4GBY

The structure of the MFS (major facilitator superfamily) proton:xylose symporter XylE bound to D-xylose

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	MFS_1	e4gbyA5	A: alpha complex topology	X: Major facilitator superfamily (MFS) general substrate transporter (From Topology)	H: Major facilitator superfamily (MFS) general substrate transporter (From Topology)	T: Major facilitator superfamily (MFS) general substrate transporter	F: MFS_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.1250.20	Mainly Alpha	Up-down Bundle	Growth Hormone	Chain: A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00083	Sugar (and other) transporter (Sugar_tr)	Sugar (and other) transporter	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	D-xylose-proton symporter	monoatomic cation transmembrane transporter activity D-xylose transmembrane transporter activity monosaccharide transmembrane transporter activity sugar transmembrane transporter activity proton transmembrane transporter activity solute:monoatomic cation symporter activity pentose transmembrane transporter activity secondary active transmembrane transporter activity carbohydrate:monoatomic cation symporter activity active monoatomic ion transmembrane transporter activity D-xylose:proton symporter activity carbohydrate:proton symporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity solute:proton symporter activity monoatomic cation transmembrane transporter activity D-xylose transmembrane transporter activity monosaccharide transmembrane transporter activity sugar transmembrane transporter activity proton transmembrane transporter activity solute:monoatomic cation symporter activity pentose transmembrane transporter activity secondary active transmembrane transporter activity carbohydrate:monoatomic cation symporter activity active monoatomic ion transmembrane transporter activity D-xylose:proton symporter activity carbohydrate:proton symporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity solute:proton symporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity carbohydrate transmembrane transporter activity transmembrane transporter activity symporter activity	D-xylose transmembrane transport pentose transmembrane transport transport organic substance transport carbohydrate transport establishment of localization transmembrane transport localization cellular process monosaccharide transmembrane transport carbohydrate transmembrane transport	cell periphery plasma membrane membrane cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR003663	Sugar/inositol transporter	Family
A	IPR005828	Major facilitator, sugar transporter-like	Family
A	IPR036259	MFS transporter superfamily	Homologous Superfamily
A	IPR005829	Sugar transporter, conserved site	Conserved Site
A	IPR047984	D-xylose-proton symporter-like	Family
A	IPR020846	Major facilitator superfamily domain	Domain

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Major Facilitator Superfamily (MFS) Transporters	XylE proton:xylose symporter with bound D-xylose

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.