Annotations: 4FZF

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Protein kinase-like (PK-like)	8062549	3000066	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	ARM repeat-like	8041962	3000116	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Pkinase_Tyr	e4fzfB1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Pkinase_Tyr	ECOD (1.6)
A	Mo25	e4fzfA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Mo25	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.30.200.20	Alpha Beta	2-Layer Sandwich	Phosphorylase Kinase	domain 1	CATH (4.3.0)
B	1.10.510.10	Mainly Alpha	Orthogonal Bundle	Transferase(Phosphotransferase)	domain 1	CATH (4.3.0)
A	1.25.10.10	Mainly Alpha	Alpha Horseshoe	Leucine-rich Repeat Variant	Leucine-rich Repeat Variant	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B	PF00069	Protein kinase domain (Pkinase)	Protein kinase domain	-	Domain
A	PF08569	Mo25-like (Mo25)	Mo25-like	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B	Serine/threonine-protein kinase MST4	catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity protein serine kinase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity protein serine kinase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding identical protein binding protein binding protein homodimerization activity protein dimerization activity protein serine/threonine kinase activity	cellular process apoptotic process cell death programmed cell death regulation of biological process regulation of cellular process regulation of apoptotic process biological regulation regulation of programmed cell death protein phosphorylation organonitrogen compound metabolic process protein autophosphorylation phosphorylation cellular metabolic process cellular process apoptotic process cell death programmed cell death regulation of biological process regulation of cellular process regulation of apoptotic process biological regulation regulation of programmed cell death protein phosphorylation organonitrogen compound metabolic process protein autophosphorylation phosphorylation cellular metabolic process primary metabolic process organic substance metabolic process macromolecule modification phosphate-containing compound metabolic process metabolic process protein metabolic process macromolecule metabolic process protein modification process phosphorus metabolic process plasma membrane bounded cell projection organization cell projection organization plasma membrane bounded cell projection assembly microvillus organization cellular component organization cellular component biogenesis cellular component assembly microvillus assembly cellular component organization or biogenesis cell projection assembly cellular response to stimulus cellular response to nutrient levels response to nutrient levels response to stimulus cellular response to stress response to stress response to starvation cellular response to starvation signaling intracellular signal transduction cell communication stress-activated protein kinase signaling cascade signal transduction negative regulation of locomotion regulation of cell motility negative regulation of biological process regulation of locomotion negative regulation of cellular process regulation of cell migration negative regulation of cell motility cell migration cell motility negative regulation of cell migration locomotion response to hydrogen peroxide response to oxidative stress response to chemical response to oxygen-containing compound response to reactive oxygen species response to inorganic substance	membrane cellular anatomical entity cell periphery apical part of cell plasma membrane plasma membrane region apical plasma membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space membrane cellular anatomical entity cell periphery apical part of cell plasma membrane plasma membrane region apical plasma membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle Golgi-associated vesicle cytoplasm cytosol vesicle membrane organelle membrane Golgi apparatus endomembrane system perinuclear region of cytoplasm
A	Calcium-binding protein 39	protein binding binding kinase binding enzyme binding enzyme regulator activity kinase activator activity enzyme activator activity molecular function activator activity molecular function regulator activity protein kinase activator activity protein kinase regulator activity kinase regulator activity protein serine/threonine kinase activator activity	regulation of localization regulation of potassium ion transport regulation of cellular process negative regulation of ion transmembrane transporter activity negative regulation of potassium ion transmembrane transporter activity transport monoatomic ion transmembrane transport negative regulation of monoatomic ion transport negative regulation of biological process potassium ion transmembrane transport regulation of transmembrane transporter activity negative regulation of transport regulation of monoatomic ion transmembrane transport metal ion transport negative regulation of transmembrane transport regulation of localization regulation of potassium ion transport regulation of cellular process negative regulation of ion transmembrane transporter activity negative regulation of potassium ion transmembrane transporter activity transport monoatomic ion transmembrane transport negative regulation of monoatomic ion transport negative regulation of biological process potassium ion transmembrane transport regulation of transmembrane transporter activity negative regulation of transport regulation of monoatomic ion transmembrane transport metal ion transport negative regulation of transmembrane transport regulation of transporter activity monoatomic cation transmembrane transport localization negative regulation of monoatomic ion transmembrane transport negative regulation of cellular process monoatomic ion transport negative regulation of cation transmembrane transport monoatomic cation transport regulation of metal ion transport regulation of potassium ion transmembrane transporter activity negative regulation of potassium ion transport regulation of monoatomic ion transmembrane transporter activity regulation of biological process regulation of transport regulation of monoatomic ion transport biological regulation negative regulation of transporter activity negative regulation of molecular function inorganic ion transmembrane transport negative regulation of potassium ion transmembrane transport regulation of potassium ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport regulation of molecular function regulation of transmembrane transport potassium ion transport cellular process regulation of monoatomic cation transmembrane transport response to organic substance response to thyroid hormone response to stimulus response to hormone response to chemical response to endogenous stimulus positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of biological process regulation of peptidyl-threonine phosphorylation positive regulation of cellular metabolic process positive regulation of phosphate metabolic process regulation of primary metabolic process positive regulation of metabolic process positive regulation of protein modification process organic substance metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process peptidyl-amino acid modification positive regulation of macromolecule metabolic process protein metabolic process peptidyl-threonine modification positive regulation of protein phosphorylation phosphorus metabolic process protein modification process positive regulation of cellular process organonitrogen compound metabolic process protein phosphorylation positive regulation of phosphorus metabolic process positive regulation of peptidyl-threonine phosphorylation phosphorylation cellular metabolic process regulation of protein metabolic process regulation of cellular metabolic process primary metabolic process regulation of macromolecule metabolic process macromolecule modification regulation of phosphorus metabolic process metabolic process regulation of phosphorylation macromolecule metabolic process regulation of metabolic process peptidyl-threonine phosphorylation peptidyl-serine modification peptidyl-serine phosphorylation regulation of catalytic activity regulation of transferase activity positive regulation of protein serine/threonine kinase activity positive regulation of kinase activity regulation of kinase activity regulation of protein serine/threonine kinase activity positive regulation of molecular function positive regulation of protein kinase activity positive regulation of transferase activity positive regulation of catalytic activity regulation of protein kinase activity response to activity cellular response to stimulus signaling signal transduction intracellular signal transduction cell communication response to osmotic stress cellular hypotonic response cellular response to chemical stress cellular response to osmotic stress cellular response to environmental stimulus hypotonic response cellular response to chemical stimulus cellular response to stress response to stress response to abiotic stimulus cellular response to abiotic stimulus	intracellular anatomical structure cellular anatomical entity Z disc sarcomere intracellular organelle I band organelle intracellular non-membrane-bounded organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex intracellular anatomical structure cellular anatomical entity Z disc sarcomere intracellular organelle I band organelle intracellular non-membrane-bounded organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex non-membrane-bounded organelle extracellular region extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular space vesicle extracellular membrane-bounded organelle vesicle lumen intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen secretory granule lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen cytoplasmic vesicle organelle lumen secretory granule secretory vesicle protein kinase complex transferase complex, transferring phosphorus-containing groups protein-containing complex catalytic complex serine/threonine protein kinase complex transferase complex cytosol ficolin-1-rich granule ficolin-1-rich granule lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B	IPR017441	Protein kinase, ATP binding site	Binding Site
B	IPR046409	Programmed cell death protein 10, dimerisation domain superfamily	Homologous Superfamily
B	IPR000719	Protein kinase domain	Domain
B	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
B	IPR048288	Programmed cell death protein 10, dimerisation domain	Domain
B	IPR035056	MST4, kinase domain	Domain
A	IPR016024	Armadillo-type fold	Homologous Superfamily
A	IPR011989	Armadillo-like helical	Homologous Superfamily
A	IPR013878	Mo25-like	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B	Pharos: Q9P289	plasma cell myeloma adenoma gastric adenocarcinoma large cell medulloblastoma lymphoplasmacytic lymphoma malignant pancreatic neoplasm ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia cystic fibrosis HER2-positive carcinoma of breast lung cancer malignant ependymoma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma pituitary cancer plasma cell myeloma adenoma gastric adenocarcinoma large cell medulloblastoma lymphoplasmacytic lymphoma malignant pancreatic neoplasm ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia cystic fibrosis HER2-positive carcinoma of breast lung cancer malignant ependymoma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma pituitary cancer ductal breast carcinoma in situ invasive ductal breast carcinoma lung carcinoma malignant mesothelioma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm
A	Pharos: Q9Y376	atypical teratoid rhabdoid tumor large cell medulloblastoma osteosarcoma hereditary spastic paraplegia lymphoplasmacytic lymphoma ovarian cancer IgA glomerulonephritis medulloblastoma ulcerative colitis

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.