic sister chromatid separation cell cycle phase transition regulation of mitotic metaphase/anaphase transition positive regulation of metaphase/anaphase transition of cell cycle mitotic sister chromatid segregation positive regulation of cell cycle process positive regulation of mitotic cell cycle cell cycle process mitotic nuclear division organelle fission chromosome organization positive regulation of cell cycle organelle organization nuclear division chromosome separation regulation of sister chromatid segregation positive regulation of cell cycle phase transition positive regulation of mitotic sister chromatid separation regulation of nuclear division nuclear chromosome segregation metaphase/anaphase transition of mitotic cell cycle positive regulation of chromosome separation metaphase/anaphase transition of cell cycle mitotic cell cycle phase transition cell division cellular response to stimulus response to stimulus negative regulation of biological process spindle checkpoint signaling negative regulation of cell cycle intracellular signal transduction negative regulation of mitotic cell cycle cell communication negative regulation of mitotic sister chromatid segregation negative regulation of chromosome organization negative regulation of cell cycle phase transition mitotic spindle checkpoint signaling signal transduction negative regulation of sister chromatid segregation mitotic spindle assembly checkpoint signaling negative regulation of cellular component organization regulation of mitotic sister chromatid segregation negative regulation of mitotic nuclear division signaling spindle assembly checkpoint signaling negative regulation of cellular process negative regulation of mitotic metaphase/anaphase transition negative regulation of chromosome separation negative regulation of mitotic cell cycle phase transition negative regulation of cell cycle process cell cycle checkpoint signaling mitotic cell cycle checkpoint signaling negative regulation of chromosome segregation negative regulation of organelle organization negative regulation of nuclear division negative regulation of mitotic sister chromatid separation negative regulation of metaphase/anaphase transition of cell cycle regulation of synaptic plasticity trans-synaptic signaling regulation of signaling modulation of chemical synaptic transmission cell-cell signaling chemical synaptic transmission positive regulation of synaptic plasticity synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of cell communication protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal regulation of meiotic cell cycle sexual reproduction regulation of reproductive process reproductive process meiotic cell cycle regulation of protein modification process regulation of catalytic activity regulation of protein ubiquitination regulation of transferase activity positive regulation of post-translational protein modification regulation of ubiquitin protein ligase activity positive regulation of molecular function positive regulation of ubiquitin protein ligase activity positive regulation of protein modification process regulation of ubiquitin-protein transferase activity regulation of protein modification by small protein conjugation or removal positive regulation of protein modification by small protein conjugation or removal positive regulation of protein ubiquitination positive regulation of transferase activity regulation of post-translational protein modification positive regulation of catalytic activity positive regulation of ubiquitin-protein transferase activity regulation of molecular function meiotic cell cycle process metaphase/anaphase transition of meiotic cell cycle meiotic cell cycle phase transition meiosis I cell cycle process metaphase/anaphase transition of meiosis I mitotic sister chromatid cohesion sister chromatid cohesion non-membrane-bounded organelle assembly microtubule cytoskeleton organization cellular component biogenesis cellular component assembly microtubule cytoskeleton organization involved in mitosis spindle organization organelle assembly spindle assembly mitotic spindle organization mitotic spindle assembly microtubule-based process cytoskeleton organization meiotic nuclear division regulation of meiotic nuclear division	intracellular organelle intracellular anatomical structure cytoskeleton spindle organelle intracellular non-membrane-bounded organelle spindle pole cellular anatomical entity microtubule cytoskeleton non-membrane-bounded organelle centrosome microtubule organizing center cytoplasm cytosol intracellular organelle intracellular anatomical structure cytoskeleton spindle organelle intracellular non-membrane-bounded organelle spindle pole cellular anatomical entity microtubule cytoskeleton non-membrane-bounded organelle centrosome microtubule organizing center cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen chromosome chromosomal region kinetochore chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome protein-containing complex ubiquitin ligase complex catalytic complex nuclear protein-containing complex transferase complex anaphase-promoting complex cullin-RING ubiquitin ligase complex nuclear ubiquitin ligase complex intracellular protein-containing complex mitotic checkpoint complex
C, D	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups protein serine/threonine kinase activity protein serine kinase activity	chromosome organization sister chromatid cohesion meiotic sister chromatid cohesion, centromeric cellular component organization centromeric sister chromatid cohesion organelle organization cellular process cellular component organization or biogenesis cell cycle meiotic sister chromatid cohesion cell cycle process regulation of chromosome segregation regulation of cellular process regulation of cellular component organization chromosome organization sister chromatid cohesion meiotic sister chromatid cohesion, centromeric cellular component organization centromeric sister chromatid cohesion organelle organization cellular process cellular component organization or biogenesis cell cycle meiotic sister chromatid cohesion cell cycle process regulation of chromosome segregation regulation of cellular process regulation of cellular component organization cell cycle phase transition mitotic cell cycle regulation of cell cycle chromosome segregation regulation of biological process regulation of cell cycle process biological regulation sister chromatid segregation regulation of chromosome organization regulation of organelle organization mitotic cell cycle process regulation of sister chromatid segregation nuclear chromosome segregation metaphase/anaphase transition of mitotic cell cycle metaphase/anaphase transition of cell cycle mitotic cell cycle phase transition cell division protein localization localization cellular localization protein localization to chromosome, centromeric region protein localization to chromosome protein localization to organelle cellular macromolecule localization macromolecule localization phosphorylation cellular metabolic process phosphate-containing compound metabolic process metabolic process phosphorus metabolic process cellular response to stimulus regulation of cell cycle phase transition response to stimulus negative regulation of biological process spindle checkpoint signaling negative regulation of cell cycle regulation of mitotic nuclear division intracellular signal transduction negative regulation of mitotic cell cycle cell communication negative regulation of mitotic sister chromatid segregation negative regulation of chromosome organization negative regulation of cell cycle phase transition mitotic spindle checkpoint signaling signal transduction mitotic sister chromatid separation negative regulation of sister chromatid segregation mitotic spindle assembly checkpoint signaling negative regulation of cellular component organization regulation of mitotic cell cycle phase transition regulation of mitotic sister chromatid segregation regulation of chromosome separation negative regulation of mitotic nuclear division regulation of mitotic sister chromatid separation regulation of metaphase/anaphase transition of cell cycle signaling spindle assembly checkpoint signaling regulation of mitotic metaphase/anaphase transition regulation of mitotic cell cycle negative regulation of cellular process mitotic sister chromatid segregation negative regulation of mitotic metaphase/anaphase transition negative regulation of chromosome separation mitotic nuclear division negative regulation of mitotic cell cycle phase transition organelle fission negative regulation of cell cycle process cell cycle checkpoint signaling mitotic cell cycle checkpoint signaling nuclear division negative regulation of chromosome segregation chromosome separation negative regulation of organelle organization negative regulation of nuclear division negative regulation of mitotic sister chromatid separation regulation of nuclear division negative regulation of metaphase/anaphase transition of cell cycle apoptotic process cell death programmed cell death	intracellular anatomical structure chromosome cellular anatomical entity chromosomal region kinetochore intracellular organelle organelle intracellular non-membrane-bounded organelle chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome non-membrane-bounded organelle centrosome intracellular anatomical structure chromosome cellular anatomical entity chromosomal region kinetochore intracellular organelle organelle intracellular non-membrane-bounded organelle chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome non-membrane-bounded organelle centrosome microtubule organizing center cytoskeleton microtubule cytoskeleton membrane-bounded organelle protein-containing complex ubiquitin ligase complex catalytic complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle transferase complex anaphase-promoting complex cullin-RING ubiquitin ligase complex nuclear ubiquitin ligase complex intracellular protein-containing complex cytoplasm cytosol perinuclear region of cytoplasm spindle mitotic checkpoint complex outer kinetochore

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
A, B	IPR024977	Anaphase-promoting complex subunit 4-like, WD40 domain	Domain
A, B	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
A, B	IPR001680	WD40 repeat	Repeat
A, B	IPR033010	WD repeat Cdc20/Fizzy	Family
C, D	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
C, D	IPR015661	Mitotic spindle checkpoint protein Bub1/Mad3	Family
C, D	IPR013212	Mad3/Bub1 homology region 1	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q12834	malignant glioma medulloblastoma ovarian cancer primitive neuroectodermal tumor acute pancreatitis atypical teratoid rhabdoid tumor ductal breast carcinoma in situ glioblastoma IgA glomerulonephritis large cell medulloblastoma malignant colon neoplasm malignant mesothelioma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma psoriasis malignant glioma medulloblastoma ovarian cancer primitive neuroectodermal tumor acute pancreatitis atypical teratoid rhabdoid tumor ductal breast carcinoma in situ glioblastoma IgA glomerulonephritis large cell medulloblastoma malignant colon neoplasm malignant mesothelioma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma psoriasis adrenal cortex carcinoma breast cancer endometriosis hepatocellular carcinoma interstitial cystitis lung adenocarcinoma malignant ependymoma malignant pancreatic neoplasm osteosarcoma pancreatic intraductal papillary-mucinous neoplasm atopic eczema breast carcinoma esophageal adenocarcinoma hypertensive disorder invasive ductal breast carcinoma lung cancer
C, D	Pharos: O60566	premature chromatid separation trait esophageal squamous cell carcinoma mosaic variegated aneuploidy syndrome colorectal cancer embryonal rhabdomyosarcoma microcephaly mosaic variegated aneuploidy syndrome 1 germ cell tumor embryonal neoplasm pancreatic intraductal papillary-mucinous carcinoma Germ Cell Cancer rhabdomyosarcoma hydrocephalus interstitial cystitis adrenal cortex carcinoma premature chromatid separation trait esophageal squamous cell carcinoma mosaic variegated aneuploidy syndrome colorectal cancer embryonal rhabdomyosarcoma microcephaly mosaic variegated aneuploidy syndrome 1 germ cell tumor embryonal neoplasm pancreatic intraductal papillary-mucinous carcinoma Germ Cell Cancer rhabdomyosarcoma hydrocephalus interstitial cystitis adrenal cortex carcinoma lung adenocarcinoma B-cell chronic lymphocytic leukemia malignant glioma cancer medulloblastoma cataract nasopharyngeal carcinoma cystic fibrosis non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm genetic endocrine growth disease primitive neuroectodermal tumor heart disease IgA glomerulonephritis invasive ductal breast carcinoma atopic eczema lung cancer breast cancer malignant mesothelioma colorectal carcinoma ductal breast carcinoma in situ ovarian cancer endometriosis pituitary cancer glioblastoma psoriasis hepatocellular carcinoma sinusitis intellectual disability large cell medulloblastoma atypical teratoid rhabdoid tumor malignant ependymoma breast carcinoma malignant pancreatic neoplasm microlissencephaly chronic kidney disease myocardial infarction

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.